Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (22): 3551-3557.doi: 10.3969/j.issn.2095-4344.3158

Previous Articles     Next Articles

Designing of periosteum tissue engineering: combination of generality and individuality

Zhou Anqi1, Tang Yufei1, Wu Bingfeng1, Xiang Lin1, 2    

  1. 1State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China; 2Department of Oral Implantology of West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2020-05-06 Revised:2020-05-12 Accepted:2020-06-17 Online:2021-08-08 Published:2021-01-20
  • Contact: Xiang Lin, MD, Lecturer, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China; Department of Oral Implantology of West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
  • About author:Zhou Anqi, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81701007 (to XL); the Sichuan Science and Technology Program, No. 2018RZ0087 (to XL); the Fundamental Research Funds for the Central Universities, No. 2018SCUH0006 (to XL);  Research Funding for Talents Developing, West China Hospital of Stomatology Sichuan University, No. RCDWJS2020-6 (to XL); the Basic and Applied Basic Research Project of West China Hospital of Stomatology of Sichuan University, No. RD-02-201902 (to XL)

Abstract: BACKGROUND: Tissue engineered periosteum has broad application prospect in bone repair for its promising osteogenic potential. However, we are facing the dilemma of taking advantage of periosteum to develop an optimal strategy for bone regeneration.
OBJECTIVE: In this review, we summary the histological structure and osteogenic potential of periosteum as well as its application in tissue engineering from the point of view of generality and individuality, discuss some undefined issues of periosteum tissue engineering and explore perspective strategies for bone repair.
METHODS: We searched in PubMed, Embase, Web of Science, CNKI and Wanfang databases with the main keywords of “periosteal osteogenesis; periosteum tissue engineering; PDC; PEM; periosteal structure; scaffold of periosteal tissue engineering; vascularized periosteum” and 69 articles were included for the review.
RESULTS AND CONCLUSION: The designing of tissue engineered periosteum is based on the structure of natural periosteum. The components of natural periosteum are widely used in periosteum tissue engineering. However, limited researches on osteogenic potential of various components and their combinations hinder our understanding and how to design the optimal tissue engineered periosteum remains to be further clarified. Here, we propose a new strategy called “Generality and Individuality”, which customizes tissue engineered periosteum on the basis of commonality to meet the clinical needs of bone repair better. We believe it is of great significance to reach the practically sound combination of generality and individuality and achieve the optimal curative effect of bone repair in the future researches.

Key words: periosteum, heterogeneity, osteogenesis, tailoring, bone repair, bone defect, biomaterials, tissue engineering, review

CLC Number: