中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (19): 3588-3592.doi: 10.3969/j.issn.1673-8225.2012.19.033

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

脊髓神经干细胞Niche的研究进展**★

廖法学，张  辉，尹宗生   

  1. 安徽医科大学第一附属医院骨二科，安徽省合肥市 230022
  • 收稿日期:2012-02-02 修回日期:2012-03-10 出版日期:2012-05-06 发布日期:2012-05-06
  • 通讯作者: 尹宗生，博士，教授，博士生导师，安徽医科大学第一附属医院骨二科，安徽省合肥市 230022 yinzongsheng@sina.com.cn
  • 作者简介:廖法学★，男，安徽医科大学在读硕士，主要从事脊髓损伤治疗方面的研究。liaofaxue@126.com
  • 基金资助:

    国家自然科学基金项目(30973026)；安徽省自然科学基金项目(1104060625)。

Research progress in spinal cord neural stem cell Niche

Liao Fa-xue, Zhang Hui, Yin Zong-sheng   

  1. Second Department of Orthopedics, First Affiliated Hospital of Anhui Medical University, Hefei  230022, Anhui Province, China
  • Received:2012-02-02 Revised:2012-03-10 Online:2012-05-06 Published:2012-05-06
  • Contact: Yin Zong-sheng, M.D., Professor, Doctoral supervisor, Second Department of Orthopedics, First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China yinzongsheng@sina.com.cn
  • About author:Liao Fa-xue★, Studying for master’s degree, Second Department of Orthopedics, First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China liaofaxue@126.com
  • Supported by:

     the National Natural Science Foundation of China, No. 30973026*; the Natural Science Foundation of Anhui Province, No. 1104060625*

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摘要：

背景：脊髓损伤是临床上常见的骨科疾病，大量工作聚焦于神经干细胞治疗脊髓损伤的研究上，脊髓神经干细胞Niche对神经干细胞的作用成为了新的热点。
目的：综述脊髓神经干细胞Niche的相关研究进展。
方法：应用计算机检索PubMed 1980-01/2011-11期间的相关文章，检索词为“neural stem cells，niche/microenvironment，spinal cord”，并限定文章语言种类为English。同时计算机检索中国期刊全文数据库2003-01/2011-11 期间的相关文章，检索词为“神经干细胞，微环境，脊髓损伤”，并限定文章语言种类为中文。此外还手工查阅相关专著数部。
结果与结论：共检索到文献483篇，最终纳入31 篇。脊髓神经干细胞Niche为脊髓神经干细胞生存、自我更新以及分化提供了相对稳定的微环境，脊髓损伤后脊髓神经干细胞Niche的变化对脊髓神经干细胞的命运有着重要的影响。了解脊髓神经干细胞Niche中的神经干细胞、细胞组成、分子调节以及脊髓损伤后这一Niche中部分细胞的变化等的研究进展为应用神经干细胞治疗脊髓损伤提供了理论基础。
 

关键词: 神经干细胞, 微环境, 脊髓, 脊髓损伤, 综述文献

Abstract:

BACKGROUND: Spinal cord injury is a common orthopedic disease. A lot of work has been done to focus on neural stem cells for treating spinal cord injury. The effect of spinal cord neural stem cell Niche on neural stem cells has become a gradually increasing research area.
OBJECTIVE: To summarize the related research progress in spinal cord neural stem cell Niche.
METHODS: A computer-based online search of Pubmed (1980-01/2011-11) and CNKI (2003-01/2011-11) was performed for articles in English and Chinese respectively with the key words “neural stem cells, niche/microenvironment, spinal cord”. In addition, manual search was performed.
RESULTS AND CONCLUSION: A total of 483 articles were obtained, and finally 31 articles were included. The Niche provides a relatively stable microenvironment for survival, self-renewal and differentiation of spinal cord neural stem cells. After spinal cord injury, the change of Niche plays an important impact on the fate of spinal cord neural stem cells. Understanding the research progress of spinal cord neural stem cell Niche would provide a theoretical basis for treatment of spinal cord injury using neural stem cells.

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