中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (29): 6333-6342.doi: 10.12307/2025.790

• 组织构建相关数据分析 Date analysis of organization construction • 上一篇    下一篇

欧洲人饮食偏好与骨关节炎发病风险的关系：人类全基因组关联研究数据分析

庞家慧1，王  博1，2，胡颖璇1，胡紫薇1，吴  文1   

  1. 1南方医科大学珠江医院康复医学科，广东省广州市  510282；2武汉市第一医院康复科，湖北省武汉市  430000

  • 收稿日期:2024-08-06 接受日期:2024-10-18 出版日期:2025-10-18 发布日期:2025-03-10
  • 通讯作者: 吴文，教授，主任医师，博士生导师，南方医科大学珠江医院康复医学科，广东省广州市 510282
  • 作者简介:庞家慧，女，1998年生，广东省茂名市人，汉族，南方医科大学在读硕士，主要从事骨科康复，疼痛康复方面研究。
  • 基金资助:
    国家自然科学基金项目(82172526，82372553)，项目负责人：吴文；广东省基础与应用基础基金面上项目(2023A1515010200)，项目负责人：吴文

Association between dietary preferences and the risk of osteoarthritis in Europeans: analysis of human genome-wide association study data

Pang Jiahui1, Wang Bo1, 2, Hu Yingxuan1, Hu Ziwei1, Wu Wen1   

  1. 1Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China; 2Department of Rehabilitation, Wuhan No. 1 Hospital, Wuhan 430000, Hubei Province, China 
  • Received:2024-08-06 Accepted:2024-10-18 Online:2025-10-18 Published:2025-03-10
  • Contact: Wu Wen, Professor, Chief physician, Doctoral supervisor, Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China
  • About author:Pang Jiahui, Master candidate, Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 82172526, No. 82372553 (to WW); Guangdong Basic and Applied Basic Research Foundation, No. 2023A1515010200 (to WW)

PDF

151

摘要：


文题释义：
骨关节炎：一种病理表现以软骨侵蚀、软骨下骨硬化、滑膜炎及骨赘形成等进行性关节损伤为主的慢性关节疾病。
两样本孟德尔随机化：一种利用人类全基因组关联研究观察性数据推断暴露因素与结局因素间潜在的因果关系的流行病学方法。

背景：有研究表明饮食摄入与骨关节炎之间存在潜在的关联，但食物偏好与骨关节炎间是否存在因果关系仍未可知。国内目前尚未有大规模饮食偏好与骨关节炎全基因组关联研究。
目的：探究欧洲人群饮食偏好与骨关节炎间的因果关联，以期为骨关节炎的预防提供理论依据，同时为国内髋膝关节骨关节炎高危人群识别提供参考数据。
方法：选用人类全基因组关联研究数据中欧洲人群20种饮食偏好遗传统计数据集筛选暴露因素相关工具变量，结局选用骨关节炎遗传统计数据集，排除与混杂因素相关工具变量后，主要采用逆方差加权分析法进行两样本孟德尔随机化因果关联分析，其余4种统计方法作为补充，并对结果进行敏感性检验。
结果与结论：①逆方差加权分析结果显示，喜好烤肉(OR=1.204，95%CI：1.058-1.370，P=0.005)、牛肉(OR=1.167，95%CI：1.034-1.317，P=0.012)、鸡肉(OR=1.399，95%CI：1.119-1.749，P=0.003)、猪排(OR=1.218，95%CI：1.039-1.427，P=0.015)及咖啡(OR=1.133，95%CI：1.037-1.238，P=0.006)是膝髋关节骨关节炎的风险因素；喜好蔬菜(OR=0.893，95%CI：0.827-0.964，P=0.004)和醋(OR=0.897，95%CI：0.812-0.991，P=0.032)是膝髋关节骨关节炎的保护因素；②敏感性分析结果显示，纳入分析的工具变量不存在水平多效性及偏倚，并根据异质性分析结果使用对应的逆方差加权分析效应模型；③此次研究结果在饮食偏好与髋膝关节骨关节炎相关研究中提供了一定的参考价值，但仅纳入来自欧洲人群的人类全基因组关联研究数据，研究结果在其他种族中的有效性仍待检验；且并未进行性别、年龄及其他健康状态分层，研究结果难以完全排除来自人群分层的偏倚，未来仍需更大规模、更细化分类的样本数据开展相关因果关系研究。
https://orcid.org/0000-0002-5576-2999(吴文)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 饮食偏好, 骨关节炎, 欧洲人群, 孟德尔随机化, 全基因组关联研究, 因果关系

Abstract:

BACKGROUND: Some studies have shown a potential relationship between dietary intake and osteoarthritis, but whether there is a causal relationship between food preferences and osteoarthritis is still unknown. There is currently no large-scale genome-wide association study on dietary preferences and osteoarthritis in China.
OBJECTIVE: To explore the causal association between dietary preferences and osteoarthritis in European populations, in order to provide a theoretical basis for the prevention of osteoarthritis and to provide reference data for the identification of high-risk groups for hip and knee osteoarthritis in China.
METHODS: A total of 20 dietary preference genetic statistics datasets were selected to screen for exposure factor-related instrumental variables. The dataset for osteoarthritis was selected for the ending. After exclusion of the instrumental variables related to confounders, the two-sample Mendelian randomized causal association analysis was conducted mainly by inverse variance weighted analysis, and other four statistical methods were used as supplements. Sensitivity test was performed for the results.
RESULTS AND CONCLUSION: (1) The results of the inverse variance weighted analysis showed that preference for barbecue (OR=1.204, 95%CI: 1.058-1.370, P=0.005), beef (OR=1.167, 95%CI: 1.034-1.317, P=0.012), chicken (OR=1.399, 95%CI: 1.119-1.749, P=0.003), pork chops (OR=1.218, 95%CI:1.039-1.427, P=0.015) and coffee (OR=1.133, 95%CI: 1.037-1.238, P=0.006) were risk factors for osteoarthritis of the knee and hip joints, vegetables (OR=0.893, 95%CI: 0.827-0.964, P=0.004), and vinegar (OR=0.897, 95%CI: 0.812-0.991, P=0.032) were protective factors for knee-hip osteoarthritis. (2) The results of the sensitivity analysis showed that the instrumental variables included in the analysis without horizontal pleiotropy and bias, and the corresponding inverse variance weighted analysis of effects model was used according to the results of the heterogeneity analysis. (3) The results of this study provide certain reference value in the research on the relationship between dietary preferences and hip and knee osteoarthritis, but only included human whole genome association study data from European populations, and the validity of the research results in other races remains to be tested. Moreover, no stratification was performed on gender, age and other health status. It is difficult to completely rule out the bias from population stratification in the research results. In the future, larger-scale and more finely classified sample data are still needed to carry out relevant causal relationship research.

Key words: food preference, osteoarthritis, European population, Mendelian randomization, genome-wide association study, causal association

中图分类号: