中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (4): 653-656.doi: 10.3969/j.issn.1673-8225.2011.04.019

• 数字化骨科 digital orthopedics • 上一篇    下一篇

人体皮肤微血管构筑的三维可视化

郭志勇1，丁红梅2，尹知训1，董伟强1，白  波1，彭田红3   

  1. 1 广州医学院第一附属医院骨科，广东省广州市  510120
    2广州医学院解剖学教研室，广东省广州市  510515
    3南华大学解剖学教研室，湖南省衡阳市  421200
  • 收稿日期:2010-07-23 修回日期:2010-08-28 出版日期:2011-01-22 发布日期:2011-01-22
  • 通讯作者: 尹知训，博士，副主任医师，广州医学院第一附属医院骨科，广东省广州市 510120 yzhixun@163.com
  • 作者简介:郭志勇，男，1973年生，广东省英德县人，汉族，1998年天津医科大学毕业，主治医师，主要从事创伤骨科、数字骨科方面的研究。
  • 基金资助:

    广东省医学科学技术研究基金(WSTJJ20081125432928196601020416)，课题名称：皮肤血管体三维可视化研究与临床应用。

Three-dimensional visualization of human cutaneous microvasculature 

Guo Zhi-yong1, Ding Hong-mei2, Yin Zhi-xun1, Dong Wei-qiang1, Bai Bo1, Peng Tian-hong3   

  1. 1Department of Orthopaedic Surgery, First Affiliated Hospital of Guangzhou Medical College, Guangzhou  510120, Guangdong Province, China
    2Department of Anatomy, Guangzhou Medical College, Guangzhou  510515, Guangdong Province, China
    3Department of Anatomy, University of South China, Hengyang  421200, Hunan Province, China
  • Received:2010-07-23 Revised:2010-08-28 Online:2011-01-22 Published:2011-01-22
  • Contact: Yin Zhi-xun, Doctor, Associate chief physician, Department of Orthopaedic Surgery, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, Guangdong Province, China yzhixun@163.com
  • About author:Guo Zhi-yong, Attending physician, Department of Orthopaedic Surgery, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, Guangdong Province, China
  • Supported by:

    the Medical Science and Technology Research Foundation of Guangdong Province, No. WSTJJ20081125432928196601020416*

PDF

539

被引次数

11

摘要：

背景：常用的血管解剖学研究方法如逐层解剖、血管染色、造影摄片可以确定血管的位置、大至供血范围等，但难以显示皮肤微血管立体构筑。
目的：建立三维的皮肤微血管构筑模型，以评估和设计穿支皮瓣。
方法：选取2具新鲜成人尸体标本，以羧甲基纤维素明胶氧化铅灌注标识血管，CT扫描获取标本灌注前后及剥离皮肤序列图像数据，利用Mimics13.1软件进行皮肤微血管三维重建和穿支皮瓣设计。
结果与结论：实验成功重建了骨骼、血管、皮肤三维数字模型，并选择性设计了旋股外侧动脉皮瓣和旋肱后动脉的主要穿支皮瓣。构建的皮肤微血管模型不仅可显示皮穿支的长度管径、立体位置、走行方向、分布范围、毗邻关系，还可追踪其来源血管，与来源血管、骨骼、皮肤等搭配显示。说明皮肤微血管构筑可揭示穿支皮瓣的范围和扩张方向，有利于穿支皮瓣的设计发掘、血供评估。

关键词: 微血管构筑, 穿支皮瓣, 三维可视化, 血管组织工程

Abstract:

BACKGROUND: Angiotomy methods such as dissection, ink injection and angiographs techniques have been used to identify vessel location. However, these techniques rarely provide a steric architecture of the cutaneous angiosome.
OBJECTIVE: To establish three-dimensional (3D) architecture of the cutaneous angiosome for assessing and designing perforator flaps.
METHODS: Two fresh cadavers were injected with carboxymethyl cellulose/lead oxide and subjected to CT scanning before and after the injection to obtain data of the cutaneous and subcutaneous tissue derived from one injected cadaver. Three-dimensional reconstruction and perforator flaps design were performed using Mimics13.1 software.
RESULTS AND CONCLUSION: Three-dimensional digital models of the bone, blood vessels, skin were obtained. The flap with total perforator of external femoral circumflex artery and the flap with main perforator of posterior humeral circumflex artery were developed. The 3D microvascular architecture model can clearly display the spatial location, distribution range and anastomose relationship of the cutaneous perforators, the caliber, length, position of particular source artery in the exact spatial location. As a result, it visualized the general area and expandable direction of a respective flap. This technique facilitates perforator flaps design and blood supply evaluation.

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