中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (14): 2585-2588.doi: 10.3969/j.issn.1673-8225.2012.14.024

• 干细胞基础实验 basic experiments of stem cells • 上一篇    下一篇

人脐带间充质干细胞治疗失代偿期肝硬化的近期效果*★

张月凡1，李  楠2，翟俊山2，姜丽君2， 曹建宁3   

  1. 1解放军军医进修学院，北京市 100853；2解放军第309医院消化内科，北京市 100091；3深圳市北科生物科技有限公司，广东省深圳市  518057
  • 收稿日期:2011-10-09 修回日期:2011-11-18 出版日期:2012-04-01 发布日期:2012-04-01
  • 通讯作者: 李楠，主任医师，博士，博士生导师，解放军第309医院消化科，北京市 100091 linan957@sina.com
  • 作者简介:张月凡★，女，1985年生，河北省保定市人，解放军军医进修学院在读硕士，主要从事炎症性肠病基础与临床研究工作。zyf490@163.com
  • 基金资助:

    吴阶平医学基金会资助项目(320.6710.10001)。

Short-term effects of human umbilical cord-derived mesenchymal stem cells in treatment of patients with decompensated cirrhosis   

Zhang Yue-fan1, Li Nan2, Zhai Jun-shan2, Jiang Li-jun2, Cao Jian-ning3   

  1. 1Postgraduate Medical School of Chinese PLA, Beijing  100853, China; 2Department of Gastroenterology, the 309th Hospital of ChinesePLA, Beijing  100091, China; 3 Beike Bio- Technology Co., Ltd., Shenzhen  518057, Guangdong Province, China
  • Received:2011-10-09 Revised:2011-11-18 Online:2012-04-01 Published:2012-04-01
  • Contact: author: Li Nan, Doctor, Chief physician, Doctoral supervisor, Department of Gastroenterology, the 309th Hospital of Chinese PLA, Beijing 100091, China linan957@sina.com
  • About author:Zhang Yue-fan★, Studying for master’s degree, Postgraduate Medical School of Chinese PLA, Beijing 100853, China zyf490@163.com
  • Supported by:

    Wu Jieping Medical Foundation, No. 320.6710.10001*

PDF

427

被引次数

5

摘要：

背景：脐带间充质干细胞可分化为肝细胞样细胞。
目的：观察人脐带间充质干细胞移植治疗失代偿期肝硬化的近期临床效果。
方法：选择肝硬化失代偿期患者30例，对照组18例给予内科常规治疗，移植组12例在内科综合治疗基础上经肝动脉移植人脐带间充质干细胞悬液治疗。
结果与结论：移植后，移植组白蛋白有上升趋势，从第2周开始明显高于对照组(P < 0.05)，并持续至第12周；谷丙转氨酶和凝血酶原时间有下降趋势，从第8周开始明显低于对照组(P < 0.05)，并持续至第12周；总胆红素水平有下降趋势，从第4周开始明显低于对照组(P < 0.05)，并持续至第12周。两组临床症状、体征改善情况差异无显著性意义(P > 0.05)。说明经股动脉移植人脐带间充质干细胞是治疗失代偿期肝硬化近期有效。
关键词：肝硬化；脐带；间充质干细胞；失代偿期；肝动脉；移植
缩略语注释：UC-MSCs：human umbilical cord mesenchymal stem cells，人脐带间充质干细胞
doi:10.3969/j.issn.1673-8225.2012.14.024

关键词: 肝硬化, 脐带, 间充质干细胞, 失代偿期, 肝动脉, 移植

Abstract:

BACKGROUND: Umbilical cord-derived mesenchymal stem cells (UCMSCs) can differentiate into hapatocyte-like cells.
OBJECTIVE: To investigate short-time clinical effects of UCMSCs transplantation in treatment of patients with decompensated cirrhosis.
METHODS: Thirty patients with decompensated cirrhosis were involved. Eighteen patients in the control group were treated with conventional therapy, while twelve patients in the transplantation group were treated with UCMSCs transplantation via hepatic artery based on conventional therapy.
RESULTS AND CONCLUSION: After transplantation, albumin level in the transplantation group showed an ascend trend and had a significant increase (P < 0.05) compared with the control group from 2 weeks to 12 weeks of transplantation. Meanwhile, both alanine aminotransferase and prothrombin time levels began to decrease at 2 weeks after transplantation and were significantly lower than those of the control group (P < 0.05) from 8 weeks to 12 weeks of transplantation. In contrast to the controls, the level of total bilirubin in the transplantation group showed an ascend trend and had a significant increase (P < 0.05) from 4 weeks to 12 weeks of transplantation. The differences in clinical symptoms and signs between the two groups were not significant (P > 0.05). The transplantation of UC-MSCs via hepatic artery is effective in short time for treatment of patients with decompensated cirrhosis.

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