中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (9): 2391-2402.doi: 10.12307/2026.063

• 植入物相关大数据分析 Implant related big data analysis • 上一篇    下一篇

椎间盘再生与修复领域研究热点与前沿信息的可视化分析

朱小龙1，2，张  玮1，3，杨  阳1，3   

  1. 1江西中医药大学，江西省南昌市   330000；2杭州市富阳中医骨伤医院，浙江省杭州市   311400；3江西中医药大学附属医院，江西省南昌市   330000
  • 收稿日期:2024-12-30 接受日期:2025-04-03 出版日期:2026-03-28 发布日期:2025-09-29
  • 通讯作者: 张玮，博士，主任中医师，博士生导师，江西中医药大学，江西省南昌市 330000；江西中医药大学附属医院，江西省南昌市 330000
  • 作者简介:朱小龙，男，1988年生，安徽省五河县人，汉族，江西中医药大学在读博士，主治中医师，主要从事脊柱退行性疾病治疗方面的研究。
  • 基金资助:
    杭州市医药卫生科技项目合同(B20220070)，项目负责人：朱小龙

Visualization analysis of research hotspots and cutting-edge information in the field of intervertebral disc regeneration and repair

Zhu Xiaolong1, 2, Zhang Wei1, 3, Yang Yang1, 3   

  1. 1Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, Jiangxi Province, China; 2Fuyang Traditional Chinese Medicine Orthopedic Hospital, Hangzhou 311400, Zhejiang Province, China; 3Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330000, Jiangxi Province, China
  • Received:2024-12-30 Accepted:2025-04-03 Online:2026-03-28 Published:2025-09-29
  • Contact: Zhang Wei, PhD, Chief physician, Doctoral supervisor, Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, Jiangxi Province, China; Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330000, Jiangxi Province, China
  • About author:Zhu Xiaolong, Doctoral candidate, Attending physician, Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, Jiangxi Province, China; Fuyang Traditional Chinese Medicine Orthopedic Hospital, Hangzhou 311400, Zhejiang Province, China
  • Supported by:
    Hangzhou Medical and Health Science and Technology Project, No. B20220070 (to ZXL)

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摘要：

文题释义：

椎间盘退变：是指脊柱中的椎间盘因年龄增长、机械应力、遗传因素或不良生活习惯等原因，使合成代谢与分解代谢长期失衡导致椎间盘蛋白多糖和水合作用的逐渐丧失进而改变其组成，具体表现包括椎间盘纤维环的弹性降低和破裂、髓核脱水及移位、椎间盘高度减少，以及细胞外基质成分的变化，最终导致椎管狭窄、脊柱不稳、腰腿痛等疾病。
文献可视化分析：是一种通过图形化手段对大量文献数据进行整理、分析和展示的方法，其目的是揭示学术研究领域中的知识结构、发展趋势、研究热点以及关键作者和机构之间的关系。通过可视化分析，研究者能够更直观地理解和把握某一研究领域的全貌，辅助决策和战略规划。

摘要
背景：近年来，干细胞、外泌体、生物材料等新兴技术的快速发展，为椎间盘再生疗法的实现提供了多元化路径与可行性。
目的：对椎间盘再生与修复研究领域的热点进行文献可视化分析，总结该领域研究的发展历程、研究现状及研究热点，以期为今后的进一步研究提供参考。
方法：通过选择Web of Science核心合集数据库，并运用Citespace 6.4.R1与VOSviewer 1.6.20软件对相关国家、机构、关键词共现分析、聚类分析、突现分析、时间线分析、文献共被引分析、文献突现分析以及科研合作网络进行全面分析，借助可视化技术，呈现出该研究领域的知识结构、学术社群及技术演化趋势，从而对椎间盘修复与再生领域的研究状态与前沿动向形成全面、客观的认知。
结果与结论：①共纳入1 229篇文献，近15年来相关研究的发文量总体呈逐年上升趋势，在2023年达到高峰163篇；发文数量最多的国家是中国，共687篇；发文数量最多的机构是上海交通大学，共61篇；合作作者分析发现发文量和被引次数均排名第一的是来自美国西奈山伊坎医学院的Iatridis,james c学者，发表33篇，平均每篇被引50.54次；作者合作分析图谱可以发现尽管椎间盘再生与修复研究存在一定的地域性差异，但跨国合作的作者数量不容忽视。②文献共被引分析发现被引次数最多的是Nebojsa Nick Knezevic学者在2021年发表在《Lancet》杂志的一篇文章，被引了61次；在文献共被引频次排名前10的文献中，有6篇聚焦于干细胞、内源性修复细胞以及组织工程等领域；在文献共被引突现强度排名前10的文献中，有3篇专注于干细胞治疗椎间盘退变的研究，另有4篇则集中于组织工程生物材料的研究，涵盖水凝胶和生物支架等领域。③关键词共现及聚类分析结果可见4个聚类方向：椎间盘结构与组织工程(15个项目)，椎间盘退变的机制(13个项目)，椎间盘退变的研究模型建立与治疗策略(5个项目)，干细胞与再生医学(5个项目)，可见目前椎间盘修复领域主要以是延缓或逆转椎间盘退变进程的治疗方案为主。④在前20位关键词的突现分析中，关键词“氧化应激”展现出最高的突现强度；此外，关键词如“通路”“应激”“髓核细胞”“氧化应激”“炎症”和“细胞外囊泡”的突现尚未结束，表明这些领域仍然是近年来的研究热点。关键词时间线图分析结果表明，“氧化应激”长期以来一直是椎间盘修复与再生研究领域的热点，“外泌体”是近年才逐渐受到关注的新兴研究方向，“间充质干细胞”“纤维环修复”和“组织工程”相关研究则较早进入学者视野，目前仍然是该领域的研究热点和重点。⑤可视化分析结果显示，椎间盘修复与再生领域的研究在全球范围内呈现出快速发展的趋势。目前，该领域的技术进展主要体现在对椎间盘再生与修复方法的多元化探索，此外，研究人员针对椎间盘退变机制的干预措施提出了多种创新方案，展示了该领域未来治疗方法的广阔前景。


中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

关键词: 椎间盘退变, 椎间盘修复, 纤维环修复, 文献计量学, 可视化分析, 研究热点

Abstract: BACKGROUND: In recent years, the rapid development of emerging technologies such as stem cells, exosomes, and biomaterials has provided diversified approaches and feasibility for the realization of intervertebral disc regeneration therapies.
OBJECTIVE: To conduct a bibliometric visualization analysis of research hotspots in the field of intervertebral disc regeneration and repair, summarize the developmental trajectory, current status, and research hotspots in this domain, thereby providing a reference for future research.
METHODS: By selecting the Web of Science Core Collection database and utilizing Citespace 6.4.R1 and VOSviewer 1.6.20 software, a comprehensive analysis was performed on relevant countries, institutions, keyword co-occurrence, clustering analysis, burst analysis, timeline analysis, document co-citation analysis, citation burst analysis, and scientific collaboration networks. Visualization techniques were employed to reveal the knowledge structure, academic communities, and technological evolution trends in this research field, thereby forming a comprehensive and objective understanding of the research status and frontier dynamics in intervertebral disc repair and regeneration.
RESULTS AND CONCLUSION: (1) A total of 1 229 articles were included, and the number of publications related to this field has shown an overall increasing trend over the past 15 years. The annual number of publications reaches a peak of 163 in 2023. China is the country with the highest number of publications, contributing 687 articles, while Shanghai Jiao Tong University is the leading institution with 61 publications. Author collaboration analysis reveals that James C. Iatridis from the Icahn School of Medicine at Mount Sinai in the United States ranks first in both publication volume and citation count, with 33 publications, averaging 50.54 citations per article. The author collaboration network indicates that despite regional differences in intervertebral disc regeneration and repair research, the number of international collaborations is significant. (2) Co-citation analysis identified the most cited article as one by Nebojsa Nick Knezevic published in Lancet in 2021, which was cited 61 times. Among the top 10 most co-cited articles, six focus on stem cells, endogenous repair cells, and tissue engineering. In the top 10 articles ranked by citation burst strength, three concentrate on stem cell therapy for intervertebral disc degeneration, while four focus on tissue engineering biomaterials, including hydrogels and biological scaffolds. (3) Keyword co-occurrence and cluster analysis revealed four main research directions: Intervertebral disc structure and tissue engineering (15 items), mechanisms of intervertebral disc degeneration (13 items), establishment of research models and treatment strategies for intervertebral disc degeneration (5 items), and stem cells and regenerative medicine (5 items). The analysis suggests that current research in intervertebral disc repair primarily focuses on treatments aimed at delaying or reversing the progression of disc degeneration. (4) In the top 20 keywords ranked by burst strength, “oxidative stress” exhibited the highest burst intensity. Keywords such as “pathway,” “stress,” “nucleus pulposus cells,” “oxidative stress,” “inflammation,” and “extracellular vesicles” continue to show active bursts, indicating that these areas remain recent research hotspots. Timeline analysis of keywords shows that “oxidative stress” has long been a focal point in intervertebral disc repair and regeneration research. In contrast, “exosomes” have emerged as a new research direction only in recent years. Research on “mesenchymal stem cells,” “annulus fibrosus repair,” and “tissue engineering” has been established earlier and remains a key focus in the field. (5) Through visualization analysis, the field of intervertebral disc repair and regeneration has shown rapid global development. Current technological advancements are primarily reflected in the diversified exploration of regeneration and repair methods. Additionally, researchers have proposed various innovative approaches targeting the mechanisms of intervertebral disc degeneration, demonstrating the broad prospects for future therapeutic methods in this field. 

Key words: intervertebral disc degeneration, intervertebral disc repair, annulus fibrosus repair, bibliometrics, visualization analysis, research hotspots 

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