Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (3): 445-451.doi: 10.12307/2023.876

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Application of bio-inks for 3D printing in tissue repair and regenerative medicine

Yang Jie1, Hu Haolei2,  Li Shuo1, Yue Wei2, Xu Tao3, Li Yi2   

  1. 1Xinxiang Medical University, Xinxiang 453003, Henan Province, China; 2Department of Otolaryngology Head and Neck Surgery, 988 Hospital of the Joint Service Support Force of Chinese PLA, Zhengzhou 450042, Henan Province, China; 3Biological Manufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
  • Received:2022-11-11 Accepted:2023-01-10 Online:2024-01-28 Published:2023-07-10
  • Contact: Li Yi, Chief physician, Professor, Master’s supervisor, Department of Otolaryngology Head and Neck Surgery, 988 Hospital of the Joint Service Support Force of Chinese PLA, Zhengzhou 450042, Henan Province, China
  • About author:Yang Jie, Master candidate, Xinxiang Medical University, Xinxiang 453003, Henan Province, China

Abstract: BACKGROUND: With the right bio-inks, 3D printing can be used to create replacements for human tissues and organs that work inside the body. In recent years, 3D printing technology has developed rapidly and has great application potential in regenerative medicine.
OBJECTIVE: To introduce the types of bio-inks for 3D printing, and review the classification, application, advantages and disadvantages of bio-inks, as well as the future vision.
METHODS: With “3D printing, biological ink, tissue engineering, hydrogel, synthetic material, cytoactive factor” as search terms, relevant articles published on PubMed and CNKI databases from 2000 to 2022 were searched by computer and finally 83 articles were included for review. 
RESULTS AND CONCLUSION: 3D bioprinting technology has developed rapidly over the past few decades and has received great attention in various fields, including tissue engineering and biomedicine. Compared with the limitations of traditional biological scaffold manufacturing methods in terms of function and structure, 3D printing can better simulate the complex structure of biological tissues and has appropriate mechanical, rheological and biological characteristics. Bio-ink is an essential part of 3D printing. Bioscaffolds produced by printing bio-ink prepared by biological materials have great scientific potential and clinical significance in tissue repair and regenerative medicine. The research of the materials itself is also getting more and more attention from experts. Bio-inks for 3D printing come in a variety of materials, from natural to synthetic, to aggregations of cells that do not require any additional biomaterials, and their usefulness in practical use varies. In the future, more and more bio-inks will be developed for tissue engineering. It is necessary to analyze the printability of bio-inks through sufficient experimental simulation and equipment testing to meet the actual medical needs.

Key words: bio-ink, 3D printing, biomaterial, tissue engineering, composite material, review

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