中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (14): 2266-2273.doi: 10.3969/j.issn.2095-4344.2017.14.022

• 生物材料综述 biomaterial review • 上一篇    下一篇

骨组织工程支架材料在骨缺损修复及3D打印技术中的应用

党  莹1,李  月2,李瑞玉3,吴立萍4,郭雅静5,宋瑞佳1   

  1. 1邢台医学高等专科学校,河北省邢台市   054000;2承德医学院应用心理学系,河北省承德市   067000;3邢台医学高等专科学校第二附属医院,河北省邢台市  054000;4河北医科大学附属邢台市人民医院,河北省邢台市  054001;5山西博爱医院,山西省太原市   030001
  • 收稿日期:2017-03-09 出版日期:2017-05-18 发布日期:2017-06-10
  • 通讯作者: 李瑞玉,教授,主任医师,硕士生导师,邢台医学高等专科学校第二附属医院,河北省邢台市 054000
  • 作者简介:党莹,女,1982年生,河北省定州市人,汉族,2010年河北科技大学信息学院毕业,硕士,讲师,主要从事计算机数据分析及相关软件开发。
  • 基金资助:

    河北省中医药管理局资助项目(2012068)

Three-dimensional printing technology preparation of bone tissue engineering scaffold materials in bone defect repair

Dang Ying1, Li Yue2, Li Rui-yu3, Wu Li-ping4, Guo Ya-jing5, Song Rui-jia1   

  1. 1 Xingtai Medical College, Xingtai 054000, Hebei Province, China; 2 Department of Applied Psychology, Chengde Medical University, Chengde 067000, Hebei Province, China; 3 Second Affiliated Hospital of Xingtai Medical College, Xingtai 054000, Hebei Province, China; 4 Xingtai People’s Hospital of Hebei Medical University, Xingtai 054001, Hebei Province, China; 5Shanxi Boai Hospital, Taiyuan 030001, Shanxi Province, China
  • Received:2017-03-09 Online:2017-05-18 Published:2017-06-10
  • Contact: Li Rui-yu, Professor, Chief physician, Master’s supervisor, Second Affiliated Hospital of Xingtai Medical College, Xingtai 054000, Hebei Province, China
  • About author:Dang Ying, Master, Lecturer, Xingtai Medical College, Xingtai 054000, Hebei Province, China
  • Supported by:

    the Funded Project of Hebei Provincial Administration of Traditional Chinese Medicine, No. 2012068

摘要:

文章快速阅读

 

文题释义:
骨组织工程支架材料
:骨组织工程支架可以负载生物活性物质用于骨诱导和血管形成,应用的骨组织工程支架材料包括聚合物材料,如天然聚合物材料和高分子聚合物材料;生物陶瓷和金属材料也是目前应用最为广泛的组织修复用骨组织工程支架材料。
3D打印技术:是一种新型技术,能将数字信号转化为物理实体。具有快速性和高度柔性的优点,在骨支架制造方面有广泛的应用前景。采用3D打印技术可以实现个性化定制人工骨。


背景:骨组织工程在骨缺损修复方面起着非常重要的作用,可呈递生物活性物质,促进骨组织生长,进而修复骨缺损,其中,支架是骨组织工程的三要素之一,3D打印技术可以实现骨组织修复的个体化治疗,从而个性化定制人工骨。
目的:分析几种常用的骨组织工程支架材料的生物学特性,探讨3D打印技术在骨组织工程支架构建中的应用。
方法:通过检索2005至2016年PubMed和万方数据库有关骨组织工程支架材料和3D打印技术应用的相关文献。以“组织工程支架,骨缺损,高分子材料,陶瓷材料,金属材料,复合材料,3D打印”为中文检索词,“Tissue Engineering Scaffold,bone defects,polymer materials,Bioceramics,Metal Materials,Composite Materials,3D printing”为中文检索词,检索摘要内同时包含上述检索词的文献,排除重复性研究,最终纳入65篇文献进一步分析。
结果与结论:①目前常用的骨组织工程支架材料包括聚合物材料(如天然聚合物材料和高分子聚合物材料)、生物陶瓷和金属材料等,根据材料的特性将不同材料复合可以弥补单一材料的缺点,并制备新型的组织工程支架材料;②用于组织工程骨制作的3D打印技术包括熔融沉积技术、选择性激光烧结技术、低温沉积制造技术等;③3D打印应用于骨组织工程支架构建时,所用的粉末或黏合剂需具备一定的条件,如流动性、稳定性与可湿性等;用于打印的粉末材料可分为人工合成多聚体、天然高分子聚合物、生物陶瓷及它们的混合物;不同粉末材料的粉末各自优缺点不同,且最终成型效果也不尽相同;④3D打印技术制作的骨组织工程支架在力学、结构、个性化方面有其独特的优势,在骨支架制造方面有广泛的应用前景。

ORCID: 0000-0002-5850-4258(党莹)

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

关键词: 生物材料, 骨生物材料, 生物支架材料, 骨组织工程, 骨缺损, 骨组织修复, 3D打印技术, 个性化定制

Abstract:

BACKGROUND: Bone tissue engineering plays a very important role in the repair of bone defects, which can deliver bioactive substances, promote bone tissue growth and repair bone defects. Bone scaffolds act as one of the three elements of bone tissue engineering. Three-dimensional (3D) printing technology can achieve individualized bone tissue repair through customized artificial bone preparation.
OBJECTIVE: To analyze the biological characteristics of several commonly used bone tissue engineering scaffolds and to explore the application of 3D printing technique in the construction of bone tissue engineering scaffolds.
METHODS: The literatures of PubMed and Wanfang database related to bone tissue engineering scaffold materials and 3D printing technology were retrieved from 2005 to 2016. The Keywords were “tissue engineering scaffold, bone defects, polymer materials, bioceramics, metal materials, composite materials, 3D printing” in English and Chinese, respectively, which would appear simultaneously in title and abstract. Repetitive articles were excluded and finally 65 articles were included in result analysis.
RESULTS AND CONCLUSION: The commonly used bone tissue engineering scaffold materials include polymer materials (natural and macromolecule polymeric materials), bioceramics, and metal materials. According to the characteristics of the materials, composite materials made of different materials can compensate for the shortcomings of a single material, and then developed into new tissue engineering scaffold materials. For the tissue engineering bone production, 3D printing technologies include melt deposition technology, selective laser sintering technology, low temperature deposition manufacturing technology, and etc. When the 3D printing technology is used to prepare a bone tissue engineering scaffold, the use of powder or adhesive must have limited conditions, such as flowability, stability and wettability. Powder materials used for 3D printing can be divided into synthetic polymers, natural macromolecules, bioceramics and their mixtures, with different advantages and disadvantages. Ultimately, the bone engineering scaffolds produced by 3D printing technology have unique advantages in mechanics, structure and individuality, and have wide application prospect in the manufacture of bone scaffolds.

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

Key words: Biocompatible Materials, Stents, Metals, Tissue Engineering

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