中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (14): 3020-3026.doi: 10.12307/2025.616

• 组织构建综述 tissue construction review • 上一篇    下一篇

铁死亡与周围神经损伤的关系

吕丽洁1,袁一鸣1,王  艳1,2,裴  飞1,2   

  1. 1黑龙江中医药大学,黑龙江省哈尔滨市  150006;2黑龙江中医药大学附属二院康复医学科,黑龙江省哈尔滨市  150001
  • 收稿日期:2024-05-20 接受日期:2024-07-15 出版日期:2025-05-18 发布日期:2024-09-29
  • 通讯作者: 王艳,教授,黑龙江中医药大学,黑龙江省哈尔滨市 150006;黑龙江中医药大学附属二院康复医学科,黑龙江省哈尔滨市 150001
  • 作者简介:吕丽洁,女,1998年生,河北省保定市人,汉族,黑龙江中医药大学在读硕士,主要从事周围神经损伤修复方面的研究。
  • 基金资助:
    国家自然科学基金面上项目(82274623),项目负责人:王艳;黑龙江中医药大学研究生创新科研项目(2023yjscx005),项目负责人:王艳

Relationship between ferroptosis and peripheral nerve injury

Lyu Lijie1, Yuan Yiming1, Wang Yan1, 2, Pei Fei1, 2    

  1. 1Graduate School, Heilongjiang University of Chinses Medicine, Harbin 150006, Heilongjiang Province, China; 2Department of Rehabilitation Medicine, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, Heilongjiang Province, China 
  • Received:2024-05-20 Accepted:2024-07-15 Online:2025-05-18 Published:2024-09-29
  • Contact: Wang Yan, Professor, Graduate School, Heilongjiang University of Chinses Medicine, Harbin 150006, Heilongjiang Province, China; Department of Rehabilitation Medicine, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, Heilongjiang Province, China​
  • About author:Lyu Lijie, Master candidate, Graduate School, Heilongjiang University of Chinses Medicine, Harbin 150006, Heilongjiang Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 82274623 (to WY); Heilongjiang University of Chinese Medicine Graduate Student Innovative Scientific Research Project, No. 2023yjscx005 (to WY)

摘要:


文题释义:
铁死亡:是一种铁依赖性的,区别于细胞凋亡、细胞坏死、细胞自噬的新型细胞程序性死亡的方式。铁死亡的机制是细胞内铁离子的过度蓄积以及脂质的过度氧化,最终诱导细胞氧化性死亡。
周围神经损伤:周围神经是连接中枢神经系统和外周靶组织器官信号通路的中介结构。周围神经损伤是临床常见病之一,特点是严重的感觉障碍和运动功能障碍。

背景:研究已证实铁死亡与多种神经系统疾病的发生机制密切相关,但铁死亡和周围神经损伤后的病理生理机制有待进一步研究和阐明。 
目的:综述细胞铁死亡在治疗周围神经损伤进程中的相关作用与作用机制。
方法:检索CNKI、PubMed等数据库建库至2024年5月期间铁死亡与周围神经系统损伤的相关文献,检索词为“ferroptosis,Peripheral nerve injury,Antioxidant defense system,Schwann cells,Macrophage,Neuroinflammation,Neuropathic pain”和“铁死亡,周围神经损伤,抗氧化防御系统,施万细胞,巨噬细胞,神经炎症,神经性疼痛”,最终纳入60篇文献进行分析。 
结果与结论:铁死亡的发生与细胞内铁代谢异常、活性氧积累及脂质过氧化密切相关。周围神经损伤后施万细胞和巨噬细胞均发生铁死亡,导致微环境变化,并且进一步诱导神经炎症及神经疼痛等疾病的发生。越来越多的研究表明神经损伤与铁死亡密切相关,抑制铁死亡可以促进周围神经损伤后的组织修复及功能恢复,因此,研究周围神经损伤细胞铁死亡的发生机制及调节有着重要意义。目前对铁死亡与周围神经损伤后的作用和调控研究仍处于起步阶段,需要进行更深入的研究,为促进周围神经损伤后修复提供更多的策略。
https://orcid.org/0009-0003-9356-3872(吕丽洁)

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

关键词: 铁死亡, 周围神经损伤, 抗氧化防御系统, 施万细胞, 巨噬细胞, 神经炎症, 神经性疼痛

Abstract: BACKGROUND: It has been confirmed that ferroptosis is closely related to the mechanism of various nervous diseases. However, the pathological mechanisms of ferroptosis and peripheral nerve injury need to be further studied and clarified.
OBJECTIVE: To review the role and mechanism of ferroptosis in the treatment of peripheral nerve injury.
METHODS: The articles related to ferroptosis and nervous system injuries were searched in CNKI and PubMed databases from database inception to May 2024. The keywords were “ferroptosis, peripheral nerve injury, antioxidant defense system, Schwann cells, macrophage, neuroinflammation, neuropathic pain” in Chinese and English, respectively. Sixty eligible articles were finally included for review. 
RESULTS AND CONCLUSION: The occurrence of ferroptosis is closely related to abnormal intracellular iron metabolism, reactive oxygen species accumulation and lipid peroxidation. Ferroptosis occurs in both Schwann cells and macrophages after peripheral nerve injury, leading to changes in the microenvironment and further inducing diseases such as neuroinflammation and neuropathic pain. Increasing studies have shown that nerve injury is closely related to ferroptosis, and inhibition of ferroptosis can promote tissue repair and functional recovery after peripheral nerve injury. Therefore, it is of great significance to study the mechanism underlying the occurrence and regulation of ferroptosis after peripheral nerve injury. Current research on the role and regulation of ferroptosis after peripheral nerve injury is still in its infancy, and more in-depth studies are needed to provide more strategies to promote repair after peripheral nerve injury. 

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

Key words: ferroptosis, peripheral nerve injury, antioxidant defense system, Schwann cells, macrophage, neuroinflammation, neuropathic pain

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