中国组织工程研究

中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (4): 650-656.doi: 10.3969/j.issn.2095-4344.0105

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    

中国中老年人膝关节骨关节炎患病率的Meta分析

帖小佳1，郑如庚1，赵  梦1，韩亚军2，郭洪亮3，王治洲4，马国驹1   

  1. 1保定市第二中心医院，河北省涿州市  072750；2新疆医科大学第二附属医院，新疆维吾尔自治区乌鲁木齐市  830000；3阜新市中心医院，辽宁省阜新市  123000；4复旦大学附属金山医院，上海市  201508
  • 收稿日期:2017-09-17 出版日期:2018-02-08 发布日期:2018-02-08
  • 通讯作者: 马国驹，主任医师，保定市第二中心医院，河北省涿州市 072750
  • 作者简介:帖小佳，男，1987年生，河北省易县人，汉族，2014年新疆医科大学毕业，硕士，主要从事骨科创伤、脊柱、关节、运动医学的研究。

Prevalence of knee osteoarthritis in the middle-aged and elderly in China:
a Meta-analysis

Tie Xiao-jia1, Zheng Ru-geng1, Zhao Meng1, Han Ya-jun2, Guo Hong-liang3, Wang Zhi-zhou4, Ma Guo-ju1   

  1. 1Baoding Second Central Hospital, Zhuozhou 072750, Hebei Province, China; 2the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China; 3Fuxin Central Hospital, Fuxin 123000, Liaoning Province, China; 4Jinshan Hospital of Fudan University, Shanghai 201508, China
  • Received:2017-09-17 Online:2018-02-08 Published:2018-02-08
  • Contact: Ma Guo-ju, Chief physician, Baoding Second Central Hospital, Zhuozhou 072750, Hebei Province, China
  • About author:Tie Xiao-jia, Master, Baoding Second Central Hospital, Zhuozhou 072750, Hebei Province, China

PDF

559

被引次数

7

摘要：

文题释义：
膝关节：由股骨内外侧髁、胫骨平台以及髌骨构成，是人体最大且构造复杂的关节，损伤概率亦较多的关节，属于滑车关节。
膝骨关节炎：是发生在关节的一种以退行性病理改变为基础的疾病。可分为原发性与继发性。多患于中老年人群，以关节软骨的变性、破坏以及骨质增生为特征，临床特点主要表现为关节疼痛、变形和功能受限。
摘要
背景：中国很多学者对不同地区做过膝关节骨关节炎的流行病学调查，但大样本多中心的随机抽样调查仍相对缺乏，目前的文献仍不能很好地全面描述国内膝关节骨关节炎的总体流行病学趋势。
目的：通过Meta分析了解中国中老年人膝关节骨关节炎的流行状况。
方法：采用Meta分析对2001至2016年发表的有关中国中老年人膝关节骨关节炎流行病学的文献进行归纳和统计学分析。提取资料中40岁以上人群的膝关节骨性关节患病率，并以10岁为1个年龄组段分别进行汇总，采用stata 12.0软件进行分析。
结果与结论：①纳入26篇文献，提取40岁以上人群样本总量42 199人；②中国40岁以上中老年人膝关节骨关节炎总患病率为17.0%(95%CI：16.7%-17.4%)，其中男性12.3%，女性22.2%，男女性之间差异有显著性意义(P < 0.05)，在男性人群、女性人群及总体人群中均呈现随年龄增长患病率增加；③北方地区总体患病率为16.1%(95%CI：15.6%-16.6%)，其中男性12.2%，女性21.4%；南方地区总体患病率为18.0%(95%CI：17.5%-18.5%)，其中男性12.3%，女性23.1%。在男性人群、女性人群及总体人群中南北方之间患病率比较差异均无显著性意义(P > 0.05)；④农村地区总体患病率为23.6%(95%CI：16.7%-30.4%)，其中男性15.4%，女性28.1%；城市地区总体患病率为20.0%(95%CI：16.2%-23.9%)，其中男性13.7%，女性24.3%。在男性人群、女性人群及总体人群中农村及城市之间患病率比较差异均无显著性意义(P > 0.05)；⑤结果表明，中国中老年人膝关节骨关节炎患病率较高，表现为随年龄增长而增高，男女性之间差异相对较大，南北方之间以及城市与农村之间比较无明显差异，应适时开展骨关节炎宣传和相关疾病的防治工作并实施干预措施。

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程
ORCID: 0000-0001-7137-389X(帖小佳)

关键词: 膝关节, 骨关节炎, 中国地区, 中年人, 老年人, 流行病学, 患病率, 组织构建, Meta分析

Abstract:

BACKGROUND: Investigation on epidemiologic features of knee osteoarthritis in many areas of China has been much reported. However, multicenter studies with large samples have been rarely reported. The published papers cannot give a good description about the epidemiologic features of knee osteoarthritis.
OBJECTIVE: To evaluate the epidemiologic features of knee osteoarthritis in the patients aged over 40 years in China.
METHODS: Meta-analysis was used to evaluate the data extracted from papers published 2001-2016 on the epidemiology of knee osteoarthritis in the middle-aged and elderly in China. The prevalence rate of knee osteoarthritis in the patients over 40 years of age was summarized, with every 10 years as group, and then analyzed on Stata 12.0 software.
RESULTS AND CONCLUSION: Twenty-six articles were included, involving 42 199 people aged more than 40 years old. The total prevalence rate of knee osteoarthritis at the age above 40 years old in China was 17.0% (95%CI: 16.7%-17.4%), the prevalence rate was 12.3% in male and 22.2% in female (P < 0.05). Noticeably, the prevalence rate increased with age. The total prevalence rate in northern China was 16.1% (95%CI: 15.6%-16.6%), 12.2% in male and 21.4% in female; the total prevalence in southern China was 18.0% (95%CI: 17.5%-18.5%), 12.3% in male and 23.1% in female. There was no significant difference in the prevalence rate between northern and southern China (P > 0.05). The total prevalence rate in rural China was 23.6% (95%CI: 16.7%-30.4%), with 15.4% in male and 28.1% in female; and the total prevalence in urban China was 20.0% (95%CI: 16.2%-23.9%), with 13.7% in male and 24.3% in female. There was no significant difference in the prevalence rate between rural and urban China (P > 0.05). These results suggest that knee osteoarthritis in China is a common disease, characterized by increased prevalence with age, relatively significant difference between male and female, but no difference between northern and southern China as well as between rural and urban China. It is of great significance to timely propagate and perform interventional strategies for prevention and treatment of knee osteoarthritis in China.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: China, Knee Joint, Osteoarthritis, Meta-Analysis, Tissue Engineering

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