中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (30): 4849-4854.doi: 10.3969/j.issn.2095-4344.0985

• 生物材料综述 biomaterial review • 上一篇    下一篇

人工血管研究现状与应用优势

严 拓1,刘雅文1,吴 灿1,周 峰1,刘思诗1,刘 园1,欧阳晨曦2   

  1. 1武汉杨森生物技术有限公司,湖北省武汉市 430079;2中国医学科学院阜外医院血管外科,北京市 100037
  • 收稿日期:2018-05-29 出版日期:2018-10-28 发布日期:2018-10-28
  • 通讯作者: 欧阳晨曦,副主任医师,中国医学科学院阜外医院血管外科,北京市 100037
  • 作者简介:严拓,男,1984年生,汉族,2010年暨南大学毕业,硕士,主要从事与人工血管相关领域产品的研究与开发工作。
  • 基金资助:

    国家重点研发计划(2017YFC1104100)

Current situation and development progress of vascular grafts

Yan Tuo1, Liu Ya-wen1, Wu Can1, Zhou Feng1, Liu Si-shi1, Liu Yuan1, Ouyang Chen-xi2   

  1. 1Wuhan Yangsen Biotechnology Co., Ltd., Wuhan 430079, Hubei Province, China; 2Department of Vascular Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China
  • Received:2018-05-29 Online:2018-10-28 Published:2018-10-28
  • Contact: Ouyang Chen-xi, Associate chief physician, Department of Vascular Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China
  • About author:Yan Tuo, Master, Wuhan Yangsen Biotechnology Co., Ltd., Wuhan 430079, Hubei Province, China
  • Supported by:

    the National Key Research and Development Plan of China, No. 2017YFC1104100

摘要:

文章快速阅读:

 

文题释义:
人工血管:用来置换血管、在血管间旁路移植或形成分流的假体,人工血管需具备良好的生物相容性、力学性能及顺应性,移植入人体内需具备一定的抗血栓性及较高的远期通畅率,涤纶、聚四氟乙烯、聚氨酯等高分子材料均可用于制备人工血管。
组织工程:一门将生命科学和工程学的原理与技术相结合,发展具有生物活性功能的替代物或移植物,用于修复创伤及重建组织功能的交叉学科,其方法是将血管种子细胞接种于天然或合成材料支架上,进而构建从形态到功能均与活体血管接近的组织工程化血管。
 
 
背景:人工血管特别是小口径人工血管(内径≤4 mm)已成为国内外研究的热点。
目的:综述目前市售的人工血管产品情况,并重点介绍人工血管领域的研究热点和技术方向。
方法:作者以“vascular graft,vascular pro-tissue engineering;人工血管,组织工程”为关键词,检索2000至2018年期间CNKI、Sciencedirect、Web of Science、Springerlink等数据库中的相关文献。初检文章150篇,筛选后对52篇文章进行分析。

结果与结论:目前的人工血管材料主要有动物源脱细胞基质、天然材料与高分子材料。为了进一步改善人工血管的性能与组织相容性,已将生物涂层技术、静电纺丝、组织工程等手段运用于人工血管领域,在抗血栓、抗组织增生、抗炎及提高远期通畅率等方面表现出巨大的优势。

ORCID: 0000-0002-2144-380X(严拓)

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

关键词: 人工血管, 膨体聚四氟乙烯, 聚酯涤纶, 生物涂层技术, 静电纺丝技术, 组织工程, 生物材料

Abstract:

BACKGROUND: As one of the most important therapeutic methods of vascular diseases, vascular grafts, especially small-diameter vascular grafts (inner diameter ≤ 4 mm), have become trends of research.

OBJECTIVE: To review the states of commercial vascular grafts, and further introduce the research hotspot area and new technology development of vascular grafts.
METHODS: A computer retrieval of CNKI, ScienceDirect, Web of Science and Springerlink databases was performed with “vascular graft, vascular pro-tissue engineering” as key words for relevant articles published from 2000 to 2018. Initially, 150 articles were retrieved, and finally 52 articles were included in result analysis.

RESULTS AND CONCLUSION: The commercial vascular grafts are mainly made of animal-derived acellular matrix, natural materials and polymer materials. For improving the clinical performance, new technologies, including bio-coatings, electrospinning and tissue engineering have been explored in the research of vascular grafts, which are considered as big advantages for antithrombus, anti-histogenesis and anti-inflammation as well as increasing long-term patency rate.

 

Key words: Blood Vessel Prosthesis, Biocompatible Materials, Tissue Engineering

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