中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (47): 8887-8890.doi: 10.3969/j.issn.1673-8225.2011.47.037

• 生物材料综述 biomaterial review • 上一篇    下一篇

药物控释载体材料的研究与应用

王洪新, 陈晓明   

  1. 武汉理工大学生物材料与工程研究中心，湖北省武汉市  430070
  • 收稿日期:2011-05-16 修回日期:2011-06-20 出版日期:2011-11-19 发布日期:2011-11-19
  • 作者简介:王洪新☆，女，1976年生，辽宁省营口市人，汉族，武汉理工大学在读博士，主要从事生物材料研究。 whxqjz@163.com

Application and progress in the materials for drug controlled release

Wang Hong-xin, Chen Xiao-ming   

  1. Biomaterials and Engineering Research Center, Wuhan University of Technology, Wuhan  430070, Hubei Province, China
  • Received:2011-05-16 Revised:2011-06-20 Online:2011-11-19 Published:2011-11-19
  • About author:Wang Hong-xin☆, Studying for doctorate, Biomaterials and Engineering Research Center, Wuhan University of Technology, Wuhan 430070, Hubei Province, China whxqjz@163.com

PDF

774

被引次数

19

摘要：

背景：作为控制释放体系的药物载体材料大多是高分子材料，但部分纳米无机材料也正逐步应用到药物控释材料体系中并取得了很好的研究成果。因此，药物控释用载体材料的设计与研究应用越来越受到重视。
目的：对国内外药物控释载体材料的应用及最新研究进展作一综述。
方法：应用计算机检索CNKI和Elsevier SD数据库中1999-01/2011-01关于药物控缓释材料的文章，在标题和摘要中以“高分子，介孔材料，无机硅，磷酸盐，控释”或“polymer，mesoporous materials，Inorganic silicon ，calcium phosphate，controlled release”为检索词进行检索。选择文章内容与药物控缓释有关者，同一领域文献则选择近期发表或发表在权威杂志文章。纳入25篇文献进行综述。
结果与结论：药物控缓释载体材料以用药量小、作用时间长、靶向作用好等特点被广泛关注，但是仍存在载药后药物失活，丧失生物活性等缺陷，目前随着复合药物载体材料和经皮给药装置研究的发展，控缓释材料在临床治疗中的应用必将更加广泛。

关键词: 药物控释材料, 天然高分子, 人工合成高分子, 有序介孔材料, 纳米无机材料

Abstract:

BACKGROUND: Polymer materials play an important role in drug controlled release system. But nano-inorganic materials are studied as a new drug and gene controlled delivery carrier and appears to be very promising, so more considered are paied attention to the design and research of drug controlled release carrier materials.
OBJECTIVE: To summarize the applications and research progress of drug controlled release materials.
METHODS: Database of CNKI and Elsevier SD (1999-01/2011-01) were retrieved to search the related articles about the materials for drug controlled release using the keywords of “polymer, mesoporous materials, inorganic silicon, calcium phosphate, controlled release” in Chinese and English. Finally, 25 articles were included in review analysis.
RESULTS AND CONCLUSION: Drug controlled release carrier materials are widely drawn by their low dosage, long duration and good target effect. But there are still some deficiencies such as the drug inactivation and loss of biological activity after drug loading. The clinical application of drug controlled release carrier materials will be used more widely along with the development of composite carriers for drug delivery and transdermal drug delivery systems.

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