中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (25): 4575-4578.doi: 10.3969/j.issn.1673-8225.2011.25.005

• 膜生物材料 membrane biomaterials • 上一篇    下一篇

均匀设计优选智能型密闭敷料支架基质配方

唐  娜1,2，邓  凌1，周立平1，郭  丽3，李  超2，蔡文智1   

  1. 1南方医科大学南方医院，广东省广州市  510515
    2广东医学院附属福田人民医院，广东省深圳市  518033
    3南方医科大学护理学院，广东省广州市   510515
  • 收稿日期:2010-10-02 修回日期:2011-01-10 出版日期:2011-06-18 发布日期:2014-01-10
  • 通讯作者: 蔡文智,主任护师，博士生导师， 南方医科大学南方医院，广东省广州市 510515 caiwzh@fimmu.com
  • 作者简介:唐娜★，女，1977年生，安徽省淮南市，回族，南方医科大学在读硕士，主管护师，主要从事临床护理、护理管理的研究。 prettymedictn@yahoo.com.cn
  • 基金资助:

    广东省自然科学基金项目(2004B30101019)。

Optimization of the matrix formulation of enclosed dressing intelligent scaffolds by uniform design

Tang Na1, 2, Deng Ling1, Zhou Li-ping1, Guo Li3, Li Chao2, Cai Wen-zhi1   

  1. 1Southern Hospital, Southern Medical University, Guangzhou  510515, Guangdong Province, China
    2Futian People's Hospital, Guangdong Medical College, Shenzhen  518033, Guangdong Province, China
    3School of Nursing, Southern Medical University, Guangzhou  510515, Guangdong Province, China
  • Received:2010-10-02 Revised:2011-01-10 Online:2011-06-18 Published:2014-01-10
  • Contact: Cai Wen-zhi, Chief superintendent nurse, Doctoral supervisor, Southern Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China caiwzh@fimmu.com
  • About author:Tang Na★, Studying for master’s degree, Nurse-in-charge, Southern Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China; Futian People's Hospital, Guangdong Medical College, Shenzhen 518033, Guangdong Province, China prettymedictn@yahoo.com.cn
  • Supported by:

    Natural Science Foundation of Guangdong Province, China, No. 2004B30101019*

PDF

288

被引次数

6

摘要：

背景：近年来创伤敷料的研究发展较快，但很少有中药联合高分子材料制备的复合密闭敷料，且现有的创伤敷料作用较局限，不能适用于任何创伤伤口，但怎样使高分子材料与中药完美的融合是目前一个热门的话题。
目的：优选智能型密闭敷料支架的最佳基质配方。
方法：采用均匀设计法结合SPSS 16.0软件进行多元线性回归分析，对敷料支架的吸水性、含水量、保湿性和外观评价等指标进行综合考察,优化智能型密闭敷料支架的基质设计。
结果与结论：通过实验数据分析，优选出智能型密闭敷料支架最佳基质配方比例为：壳聚糖∶明胶∶甘油∶聚乙烯醇∶聚乙二醇=8.3∶4.4∶3.1∶3.7∶1。提示智能型密闭敷料支架基质处方配比合理、制作工艺质量可控。

关键词: 智能型密闭敷料支架, 均匀设计, 基质配方, 高分子材料, 多元线性回归分析

Abstract:

BACKGROUND: In recent years, the wound dressing research has developed quickly, but few reports addressing the closed dressings prepared by traditional Chinese medicine combined with polymer composite, the efficacy of existing wound dressings is limited and not suitable for all wounds. But how to make polymer materials and traditional Chinese medicine to mix perfectly is a hot topic recently.
OBJECTIVE: To optimize the matrix formulation of enclosed dressing intelligent scaffolds.
METHODS: Multiple regression analysis with uniform design and SPSS 16.0 software was used to optimize the matrix formulation of enclosed dressing intelligent scaffolds and survey the aspects comprehensively, such as water absorption of dressing scaffolds, moisture content, relative moisture retention, hand evaluation indicators and so on.
RESULTS AND CONCLUSION: The optimum dressing scaffolds matrix formulation ratio was as follows: chitosan: gelatin: glycerol: polyvinyl alcohol: polyethylene glycol = 8.3∶4.4∶3.1∶3.7∶1, according to analysis of experimental data. It is indicated that the prescription ratio of the matrix formulation of enclosed dressing intelligent scaffolds is feasible. In addition, the technique of the enclosed dressing intelligent scaffolds is steerable.

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