中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (40): 6455-6459.doi: 10.3969/j.issn.2095-4344.2015.40.011

• 器官移植动物模型 organ transplantation and animal model • 上一篇    下一篇

前列地尔干预肺动脉高压模型大鼠:组织病理及血管结构变化

何峻峰,顾国妹,杨乐梅   

  1. 上海市浦东医院,上海市  201300
  • 出版日期:2015-09-30 发布日期:2015-09-30
  • 通讯作者: 何峻峰,上海市浦东医院,上海市 201300
  • 作者简介:何峻峰,男,1975年生,江西省赣州市人,汉族, 2007年广州医学院毕业,硕士,主治医师,主要从事感染性疾病研究。

Use of alprostadil for the treatment of pulmonary hypertension in rats: variations in histopathology and vessel structure 

He Jun-feng, Gu Guo-mei, Yang Le-mei   

  1. Shanghai Pudong Hospital, Shanghai 201300, China
  • Online:2015-09-30 Published:2015-09-30
  • Contact: He Jun-feng, Master, Attending physician, Shanghai Pudong Hospital, Shanghai 201300, China
  • About author:He Jun-feng, Master, Attending physician, Shanghai Pudong Hospital, Shanghai 201300, China

摘要:

背景:肺动脉高压尚缺乏有效的治疗措施,前列地尔治疗肺动脉高压的效果存在一定的争议。

目的:观察前列地尔治疗慢性缺氧所致的肺动脉高压的效果。

方法:将24只大鼠随机等分成对照组、模型组和治疗组,后2组采用缺氧箱建立大鼠肺动脉高压动物模型,对照组大鼠采用正常空气饲养。建模成功后,治疗组大鼠按5 μg/(kg•d)腹腔注射前列地尔注射液,连续给药4周。

结果与结论:与模型组相比,经前列地尔治疗的肺动脉高压模型大鼠平均肺动脉压和右心室收缩压明显下降,肺血管厚度、血管的大小及肺泡壁厚度明显减小。表明前列地尔可以降低肺动脉压,防止肺损伤。

 中国组织工程研究杂志出版内容重点:肾移植肝移植移植;心脏移植;组织移植;皮肤移植;皮瓣移植;血管移植;器官移植组织工程

关键词: 实验动物, 心肺及血管损伤动物模型, 前列地尔, 肺动脉高压, 肺损伤, 慢性阻塞性肺病, 肺源性心脏病, 肺血管

Abstract:

BACKGROUND: Pulmonary hypertension still lacks effective treatment measures. The effects of alprostadil in the treatment of pulmonary hypertension remain controversial.

OBJECTIVE: To observe the effect of alprostadil in the treatment of pulmonary hypertension induced by chronic hypoxia.

METHODS: 24 experimental rats were randomly and evenly divided into control group, model group, and treatment group. The rats of model and treatment groups were fed in the hypoxic box to establish the animal model of pulmonary hypertension, and the rats of control group were fed in the normal air. After pulmonary hypertension induction, rats from the treatment group were intraperitoneally administered alprostadil injection   (5 μg/kg per day) for 4 consecutive weeks.

RESULTS AND CONCLUSION: Compared with the model group, the mean pulmonary artery pressure, right ventricular systolic pressure, pulmonary vascular thickness, size of blood vessels and alveolar wall thickness of rats in the treatment group were obviously decreased. The results suggest that alprostadil can decrease pulmonary artery pressure and prevent lung injury.

 中国组织工程研究杂志出版内容重点:肾移植肝移植移植;心脏移植;组织移植;皮肤移植;皮瓣移植;血管移植;器官移植组织工程

Key words: Alprostadil;, Pulmonary Hypertension, Pulmonary Medicine, Pulmonary Heart Disease

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