Self-made Fe3O4 versus gelatin sponge embolic agents in rabbit pulmonary microcirculation

doi:10.3969/j.issn.2095-4344.2013.12.001

Abstract

Abstract:

BACKGROUND: Studies have shown that small-particle embolic agents can easily perform embolization by micro-catheter, and the arterioles can be embolized well by 50-100 μm particles to reduce collateral circulation generation.
OBJECTIVE: To observe the pathological changes following embolizing rabbit pulmonary microcirculation with self-made embolic agents.
METHODS: Self-made Fe3O4 fine particles with a size of 50, 100, 150, 200, 250 μm and self-made gelatin sponge with a diameter of 500-1 000 μm were employed for interventional embolism of the pulmonary artery from New Zealand white rabbits. Then, the embolic effect was observed.
RESULTS AND CONCLUSION: Angiography and pathological results showed that 50, 150, 250 μm Fe₃O₄ fine particles and gelatin sponge particle could embolize to different-diameter microcirculatory blood vessels. Fe3O4 fine particles could result in the embolization of rabbit capillaries and precapillary arterioles until 1-4 weeks after interventional embolism, indicating that Fe3O4 fine particle had a long-time embolism effect. Fe₃O₄fine particles could also pass though the microtubule, and no ectopic embolization was visible. Gelatin sponge particles that were unable to pass through the microtubule could block the small arteries with a diameter of (1 300±348) μm. Gelatin sponge particles could be absorbed within 1-2 weeks after embolization. These findings suggest that Fe3O4 particles have good embolic effect that is persistent and complete, and it is difficult to vascular recanalization and establishment of collateral circulation after embolization. Gelatin sponge as an embolic agent is suitable for branches and small arteries rather than the microcirculation.

Key words: biomaterials, biomaterials and controlled drug release, self-made embolic agent, Fe₃O₄ fine particles, self-made gelatin sponge particles, rabbits, pulmonary microcirculatory vessel, embolization, intervention, permanent embolization effect, collateral circulation establishment, microcirculation embolism, provincial grants-supported paper, biomaterial photographs-containing paper

CLC Number:

R318

Yang Qing, Tong Yu-yun, Guo Li, Wang Jia-ping, Li Ying-chun, Jiang Hua. Self-made Fe₃O₄versus gelatin sponge embolic agents in rabbit pulmonary microcirculation[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(12): 2091-2099.

Figures/Tables 9

References

[1] Bilbao JI, Martínez-Cuesta A, Urtasun F. Complications of embolization. Semin Intervent Radiol. 2006;23(2):126-142.

[2] Walsh KP. Advanced embolization techniques. Pediatr Cardiol. 2005;26(3):275-288.

[3] Al-Shahi R, Warlow C. Arteriovenous malformations of the brain: ready to randomisel. J Neurol Neurosurg Psychiatry. 2005;76(10):1327-1329

[4] White RI Jr. Pulmonary arteriovenous malformations: how do I embolize? Tech Vasc Interv Radiol. 2007;10(4):283-290.

[5] Kjeldsen AD, Andersen PE, Oxhøj H, et al. Percutaneous transluminal embolization of pulmonary arteriovenous malformations. Ugeskr Laeger. 1998;160(10):1465-1469.

[6] Vaidya S, Kathleen R. An overview of embolic agents. Semin Intervent Radiol. 2008;25(3):204-215.

[7] Becker TA, Preul MC, Bichard WD, et al. Calcium alginate gel as a biocompatible material for endovascular arteriovenous malformation embolization: six-month results in an animal model. Neurosurgery. 2005;56:793-801.

[8] Becker TA, Preul MC, Bichard WD, et al. Preliminary investigation of calcium alginate gel as a biocompatible material for endovascular aneurysm embolization in vivo. Neurosurgery. 2007;60:1119-1128.

[9] Vanninen R L, Manninen I. Onyx, a new liquid embolic material for peripheral interventions: preliminary experience in aneurysm, pseudoaneurysm, and pulmonary arteriovenous malformation embolization. Cardiovasc Intervent Radiol. 2007; 30(2):196-200.

[10] Raffi L, Simonetti L, Cenni P, et al. Use of Glubran 2 acrylic glue in interventional neuroradiology. Neuroradiology. 2007; 49:829-836.

[11] Pollak JS, White RI. The use of cyanoacrylate adhesives in peripheral embolization. J Vasc Interv Radiol. 2001;12: 907-913.

[12] Osuga K, Mikami K, Higashihara H, et al. Principles and techniques of transcatheter embolotherapy for peripheral vascular lesions. Radiat Med. 2006;24(4):309-314.

[13] Spies J B, Cornell C, Worthington-Kirsch R, et al. Long-term outcome from uterine fibroid embolization with tris-acryl gelatin microspheres: results of a multicenter study. J Vasc Interv Radiol. 2007;18(2):203-207.

[14] Becker TA, Kipke DR, Brandon T. Calcium alginate gel: a biocompatible and mechanically stable polymer for endovascular embolization. J Biomed Mater Res. 2001; 54(1):76-86.

[15] López-Benítez R, Richter GM, Kauczor HU, et al. Analysis of nontarget embolization mechanisms during embolization and chemoembolization procedures. Cardiovasc Intervent Radiol. 2009;32(4):615-622.

[16] Hidaka K, Nakamura M, Osuga K, et al. Elastic characteristics of microspherical embolic agents used for vascular interventional radiology. 2010;3(7):497-503.

[17] Hidaka K, Moine L, Collin G, et al. Elasticity and viscoelasticity of embolization microspheres. J Mech Behav Biomed Mater. 2011;4(8):2161-2167.

[18] Yoon W. Embolic agents used for bronchial artery embolisation in massive haemoptysis. Expert Opin Pharmacother. 2004;5(2):361-367.

[19] Loffroy R, Guiu B, Cercueil JP, et al. Endovascular therapeutic embolisation: an overview of occluding agents and their effects on embolised tissues. Curr Vasc Pharmacol. 2009;7(2):250-263.

[20] Lewis AL, Adams C, Busby W etal.Comparative in vitro evaluation of microspherical embolisation agents. J Mater Sci Mater Med. 2006;17(12):1193-1204.

[21] Stampfl S, Bellemann N, Stampfl U, et al. Arterial distribution characteristics of Embozene particles and comparison with other spherical embolic agents in the porcine acute embolization model. J Vasc Interv Radiol. 2009;20(12): 1597-607.

[22] Stampfl S, Bellemann N, Stampfl U, et al. Inflammation and recanalization of four different spherical embolization agents in the porcine kidney model. J Vasc Interv Radiol. 2008;19(4): 577-586.

[23] Bilbao JI, de Luis E, García de Jalón JA, et al. Comparative study of four different spherical embolic particles in an animal model: a morphologic and histologic evaluation. J Vasc Interv Radiol. 2008;19(11):1625-1638.

[24] Abada HT, Golzarian J. Gelatine sponge particles: handling characteristics for endovascular use. Tech Vasc Interv Radiol. 2007;10(4):257-260.

[25] White RI Jr, Pollak JS, Wirth JA. Pulmonary arteriovenous malformations: diagnosis and transcatheter embolotherapy. J Vasc Interv Radiol. 1996;7(6):787-804.

[26] Gulati MS, Srinivasan A, Paul SB, et al. Uterine restoration following fibroid expulsion after uterine artery embolisation using gelfoam. J Postgrad Med. 2004;50(1):80.

[27] Katsumori T, Kasahara T, Akazawa K. Long-term outcomes of uterine artery embolization using gelatin sponge particles alone for symptomatic fibroids. AJR Am J Roentgenol. 2006; 186(3):848-854.

[28] The Ministry of Science and Technology of the People’s Republic of China. Guidance Suggestions for the Care and Use of Laboratory Animals. 2006-09-30.

Self-made Fe₃O₄versus gelatin sponge embolic agents in rabbit pulmonary microcirculation

PDF

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 9

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Huang Dengcheng, Wang Zhike, Cao Xuewei. Intravenous, topical tranexamic acid alone or their combination in total knee arthroplasty: a meta-analysis of randomized controlled trials [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(6): 948-956.
[2]	Li Li, Ma Li. Immobilization of lactase on magnetic chitosan microspheres and its effect on enzymatic properties [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(4): 576-581.
[3]	Zhou Anqi, Tang Yufei, Wu Bingfeng, Xiang Lin. Designing of periosteum tissue engineering: combination of generality and individuality [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(22): 3551-3557.
[4]	Lang Limin, He Sheng, Jiang Zengyu, Hu Yiyi, Zhang Zhixing, Liang Minqian. Application progress of conductive composite materials in the field of tissue engineering treatment of myocardial infarction [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(22): 3584-3590.
[5]	Xie Jian, Su Jiansheng. Advantages and characteristics of electrospun aligned nanofibers as scaffolds for tissue engineering [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(16): 2575-2581.
[6]	Ji Qi, Yu Zhengwen, Zhang Jian. Problems and trends of technique and clinical application of metallic biomaterials prepared by three-dimensional printing technology [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(16): 2597-2604.
[7]	Qian Nannan, Zhang Qian, Yang Rui, Ao Jun, Zhang Tao. Mesenchymal stem cells in the treatment of spinal cord injury: cell therapy and combination of new drugs and biomaterials [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(13): 2114-2120.
[8]	Jia Wei, Zhang Mandong, Chen Weiyi, Wang Chenyan, Guo Yuan. Effects of femoral prosthetic materials on artificial knee arthroplasty performance [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(10): 1477-1481.
[9]	Wang Qian, Li Lu, Shu Jingyuan, Dong Zhiheng, Jin Youshi, Wang Qingshan. Micro-morphology and phase of zirconia-based nano-hydroxyapatite functional gradient biomaterials [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(10): 1517-1521.
[10]	Li Xiao, Pan Jinbing, Ma Yun, Qian Haoyu, Zhang Quncheng, Wang Zheng. Silicone stent insertion for treating tracheobronchomalacia in adults [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(4): 549-554.
[11]	Xie Xiufeng, Zhang Yue, Qu Ze. Clinical outcomes of drug-eluting balloons and drug-eluting stents for the treatment of in-stent restenosis [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(4): 555-560.
[12]	Li Li, Ma Li, Li He. Preparation and characterization of magnetic chitosan microspheres [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(4): 577-582.
[13]	Tang Mengmeng, Chen Hechun, Xie Hongchen, Zhang Yu, Tan Xiaoshuang, Sun Yixuan, Huang Yina. Histocompatibility of poly(L-lactide-co-ε-caprolactone)/cross-linked polyvinylpyrrolidone ureteral stent grafted into the rat bladder [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(4): 583-588.
[14]	Chen Zegang, Ding Haili, Li Long, Wang Chun. Changes of bone metabolism after different intensity endurance exercises in growing rats [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(35): 5582-5588.
[15]	Guo Enhui, Xu Zitong, Liang Yize, Zhou Liang, Lu Zhaoxiang, You Liang, Xia Yujun. Properties of a novel photocrosslinked fish collagen peptide-hyaluronic acid hydrogel [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(28): 4518-4525.