中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (14): 2641-2644.doi: 10.3969/j.issn.1673-8225.2011.14.038

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞免疫学特性及其移植治疗脊髓损伤

刘  筱1，许  铁2   

  1. 1徐州医学院，江苏省徐州市221002
    2徐州医学院附属医院急救中心，江苏省徐州市  221002
  • 收稿日期:2010-10-19 修回日期:2010-12-09 出版日期:2011-04-02 发布日期:2013-11-02
  • 通讯作者: 许铁，硕士生导师，主任医师，教授，徐州医学院附属医院急救中心，江苏省徐州市221002 xutie889@163.com
  • 作者简介:刘筱★，男，1983年生，江苏省丰县人，汉族，硕士，医师，主要从事骨髓间充质干细胞及脊髓损伤修复的研究。 liuxiao628@hotmail.com

Immunological characteristics and transplantation of bone marrow mesenchymal stem cells in treatment of spinal cord injury 

Liu Xiao1, Xu Tie2   

  1. 1Xuzhou Medical College, Xuzhou  221002, Jiangsu Province, China
    2Emergency Care Center, Hospital Affiliated to Xuzhou Medical College, Xuzhou  221002, Jiangsu Province, China
  • Received:2010-10-19 Revised:2010-12-09 Online:2011-04-02 Published:2013-11-02
  • Contact: Xu Tie, Master’s supervisor, Chief physician, Professor, Emergency Care Center, Hospital Affiliated to Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China xutie889@163.com
  • About author:Liu Xiao★, Master, Physician, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China liuxiao628@hotmail.com

PDF

394

被引次数

12

摘要：

背景：近年来研究表明：骨髓间充质干细胞能在同种异基因，甚至异种基因的环境中长期存活，并且保持多向分化潜能。这一独特的免疫学特性，以及来源丰富、避免伦理问题等优点，可能为治疗脊髓损伤和促进神经功能修复提供了新的途径。
目的：对骨髓间充质干细胞的免疫学特性、不同途径移植及其可能机制进行综述，为干细胞治疗脊髓损伤提供理论依据。
方法：由第一作者应用计算机检索PubMed 2000-01/2010-09期间相关文章，检索词为“mesenchymal stem cells，bone marrow，immunological characteristics，transplantation，spinal cord injury”。纳入标准：文章所述内容应与骨髓间充质干细胞的免疫学特性及其治疗相关研究进展。排除标准：重复研究或者Meta分析类文章。共收集到260篇相关文献，选取33篇文献进入结果分析。
结果与结论：骨髓间充质干细胞具有独特的低免疫原性，有助于抑制移植排斥反应。通过不同的移植方法、选择合适的移植途径和时机，均可对脊髓损伤的治疗提供有益的保护作用，其机制可能是神经元替代、分泌神经营养因子、归巢效应等。随着对骨髓间充质干细胞和脊髓损伤机制研究的不断深入，预示着间充质干细胞移植在治疗脊髓损伤后神经功能修复领域，将有着广阔的临床应用前景。

关键词: 脊髓损伤, 骨髓间充质干细胞, 免疫学特性, 移植, 文献综述

Abstract:

BACKGROUND: Previous studies have confirmed that bone marrow mesenchymal stem cells (BMSCs) can be also transplanted into allogeneic and heterologous gene environment, and maintain multi-directional differentiation potential. It may provide a new path to promote nerve repair after spinal cord injuries for its rich source, avoidance of ethical problem and distinct immunological characteristics.
OBJECTIVE: To summarize the immunological characteristics, different pathways of transplantation and its possible mechanisms of BMSCs and to provide theoretical evidence for stem cells in treatment of spinal cord injury.
METHODS: Related articles on PubMed from January 2000 to September 2010 were searched by the first author with the key words of “mesenchymal stem cells, bone marrow, immunological characteristics, transplantation, spinal cord injury” in English. Inclusion criterion: the articles related to the immunological characteristics of BMSCs and research progress of its treatment. Exclusion criteria: the articles with repetitive research or Meta analysis. 260 relevant articles were selected and 33 of them were included.
RESULTS AND CONCLUSION: BMSCs have low immunogenicity and can suppress the immunoreaction after transplantation. Migration through different methods, choosing the right migration path and timing may provide useful protection for the treatment of spinal cord injury. The mechanism may include neuron substitute, neurotrophic factor secretion, homing effect and so on. With the deep research of BMSCs and the mechanism of spinal cord injury, it will have a bright future in the field of clinical application after spinal cord injury.

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