中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (5): 1021-1025.doi: 10.12307/2025.278

• 骨组织构建 bone tissue construction • 上一篇    下一篇

绝经后女性维生素D水平与生殖特点和运动膳食情况的关系

王东阳，杨巧慧，林欣潮   

  1. 北京中医药大学东直门医院，北京市  100010


  • 收稿日期:2024-01-07 接受日期:2024-02-26 出版日期:2025-02-18 发布日期:2024-06-04
  • 通讯作者: 林欣潮，博士，副主任医师，北京中医药大学东直门医院，北京市 100010
  • 作者简介:王东阳，男，1999年生，河北省成安县人，汉族，北京中医药大学在读硕士，主要从事骨质疏松症和肌少症的研究。
  • 基金资助:
    国家中医临床研究基地业务建设科研专项课题(JDZX2015079)，项目负责人：林欣潮

Relationship between vitamin D levels and reproductive characteristics and exercise dietary situation in postmenopausal women 

Wang Dongyang, Yang Qiaohui, Lin Xinchao   

  1. Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100010, China
  • Received:2024-01-07 Accepted:2024-02-26 Online:2025-02-18 Published:2024-06-04
  • Contact: Lin Xinchao, MD, Associate chief physician, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100010, China
  • About author:Wang Dongyang, Master candidate, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100010, China
  • Supported by:

    National Chinese Medicine Clinical Research Base Scientific Research Special Project, No. JDZX2015079 (to LXC)


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摘要：




文题释义：
绝经后骨质疏松症：是原发性骨质疏松症的一种类型。绝经后骨质疏松症主要发生在绝经后女性，由于雌激素水平缺乏导致骨量减少及骨组织结构变化，以骨脆性增加、易于骨折为特征的全身性骨代谢疾病，严重影响老年人的身体健康和生活质量，甚至缩短寿命。
负钙平衡：多发于老年人群，随着年龄的增长，人体各器官功能开始衰退，当吸收的钙不能补偿排泄的钙时，称之为负钙平衡。当身体处于负钙平衡状态的时候，血液里的钙不够，为了维持身体各器官的正常功能，就会动用骨钙来进行补充，长期积累下来，骨钙将越来越少，最终发生骨质疏松。

背景：研究证明绝经后骨质疏松症与女性生殖特点和运动膳食有关，但是鲜有研究证明女性生殖特点及运动膳食是否对绝经后女性维生素D有影响。
目的：探讨北京市绝经后女性维生素D水平与女性生殖特点和运动膳食情况的关系及其影响因素。
方法：选取2017年9月至2018年5月北京市多个城区的17个社区现场问卷调查的727例46-75岁绝经后女性作为研究对象，问卷内容包括受试者的基本信息和月经史、绝经史、妊娠史、运动膳食情况等。采用电化学发光免疫分析仪及其配套试剂测定25-(OH)D水平；使用双能X射线骨密度检测仪测定腰椎(L1-L4、整体)和双髋关节(股骨颈、整体)的骨密度和T值；观察维生素D与生殖特点和运动膳食的相关性，并进行维生素D的影响因素分析。
结果与结论：①维生素D正常组136例(18.7%)，维生素D不足组389例(53.5%)，维生素D缺乏组202例(27.8%)；平均维生素D水平为 (15.60±5.85) ng/mL。②随着维生素D水平的升高，不同部位的骨密度值及T值也随之升高。③维生素D水平与初潮年龄、月经持续天数、绝经阶段、运动情况、饮食类型、饮食偏好均呈正相关(P < 0.05)；与月经周期、绝经年龄、生育次数均呈负相关(P < 0.05)；与初孕年龄、怀孕次数无相关性(P > 0.05)。④多因素有序 Logistic 回归分析结果显示，喝奶制品频率对绝经后女性维生素D值存在正向相关(P < 0.05)，且奶制品是维生素D水平的保护因素。⑤调查结果说明，北京市绝经后女性维生素D水平普遍不足、骨密度值普遍低下，维生素D水平与部分生殖特点、运动膳食情况存在关联，且其中喝奶制品是其保护因素。因此可以通过开展相关骨质疏松的健康教育，对绝经后女性膳食情况进行调整加以干预，增加体内维生素D含量，以期增加骨密度值，减少绝经后骨质疏松患病率。

https://orcid.org/0009-0009-4248-2419(王东阳)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 北京市, 绝经后女性, 维生素D, 生殖特点, 运动膳食, 骨质疏松

Abstract: BACKGROUND: Studies have demonstrated that postmenopausal osteoporosis is related to female reproductive characteristics and exercise diets, but few studies have demonstrated whether female reproductive characteristics and exercise diets have an effect on vitamin D in postmenopausal women.
OBJECTIVE: To investigate the relationship of vitamin D levels with female reproductive characteristics and exercise diets and their influencing factors in postmenopausal women in Beijing.
METHODS: Totally 727 postmenopausal women with an age range of 46-75 years old who received on-site questionnaires in 17 communities of Beijing from September 2017 to May 2018 were selected as the study subjects, and the questionnaires included the subjects’ basic information and history of menstruation, menopause, pregnancy, and exercise diet. An electrochemiluminescence immunoassay analyzer and its auxiliary reagents were used to determine 25-(OH)D levels. Bone mineral density and T values of the lumbar spine (L1-L4, whole) and both hips (femoral neck, whole) were determined using a dual-energy X-ray bone mineral density detector. The correlation of vitamin D with reproductive characteristics and exercise diet was observed, as well as the influencing factors of vitamin D were analyzed. 
RESULTS AND CONCLUSION: There were 136 cases (18.7%) in the vitamin D normal group, 389 cases (53.5%) in the vitamin D insufficient group, and 202 cases (27.8%) in the vitamin D deficient group. The mean vitamin D level was (15.60±5.85) ng/mL. With the increase of vitamin D level, the bone mineral density value and T value of different parts of the body also increased. Vitamin D level was positively correlated with age at menarche, days of menstrual duration, stage of menopause, activity, diet type, and dietary preference (P < 0.05); was negatively correlated with menstrual cycle, age at menopause, and number of childbearing (P < 0.05); and had no correlation with age at first conception and number of pregnancies (P > 0.05). The results of multifactorial ordered Logistic regression analyses showed that there was a positive correlation between the frequency of drinking dairy products and vitamin D level (P < 0.05), and dairy products were a protective factor for vitamin D level. To conclude, vitamin D levels are generally insufficient and bone mineral density values are generally low in postmenopausal women in Beijing. Vitamin D levels are correlated with some reproductive characteristics and exercise diets, and drinking dairy products is a protective factor. Therefore, it is possible to intervene in the dietary situation of postmenopausal women by means of health education about osteoporosis and by increasing vitamin D levels in order to increase bone density values and reduce the prevalence of osteoporosis in the postmenopausal period.

Key words: Beijing, postmenopausal women, vitamin D, reproductive characteristics, exercise diet, osteoporosis

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