中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (47): 8899-8906.doi: 10.3969/j.issn.2095-4344.2012.47.031

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

组织工程神经支架材料的临床应用

危宏晖，邓施平   

  1. 井冈山大学附属医院，江西省吉安市 343000
  • 收稿日期:2012-04-09 修回日期:2012-09-21 出版日期:2012-11-18 发布日期:2013-03-15
  • 通讯作者: 邓施平，副主任医师，井冈山大学附属医院，江西省吉安市 343000 573890307@qq.com
  • 作者简介:危宏晖★，男，1974年生，江西永丰县人，汉族，2009年贵阳医学院毕业，硕士，主治医师，主要从事脑血管病及神经介入方向研究。

Clinical application of tissue engineering nerve scaffold materials

Wei Hong-hui, Deng Shi-ping   

  1. Affiliated Hospital of Jinggangshan University, Ji'an 343000, Jiangxi Province, China
  • Received:2012-04-09 Revised:2012-09-21 Online:2012-11-18 Published:2013-03-15
  • Contact: Deng Shi-ping, Associate chief physician, Affiliated Hospital of Jinggangshan University, Ji'an 343000, Jiangxi Province, China 573890307@qq.com
  • About author:Wei Hong-hui★, Master, Attending physician, Affiliated Hospital of Jinggangshan University, Ji'an 343000, Jiangxi Province, China

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被引次数

1

摘要：

背景：神经损伤后没有自我修复的能力，因此，神经组织工程支架材料应用于神经修复、促进神经再生成为研究的热点。
目的：分析目前常用的神经组织工程支架材料的应用范围及效果。
方法：分别对胶原、壳聚糖、凝胶以及透明质酸与人工合成材料形成的聚合物用于神经损伤修复进行动物模型分析，应用免疫染色、生化检测等方法观察评估再生神经的结构和生理功能，确定不同神经组织工程支架材料的应用效果。
结果与结论：神经组织工程支架材料胶原、壳聚糖、凝胶、透明质酸以及人工合成材料均可以通过不同的方式用于损伤神经的再生修复，既可以联合细胞进行生物聚合，也可以联合神经片段移植形成损伤神经桥状联接导管，应用于动物模型实验均显示较好的治疗效果。

关键词: 神经组织, 支架材料, 胶原, 壳聚糖, 凝胶, 透明质酸, 赖氨酸, 轴突, 神经干细胞, 损伤修复, 再生, 移植

Abstract:

BACKGROUND: The injured nerve has no self-repair ability, therefore, nerve tissue engineering scaffolds have achieved increasing attention involving nerve repair and promotion of neural regeneration.
OBJECTIVE: To analyze the application and efficacy of the commonly used nerve tissue engineering scaffolds.
METHODS: The polymer materials which were consisted of collagen, chitosan, gelatin, hyaluronic acid and synthetic materials for the repair of nerve injury were explored in animal models. The structure and physiological functions of the regenerated nerve were observed with immunohistochemical staining and biochemical assay. Thus the application prospect of different nerve tissue engineering scaffolds was observed.
RESULTS AND CONCLUSION: Nerve tissue engineering scaffold materials, such as collagen, chitosan, gelatin, hyaluronic acid and synthetic materials, are all effective in the repair process of nerve injury and regeneration through different ways, they can combine with cells for a biological polymerization, also combines with nerve fragment transplantation to form bridge connecting conduit in the injured nerve, obtaining therapeutic effect in animal model experiments.

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