中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (11): 2920-2932.doi: 10.12307/2026.074

• 组织构建相关数据分析 Date analysis of organization construction • 上一篇    下一篇

焦虑抑郁在慢性阻塞性肺疾病领域的研究现状、趋势和热点

王佳瀛，徐  春，玛依拉·阿不都克力木   

  1. 新疆医科大学第六附属医院呼吸与危重症医学科，新疆维吾尔自治区乌鲁木齐市   830002


  • 收稿日期:2025-03-06 接受日期:2025-05-11 出版日期:2026-04-18 发布日期:2025-09-10
  • 通讯作者: 玛依拉·阿不都克力木，硕士生导师，主任医师，新疆医科大学第六附属医院呼吸与危重症医学科，新疆维吾尔自治区乌鲁木齐市 830002
  • 作者简介:王佳瀛，女，2000年生，四川省成都市人，汉族，在读硕士，主要从事慢性阻塞性肺疾病合并症研究。
  • 基金资助:
    国家自然科学基金项目(62266041)，项目负责人：徐春

Global research status, trends and hotspots of anxiety/depression in chronic obstructive pulmonary disease

Wang Jiaying, Xu Chun, Mayila · Abudukelimu   

  1. Department of Respiratory and Critical Care Medicine, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830002, Xinjiang Uygur Autonomous Region, China
  • Received:2025-03-06 Accepted:2025-05-11 Online:2026-04-18 Published:2025-09-10
  • Contact: Mayila Abudukelimu, Master’s supervisor, Chief physician, Department of Respiratory and Critical Care Medicine, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830002, Xinjiang Uygur Autonomous Region, China
  • About author:Wang Jiaying, MS candidate, Department of Respiratory and Critical Care Medicine, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830002, Xinjiang Uygur Autonomous Region, China
  • Supported by:
    the National Natural Science Foundation of China, No. 62266041 (to XC)

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摘要：


文题释义：
慢性阻塞性肺疾病：是一种异质性肺部疾病，以慢性呼吸系统症状(呼吸困难、咳嗽、咳痰)为特征，是由于气道异常(支气管炎、细支气管炎)和/或肺泡异常(肺气肿)导致的持续性(常为进展性)气流阻塞。
文献计量学：是一门综合学科，融合了文献学、数学、统计学的原理和方法，能科学、准确、高效地探索和分析大量科学数据，解开某领域不同阶段的发展差别，揭示其新兴热点，从海量文献中把握最新趋势。常用的文献计量学工具包括CiteSpace、VOSviewer等。

背景：焦虑抑郁是慢性阻塞性肺疾病患者常见的重要并发症之一，与不良的健康状况和预后有关，目前慢性阻塞性肺疾病合并焦虑抑郁相关领域越来越受到关注。
目的：从文献计量学角度分析慢性阻塞性肺疾病合并焦虑抑郁相关研究的全球研究现状，探讨该研究领域的热点与趋势。
方法：基于Web of Science核心合集数据库，使用检索式TS=(“Chronic obstructive pulmonary disease” AND “anxiety”) OR TS=(“Chronic obstructive pulmonary disease”AND “depression”) 检索2015-01-01/2024-11-01发表的相关文献，利用CiteSpace和VOSviewer从年度发文量、国家、所属机构、作者及期刊等维度进行数据分析和可视化图谱说明。
结果与结论：2015-2024年，慢性阻塞性肺疾病和焦虑或抑郁相关研究领域共发表了1 763篇文献，这些文献来自83个国家的9 616名作者，发表在623个期刊上。在慢性阻塞性肺疾病和焦虑或抑郁相关研究领域，美国发表数量最多，其次是中国；《International Journal of Chronic Obstructive Pulmonary Disease》是最具影响力的期刊；作者M.A. Spruit和马斯特里赫特大学分别是最具生产力的作者和机构，但研究者集群尚未达到一定规模情况，未来团队合作仍有待加强。全球研究焦点主要集中在姑息治疗、慢性阻塞性肺疾病、心理健康、心血管疾病、全身炎症反应、慢性病、慢性疼痛、心力衰竭、肺康复、慢性阻塞性等10个主题群，该领域研究热点经历了临床表型-分子机制-系统干预的迁移变革，未来应在此基础上融合多学科技术实现筛查、诊断与治疗的精准医疗，优化慢性阻塞性肺疾病及其合并焦虑抑郁的管理策略。
https://orcid.org/0009-0008-7246-5620 (王佳瀛) 

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 慢性阻塞性肺疾病, 焦虑, 抑郁, 文献计量学, 研究热点

Abstract: BACKGROUND: Anxiety and depression are among the common and significant comorbidities in patients with chronic obstructive pulmonary disease, associated with poor health status and prognosis. Research on chronic obstructive pulmonary disease combined with anxiety and depression has garnered increasing attention.
OBJECTIVE: From a bibliometric perspective, to analyze the global research landscape of chronic obstructive pulmonary disease with comorbid anxiety and depression, and to investigate the research hotspots and emerging trends in this field.
METHODS: Relevant literature published from January 1, 2015 to November 1, 2024 was retrieved from the Web of Science Core Collection database using the search query: TS=(“Chronic obstructive pulmonary disease” AND “anxiety”) OR TS=(“Chronic obstructive pulmonary disease” AND “depression”). CiteSpace and VOSviewer were utilized to analyze and visualize the data, including annual publication trends, contributions by countries, institutions, authors, and journals.
RESULTS AND CONCLUSION: During the 2014–2024 period, a total of 1 763 publications were identified in the research domain of chronic obstructive pulmonary disease comorbid with anxiety or depression. These works were authored by 9 616 authors from 83 countries and disseminated across 623 journals, demonstrating global collaborative engagement. The United States emerged as the most productive country, followed by China. The International Journal of Chronic Obstructive Pulmonary Disease was recognized as the highest-impact journal. M.A. Spruit and Maastricht University were identified as the most prolific individual author and institution, respectively. However, bibliometric analysis revealed that researcher clusters have not yet reached critical mass, indicating suboptimal interdisciplinary collaboration requiring strategic enhancement. Global research efforts concentrated on 10 thematic clusters: palliative car, chronic obstructive pulmonary disease, mental health, cardiovascular interactions, systemic inflammation, chronic disease, chronic pain, heart failure, pulmonary rehabilitation, chronic obstruction. The field has shifted through three evolutionary phases: clinical phenotyping-molecular mechanism elucidation-systemic intervention frameworks. Future research should prioritize multi-omics integration, digital biomarker discovery, and precision pharmacotherapy. Such advancements will optimize holistic management strategies for chronic obstructive pulmonary disease with comorbid anxiety and depression.

Key words: chronic obstructive pulmonary disease, anxiety, depression, bibliometrics, research hotspots

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