中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (7): 1277-1280.doi: 10.3969/j.issn.1673-8225.2011.07.031

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

雷帕霉素靶蛋白信号转导在调节肌肉体积中的作用

黄江林1，徐  飞2   

  1. 1 贵州师范大学体育学院，贵州省贵阳市  550001
    2 浙江工业大学体军部，浙江省杭州市  310014
  • 收稿日期:2010-08-27 修回日期:2010-11-04 出版日期:2011-02-12 发布日期:2011-02-12
  • 作者简介:黄江林★，男，湖北省随州市人，汉族，2006年湖北大学毕业，硕士，讲师，主要从事体育教育训练学与运动生理学研究。 koukoushan@ sohu.com

Role of rapamycin target protein signal transduction in regulating muscle volume

Huang Jiang-lin1, Xu Fei2   

  1. 1Institute of Physical Education, Guizhou Normal University, Guiyang  550001, Guizhou Province, China
    2Department of Physical and Military Education, Zhejiang University of Technology, Hangzhou  310014, Zhejiang Province, China
  • Received:2010-08-27 Revised:2010-11-04 Online:2011-02-12 Published:2011-02-12
  • About author:Huang Jiang-lin★, Master, Lecturer, Institute of Physical Education, Guizhou Normal University, Guiyang 550001, Guizhou Province, China koukoushan@sohu. com

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324

被引次数

2

摘要：

背景：虽然抗阻训练在康复训练中广泛应用，但其调节生长发育和萎缩状态下肌肉再生的信号转导通路迄今仍未阐明，近期有证据表明雷帕霉素靶蛋白通路在此方面具有一定作用。
目的：回顾分析雷帕霉素靶蛋白与雷帕霉素靶蛋白通路及抗阻训练中雷帕霉素靶蛋白信号转导通路调节肌肉体积的重要作用。
方法：由第一作者检索1985/2008 PubMed数据库有关雷帕霉素靶蛋白研究起源、介导通路上下游蛋白及与抗阻运动相关的生理效应等方面的文献。
结果与结论：蛋白激酶B/雷帕霉素靶蛋白信号通路可通过增加蛋白质合成而调节肌肉生长，但需要指出的是，虽然雷帕霉素靶蛋白及其下游通路的活化对功能性超负荷后的肌肉生长具有重要作用，但肌肉萎缩后的再生长也可能取决于雷帕霉素靶蛋白之外的其他通路。未来的研究需要进一步探讨雷帕霉素靶蛋白通路调节正常和萎缩肌肉中负荷诱导肌纤维生长的作用，细胞生长与营养、生长因子和细胞能量等信号与机械负荷过程中雷帕霉素靶蛋白活性调节的相关程度，以及将外部信号翻译成肌肉体积变化的关键信号转导通路。

关键词: 雷帕霉素靶蛋白, 信号转导, 抗阻训练, 肌肉体积, 分子机制

Abstract:

BACKGROUND: Resistance exercise has been widely used in rehabilitation training, but its signal transduction pathway in regulating growth and development and atrophy muscle regeneration remains poorly understood. Mammalian target of rapamycin (mTOR) has been proved has certain effect.
OBJECTIVE: To retrospective analyze the role of mTOR, mTOR protein pathway and mTOR signal transduction in regulating muscle volume during resistance exercise.
METHODS: PubMed database (1985-2008) was searched by the first author for literatures regarding origin of mTOR protein, upstream and downstream proteins in signal pathway.
RESULTS AND CONCLUSION: Akt/mTOR signal pathway can adjust the growth of muscles by increasing protein synthesis, but it should be pointed out that, regrowth of atrophied muscles may depend on other pathways although mTOR pathway plays an important role in the growth of muscles. In further researches the following should be discussed such as the function of mTOR to induce the phenotypic growth of the regular and atrophied muscles, the relationship between regulation of mTOR under the load and signals such as cell growth and nutrition, growth factor and cellular energy, and signal transduction pathway of external signals turned into ones about the change of muscle mass.

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