[1] KEPLER CK, PONNAPPAN RK, TANNOURY CA, et al. The molecular basis of intervertebral disc degeneration. Spine J. 2013; 13(3):318-330.
[2] VERGROESEN PP, KINGMA I, EMANUEL KS, et al. Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthritis Cartilage. 2015;23(7):1057-1070.
[3] CHAN SC, WALSER J, KÄPPELI P, et al. Region specific response of intervertebral disc cells to complex dynamic loading: an organ culture study using a dynamic torsion-compression bioreactor. PLoS One. 2013;8(8): e72489.
[4] IVANOVA JI, BIRNBAUM HG, SCHILLER M, et al. Real-world practice patterns, health-care utilization, and costs in patients with low back pain: the long road to guideline-concordant care. Spine J. 2011;11(7): 622-632.
[5] ISGRO M, BURASCHI R, BARBIERI C, et al. Conservative management of degenerative disorders of the spine. J Neurosurg Sci. 2014;58(2 Suppl 1):73-76.
[6] SIEPE CJ, HEIDER F, WIECHERT K, et al. Mid- to long-term results of total lumbar disc replacement: a prospective analysis with 5- to 10-year follow-up. Spine J. 2014;14(8): 1417-1431.
[7] MILLER SM. Low back pain: pharmacologic management. Prim Care. 2012;39(3):499-510.
[8] ALINI M, ROUGHLEY PJ, ANTONIOU J, et al. A biological approach to treating disc degeneration: not for today, but maybe for tomorrow. Eur Spine J. 2002;11 Suppl 2: S215-220.
[9] HENRIKSSON HB, SVALA E, SKIOLDEBRAND E, et al. Support of concept that migrating progenitor cells from stem cell niches contribute to normal regeneration of the adult mammal intervertebral disc: a descriptive study in the New Zealand white rabbit. Spine (Phila Pa 1976). 2012;37(9): 722-732.
[10] ILLIEN-JÜNGER S, PATTAPPA G, PEROGLIO M, et al. Homing of mesenchymal stem cells in induced degenerative intervertebral discs in a whole organ culture system. Spine (Phila Pa 1976). 2012;37(22): 1865-1873.
[11] SAKAI D, NAKAMURA Y, NAKAI T, et al. Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun. 2012;3:1264.
[12] 冯敏,常思远,徐大千,等.重组人粒细胞巨噬细胞集落刺激因子对脓毒症模型小鼠的治疗作用[J].中国组织工程研究, 2016,20(49):7391-7396.
[13] HAUFE SM, MORK AR. Intradiscal injection of hematopoietic stem cells in an attempt to rejuvenate the intervertebral discs. Stem Cells Dev. 2006;15(1):136-137.
[14] RISBUD MV, GUTTAPALLI A, STOKES DG, et al. Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment. J Cell Biochem. 2006;98(1):152-159.
[15] GOGATE SS, NASSER R, SHAPIRO IM, et al. Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins. Arthritis Rheum. 2011;63(7):1950-1960.
[16] GOU S, SHELERUD R, OXENTENKO S, et al. Intervertebral disc stem cell transplant is associated with increases disc heightVA meta-analysis of animal randomized controlled trials. Phoenix, AZ:American Academy of Pain Medicine’s 30th Annual Meeting, 2014.
[17] NAKAJIMA M, SUZUKI T, HARA T, et al. In vitro differentiation of mouse T cell-derived hybrid cells obtained through cell fusion with embryonic stem cells. Biochem Biophys Res Commun. 2019;513(3): 701-707.
[18] BENDTSEN M, BÜNGER CE, ZOU X, et al. Autologous stem cell therapy maintains vertebral blood flow and contrast diffusion through the endplate in experimental intervertebral disc degeneration. Spine (Phila Pa 1976). 2011;36(6):E373-379.
[19] CHEN J, LEE EJ, JING L, et al. Differentiation of mouse induced pluripotent stem cells (iPSCs) into nucleus pulposus-like cells in vitro. PLoS One. 2013;8(9):e75548.
[20] WANG YT, WU XT, WANG F. Regeneration potential and mechanism of bone marrow mesenchymal stem cell transplantation for treating intervertebral disc degeneration. J Orthop Sci. 2010;15(6):707-719.
[21] WANG H, ZHOU Y, CHU TW, et al. Distinguishing characteristics of stem cells derived from different anatomical regions of human degenerated intervertebral discs. Eur Spine J. 2016;25(9):2691-2704.
[22] CORIC D, PETTINE K, SUMICH A, et al. Prospective study of disc repair with allogeneic chondrocytes presented at the 2012 Joint Spine Section Meeting. J Neurosurg Spine. 2013;18(1):85-95.
[23] MOCHIDA J, SAKAI D, NAKAMURA Y, et al. Intervertebral disc repair with activated nucleus pulposus cell transplantation: a three-year, prospective clinical study of its safety. Eur Cell Mater. 2015;29:202-212.
[24] MEISEL HJ, SIODLA V, GANEY T, et al. Clinical experience in cell-based therapeutics: disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc. Biomol Eng. 2007; 24(1):5-21.
[25] TZAAN WC, CHEN HC. Investigating the possibility of intervertebral disc regeneration induced by granulocyte colony stimulating factor-stimulated stem cells in rats. Adv Orthop. 2011;2011:602089
[26] SAKAI D, NISHIMURA K, TANAKA M, et al. Migration of bone marrow-derived cells for endogenous repair in a new tail-looping disc degeneration model in the mouse: a pilot study. Spine J. 2015;15(6): 1356-1365.
[27] NOMURA T, MOCHIDA J, OKUMA M, et al. Nucleus pulposus allograft retards intervertebral disc degeneration. Clin Orthop Relat Res. 2001; (389):94-101.
[28] MEISEL HJ, GANEY T, HUTTON WC, et al. Clinical experience in cell-based therapeutics: intervention and outcome. Eur Spine J. 2006; 15 Suppl 3:S397-405.
[29] YOSHIKAWA T, UEDA Y, MIYAZAKI K, et al. Disc regeneration therapy using marrow mesenchymal cell transplantation: a report of two case studies. Spine (Phila Pa 1976). 2010;35(11):E475-480.
[30] PETTINE KA, MURPHY MB, SUZUKI RK, et al. Percutaneous injection of autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months. Stem Cells. 2015;33(1):146-156.
[31] ELABD C, CENTENO CJ, SCHULTZ JR, et al. Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study. J Transl Med. 2016;14:253.
[32] MICHALEK AJ, BUCKLEY MR, BONASSAR LJ, et al. The effects of needle puncture injury on microscale shear strain in the intervertebral disc annulus fibrosus. Spine J. 2010;10(12):1098-1105.
[33] SERIGANO K, SAKAI D, HIYAMA A, et al. Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model. J Orthop Res. 2010;28(10):1267-1275.
[34] 孟祥玉,巴穆登,艾尔肯•阿木冬.两种方法建立兔腰椎间盘退变模型[J].中国组织工程研究,2017,21(4):564-568.
[35] PATTAPPA G, PEROGLIO M, SAKAI D, et al. CCL5/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture. Eur Cell Mater. 2014;27:124-136.
[36] GRAD S, BOW C, KARPPINEN J, et al. Systemic blood plasma CCL5 and CXCL6: Potential biomarkers for human lumbar disc degeneration. Eur Cell Mater. 2016;31:1-10.
[37] WANG Z, PEREZ-TERZIC CM, SMITH J, et al. Efficacy of intervertebral disc regeneration with stem cells - a systematic review and meta-analysis of animal controlled trials. Gene. 2015;564(1):1-8.
[38] MALIK KM, COHEN SP, WALEGA DR, et al. Diagnostic criteria and treatment of discogenic pain: a systematic review of recent clinical literature. Spine J. 2013;13(11):1675-1689.
[39] ROBERTS S, EVANS EH, KLETSAS D, et al. Senescence in human intervertebral discs. Eur Spine J. 2006;15 Suppl 3:S312-316.
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