中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (42): 7939-7942.doi: 10.3969/j.issn.1673-8225.2011.42.035

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

冠状动脉药物涂层支架与置入后的血管再狭窄

刘晓峰   

  1. 南通大学附属海安医院，江苏省南通市 226604 
  • 收稿日期:2011-04-09 修回日期:2011-09-28 出版日期:2011-10-15 发布日期:2011-10-15
  • 作者简介:刘晓峰，男，1971年生，江苏省南通市人，1996年南通医学院毕业，副主任医师，主要从事心内科方面的研究。 logoyishengpai@126.com

Coronary drug-eluting stent and restenosis after implantation

Liu Xiao-feng   

  1. Haian Hospital of Nantong University, Nantong  226604, Jiangsu Province, China
  • Received:2011-04-09 Revised:2011-09-28 Online:2011-10-15 Published:2011-10-15
  • About author:Liu Xiao-feng, Associate chief physician, Haian Hospital of Nantong University, Nantong 226604, Jiangsu Province, China logoyishengpai@ 126.com

PDF

332

被引次数

8

摘要：

背景：近年来随着药物涂层支架研究的增多及临床应用不断扩大，使冠状动脉内支架置入后再狭窄率显著降低，且在预防再狭窄中较裸支架具有独特应用价值。
目的：阐述药物涂层支架的临床应用进展，并探讨支架的涂层材料、类型与置入后再狭窄的关系及与宿主的相容性。
方法：作者以“冠脉支架，金属支架，药物涂层支架，再狭窄”为检索词，在中国期刊全文数据库及Medline 数据库中，采用电子检索的方式进行文献检索。排除Meta分析及重复性研究，共检索到27篇文献。
结果与结论：药物涂层支架的确是介入心脏病学的一项重要突破，使介入心脏病学进入了一个新的时代，但其远期效果仍需进一步观察。各种药物涂层支架所含药物或含量不同，其作用机制不同，而且药物释放的速率也不同，所以药物涂层支架临床应用后的效用和安全性需要由严谨和大量的临床研究来证实。现今药物支架的载体材料经过长时间的人体腐蚀，材料本身会老化、脱落，在血管组织内形成小块，从而可能引起晚期的不良反应。如果采用生物可降解的材料作为药物载体材料，那么就有可能减少晚期不良反应的出现。因此，开发一种理想的支架系统，目前主要的研究方向是可降解的低致炎性聚合物材料以及高效的药物控释体系。

关键词: 冠状动脉, 金属支架, 药物涂层支架, 再狭窄, 生物相容性

Abstract:

BACKGROUND: Recently, the research and clinical application of drug-eluting stents continue to expand, so that coronary stent restenosis rate is significantly reduced, and the drug-eluting stents in the prevention of restenosis compared with bare stents has a unique value.
OBJECTIVE: To explain the clinical application of drug-eluting stents, and to explore the stent coating materials, stent types and correlation with restenosis after implantation, and compatibility with the host.
METHODS: A computer search of CNKI and Medline was performed using keywords of “coronary stents, metal stents, drug-eluting stents, restenosis”. Meta-analysis or repetitive articles were excluded, and 27 articles were included in result analysis.
RESULTS AND CONCLUSION: Drug-eluting stents is indeed a major breakthrough in interventional cardiology, but its long-term effect remains to be seen. Various drug-eluting stents containing different drugs in different concentrations, and their mechanisms are distinct as well as the drug release rates, so clinical effectiveness and safety of drug-eluting stents need the rigorous and extensive clinical studies. Today, stent carrier materials can age, loss, and form small tissues in blood vessels, resulting in late adverse reactions. Biodegradable materials as drug carrier materials are possible to reduce the appearance of late adverse reactions. Therefore, the development of an ideal stent system mainly focuses on low-inflammatory biodegradable polymer materials and efficient drug delivery system.

中图分类号: