中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (14): 3027-3033.doi: 10.12307/2025.613

• 组织构建综述 tissue construction review • 上一篇    下一篇

脑机接口技术在脑卒中患者下肢功能康复中的应用前景

王  珂1，王  雷2，李文杉3，公维军4   

  1. 1云南中医药大学，云南省昆明市  650000；2杭州程天科技发展有限公司，浙江省杭州市  310000；3首都医科大学，北京市  100000；4首都医科大学附属北京康复医院，北京市  100144
  • 收稿日期:2024-05-16 接受日期:2024-07-15 出版日期:2025-05-18 发布日期:2024-09-29
  • 通讯作者: 公维军，博士，教授，博士生导师，首都医科大学附属北京康复医院，北京市 100144
  • 作者简介:王珂，女，1999年生，山西省晋城市人，汉族，云南中医药大学研究生在读硕士，主要从事神经康复方面的研究。
  • 基金资助:
    国家重点研发计划项目(2023YFC3603800，2023YFC3603803)，子课题负责人：公维军；首都卫生发展专项项目
    (2022-1-2251)，项目负责人：公维军

Application prospect of brain-computer interface technology in the rehabilitation of lower limb function in stroke patients

Wang Ke1, Wang Lei2, Li Wenshan3, Gong Weijun4    

  1. 1Yunnan University of Chinese Medicine, Kunming 650000, Yunnan Province, China; 2Chengtian Technology Co., Ltd., Hangzhou 310000, Zhejiang Province, China; 3Capital Medical University, Beijing 100000, China; 4Beijing Rehabilitation Hospital Affiliated to Capital Medical University, Beijing 100144, China
  • Received:2024-05-16 Accepted:2024-07-15 Online:2025-05-18 Published:2024-09-29
  • Contact: Gong Weijun, MD, Professor, Doctoral supervisor, Beijing Rehabilitation Hospital Affiliated to Capital Medical University, Beijing 100144, China
  • About author:Wang Ke, Master candidate, Yunnan University of Chinese Medicine, Kunming 650000, Yunnan Province, China
  • Supported by:
    National Key R&D Program of China, Nos. 2023YFC3603800 and 2023YFC3603803 (both to GWJ); Capital Health Development Special Project, No. 2022-1-2251 (to GWJ)

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摘要：




文题释义：
脑机接口技术：是通过解码大脑产生的神经生理信号来实现对外部设备控制的技术，即不借助人类的神经肌肉控制系统将大脑中枢系统产生的动作意图通过计算机进行提取和处理，再将此信号转换为命令控制外部设备产生实际动作，使得个体能够实现与外部设备进行直接交互。脑机接口技术的发展为残疾人士提供了一种新的交流和控制方式，同时也为认知神经科学、人机交互和康复医学等领域的研究提供了重要的工具。
脑卒中：又称中风或脑血管意外，是由于脑部血管突然破裂或血管阻塞导致血液不能流入大脑而引起脑组织损伤的急性脑血管疾病。

背景：近年来，脑机接口技术通过对动作意图的识别实现对外部设备的操控，改变了人类与计算机的交互方式，可用于脑卒中后下肢功能的治疗，为脑卒中患者康复带来了新的希望。
目的：分析和总结近些年脑机接口技术在脑卒中患者下肢运动功能康复中的应用，探讨脑机接口技术在脑卒中患者下肢功能康复中的临床应用价值。
方法：以“脑卒中，脑机接口，下肢”为中文检索词，在中国知网进行相关文献检索；以“stroke，brain-computer interfaces，lower extremity”为英文检索词，在PubMed数据库进行相关文献检索，检索时间范围为2014年1月至2024年6月。
结果与结论：脑机接口对脑卒中患者下肢运动功能恢复具有良好的应用前景，在康复医学应用领域正在不断扩大，但其机制尚未完全阐释清楚；此外，在采集患者脑电信号方面存在一定的局限，导致脑机接口系统精确识别肢体运动的能力较差，并且目前该技术的解码方法对识别步态周期存在局限性，不能精确定位到下肢各关节与肌肉的随意运动，阻碍了脑机接口技术的应用。未来的研究应该集中在阐明脑机接口技术对脑卒中患者下肢运动功能恢复的神经机制，增强大脑运动信号提取技术和设备，为个体患者制定多模态反馈实现更有效的运动康复，以期推动脑机接口技术在下肢运动功能康复领域的进一步发展，改善患者的康复效果，提高生活质量。
https://orcid.org/0009-0003-5010-4131(王珂)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 脑卒中, 脑机接口, 下肢, 运动功能, 康复, 综述

Abstract: BACKGROUND: In recent years, brain-computer interface technology has emerged as a transformative approach in human-computer interaction by recognizing movement intentions to control external devices. This technology has been utilized in the treatment of lower limb functions after stroke, offering new hope for the rehabilitation of stroke patients. 
OBJECTIVE: To analyze and summarize the application of brain-computer interface technology in the rehabilitation of lower limb motor functions in stroke patients in recent years, and to explore the clinical application value of brain-computer interface technology in the functional rehabilitation of the lower limbs in stroke patients.
METHODS: a literature search in CNKI and PubMed was conducted using “stroke, brain-computer interfaces, lower extremity” as search terms in Chinese and English, respectively, with the search time range set from January 2014 to June 2024.
RESULTS AND CONCLUSION: Brain-computer interfaces hold promising prospects for the recovery of lower limb motor function in stroke patients, and their application in the field of rehabilitation medicine is continuously expanding. However, the underlying mechanisms have not yet been fully elucidated. Moreover, there are certain limitations in the acquisition of electroencephalogram signals from patients, resulting in reduced precision for brain-computer interface systems in recognizing limb movements. Current decoding methods also exhibit constraints in identifying the gait cycle and fail to accurately locate voluntary movements of the various joints and muscles of the lower limbs, impeding the application of brain-computer interface technology. Subsequent research should focus on elucidating the neural mechanisms by which brain-computer interface technology facilitates the recovery of lower limb motor functions in stroke patients, refining the technologies and devices for extracting brain motor signals, and formulating multimodal feedback for individual patients to realize more effective motor rehabilitation. These advances could propel the development of brain-computer interface technology in the field of lower limb motor function recovery, ameliorate patient rehabilitation outcomes, and elevate the quality of life.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: stroke, brain-computer interface, lower limbs, motor function, rehabilitation, review

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