中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (42): 7919-7922.doi: 10.3969/j.issn.1673-8225.2010.42.031

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

脊髓防粘连膜的生物相容性与可降解性

鞠传广   

  1. 山东省文登市整骨医院脊柱脊髓科, 山东省文登市264400
  • 出版日期:2010-10-15 发布日期:2010-10-15
  • 作者简介:鞠传广★，男，1967年生，山东省文登市人，汉族，硕士，副主任医师，主要从事脊柱脊髓方面的研究。 wdzgjcg@163.com

Biocompatibility and biodegradability of spinal cord anti-adhesion membrane

Ju Chuan-guang   

  1. Department of Spine and Spinal Cord, Wendeng Orthopaedics Hospital, Wendeng   264400, Shandong Province, China
  • Online:2010-10-15 Published:2010-10-15
  • About author:Ju Chuan-guang★, Master, Associate chief physician, Department of Spine and Spinal Cord, Wendeng Orthopaedics Hospital, Wendeng 264400, Shandong Province, China wdzgjcg@163.com

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424

被引次数

3

摘要：

目的：评价组织工程材料脊髓防粘连膜的生物相容性及可降解性。
方法：第一作者应用计算机检索PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)及CNKI数据库(www.cnki.net/index.htm)，以“生物相容性；壳聚糖；脊髓；生物材料”或“Biocompatibility; chitosan; spinal cord; biological materials”为检索词进行检索。选择文章与检索关键词材料学特点、生物相容性及其应用效果相关，同一领域文献则选择近期发表或发表在权威杂志文章。共纳入42篇文献。
结果：预防和减少经椎管内脊柱手术术后硬膜外瘢痕粘连一直是脊柱外科的研究热点。植入防粘连材料是预防和减少硬膜外瘢痕粘连的主要方法。理想的防粘连材料应该具有良好的生物相容性，无炎症反应，不产生排斥；能有效地覆盖手术部位,防止纤维组织长入，降解时间适当，无毒副作用等。壳聚糖是一类极具发展潜力的天然生物材料，其在生物医药材料中的研究以及应用越来越受到重视。
结论：壳聚糖是一类具有良好生物相容性的材料，可以发挥预防椎板切除术后硬膜外粘连的优势，同时可明显抑制椎板切除术后硬膜外胶原组织的增生及代谢，从而减少瘢痕组织的形成，在组织工程研究中有广阔的应用前景。

关键词: 壳聚糖, 生物相容性, 脊髓, 生物材料, 防粘连膜

Abstract:

OBJECTIVE: To evaluate the biocompatibility and biodegradability of tissue engineering material spinal cord anti-adhesion membrane.
METHODS: A computer search of PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI Database (www.cnki.net/index.htm) was performed by the first author using “biocompatibility; chitosan; spinal cord; biological materials” in English and in Chinese as key words. Articles related to the materials science, biocompatibility and application of the key words were included, those recently published or published in the authority journals were preferred in the same field. A total of 42 literatures were involved.
RESULTS: Prevention and reduction of epidural scar adhesion after spinal surgery have been a research focus. Anti-adhesion material implanted is the main method of preventing and reducing epidural scar adhesion. Ideal anti-adhesion materials should have good biocompatibility, no inflammatory response, no rejection; can effectively cover the surgical site, prevent fibrous tissue ingrowth, degrade for appropriate time, have no toxic side effects. Chitosan is a class of potential developing natural biological materials, and obtains more and more attention for the application in biomedical research.
CONCLUSION: Chitosan is a type of materials with good biocompatibility and can play a preventive role on epidural adhesion after laminectomy, and remarkably inhibit the epidural collagen proliferation and metabolism after laminectomy, thereby reducing the formation of scar tissue, has broad application prospects in tissue engineering research.

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