中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (53): 10011-10015.doi: 10.3969/j.issn.1673-8225.2010.53.032

• 器官移植学术探讨 academic discussion of organ transplantation • 上一篇    下一篇

静脉桥血管材料——大隐静脉移植后再狭窄的治疗进展　

王文俊，刘季春   

  1. 南昌大学第一附属医院心胸外科，江西省南昌市  330006
  • 出版日期:2010-12-31 发布日期:2010-12-31
  • 通讯作者: 刘季春，博士，主任医师，教授，博士生导师，南昌大学第一附属医院心胸外科，江西省南昌市 330006
  • 作者简介:王文俊★，男，1983年生，江西省樟树市人，汉族，南昌大学在读硕士，主要从事心脏冠脉搭桥再狭窄研究。 piaojunwen@sina.com
  • 基金资助:

    课题获国家自然基金项目(30760247，30960380)资助。

Vein graft materials: Progress in restenosis treatment following vein graft transplantation

Wang Wen-jun, Liu Ji-chun   

  1. Department of Cardiothoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang  330006, Jiangxi Province, China
  • Online:2010-12-31 Published:2010-12-31
  • Contact: Liu Ji-chun, Doctor, Chief physician, Professor, Doctoral supervisor, Department of Cardiothoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
  • About author:Wang Wen-jun★, Studying for master’s degree, Department of Cardiothoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China piaojunwen@sina.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30760247*, 30960380*

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摘要：

背景：随着再狭窄机制研究的深入，各种治疗方法的进一步完善以及多种方法的联合应用，有效预防静脉桥狭窄将成为现实。
目的：介绍静脉桥病变的多种病因及预防迟发性静脉桥狭窄的新方法。
方法：分别以“心脏外科学；静脉移植；再狭窄；防治”，“ Heart Surgery; vein transplantation；restenosis；prevention”为检索词，应用计算机检索重庆维普(VIP)期刊全文数据库，中国知网数据库，Pubmed 数据库及highwire全文数据库1995-01/2009-12有关文章。纳入有关静脉移植再狭窄的文献，排除与研究目的无关和内容重复者，保留40篇文献做进一步分析。
结果与结论：对于冠状动脉左主干和多支血管严重病变者，外科冠状动脉搭桥术仍是目前主要的治疗手段。但作为桥血管材料——大隐静脉，移植后再狭窄率比较高，给临床治疗带来了许多不便。文章从静脉桥病变的多种病因，预防迟发性静脉桥狭窄新方法，包括保守治疗、手术预防、血管外支架、药物治疗、基因治疗及激光和放射治疗等进行了归纳总结。

关键词: 大隐静脉, 心脏外科学, 静脉移植, 再狭窄, 防治, 综述文献

Abstract:

BACKGROUND: It is may become a reality to prevent vein graft stenosis effectively with in-depth study of the mechanism of restenosis, further improvement of various treatment methods and the joint application.
OBJECTIVE: To introduce the multiple causes of vein graft lesions and to explore new method for the prevention of delayed vein graft stenosis.
METHODS: Using computer technology to retrieve the articles in VIP periodical full-text database, CNKI database, highwire full-text database and PubMed database published between January 1995 and December 2009 with key words of “heart surgery, vein transplantation, restenosis, prevention”. Literatures with regard to vein graft transplantation were included. Irrelevant and repetitive contents were excluded. Totally 40 literatures were selected for the further analysis. 
RESULTS AND CONCLUSION: Surgical coronary artery bypass graft surgery is the main treatment for the patients suffered from left main coronary artery and severe multi-vessel lesions. However, great saphenous vein is a kind of graft material, and the postoperative restenosis rate is relatively high, which brings a lot of inconvenience for the clinical treatment. This paper summarizes the multiple causes of vein graft lesions and to explore new method for preventing delayed vein graft stenosis from the aspects of conservative treatment, surgery prevention, extravascular stent, drug therapy, gene therapy and laser and radiation therapy.

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