中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (38): 7037-7041.doi: 10.3969/j.issn.2095-4344.2012.38.002

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

磷酸三钙植骨治疗胫骨远端骨缺损后的骨组织变化

李剑勇，殷潇凡，徐 俊   

  1. 上海市闵行区中心医院骨科，上海市 201100
  • 收稿日期:2012-06-15 修回日期:2012-07-04 出版日期:2012-09-16 发布日期:2012-09-16
  • 通讯作者: 殷潇凡，硕士，主任医师，上海市闵行区中心医院骨科，上海市 201100 tomyxf@ 163.com
  • 作者简介:李剑勇，男，1973年生，浙江省镇海市人，汉族，1997年石河子大学医学院毕业，主治医师，主要从事骨科专业临床工作。 nick-0418@ hotmail.com

Bone histological changes after treatment of distal tibial fracture using tricalcium phosphate

Li Jian-yong, Yin Xiao-fan, Xu Jun   

  1. Department of Orthopedics, Shanghai Minhang Center Hosptial, Shanghai 201100, China
  • Received:2012-06-15 Revised:2012-07-04 Online:2012-09-16 Published:2012-09-16
  • Contact: Yin Xiao-fan, Master, Chief physician, Department of Orthopedics, Shanghai Minhang Center Hosptial, Shanghai 201100, China tomyxf@163.com
  • About author:Li Jian-yong, Attending physician, Department of Orthopedics, Shanghai Minhang Center Hosptial, Shanghai 201100, China nick-0418@ hotmail.com

PDF

539

被引次数

13

摘要：

背景：磷酸三钙作为植骨材料已广泛应用于临床，但多数研究属于体外研究、动物模型研究或临床疗效分析。
目的：观察多孔磷酸三钙应用于胫骨远端骨折骨缺损治疗后的骨组织学变化。
方法：对胫腓骨远端骨折患者采取切开复位内固定，部分患者使用磷酸三钙植骨治疗，观察标本的降解。骨折愈合后二次手术取内固定物，并在原植骨区取极少量骨组织标本再次行组织学观察，比较骨细胞的生长情况。
结果与结论：植骨后患者新生骨组织中成骨细胞增生活跃，骨细胞分化成熟，密度增大，骨小梁密度增宽，骨小梁间纤维组织增生伴毛细血管增生。说明应用多孔磷酸三钙填充骨缺损，新骨生成良好，细胞繁殖旺盛，生物相容性较好。

关键词: 胫骨远端骨折, 磷酸三钙, 植骨, 组织学观察, 骨材料, 组织工程

Abstract:

BACKGROUND: Tricalcium phosphate bone as a kind of graft material has been widely used in clinic, but most studies are in vitro studies, animal models research and clinical analysis.
OBJECTIVE: To observe the bone histological changes after the treatment of distal tibial fractures using the porous tricalcium phosphate.
METHODS: Patients with distal fibular fracture were treated by open reduction and internal fixation. Part of the patients underwent bone grafting using the tricalcium phosphate, and the degradation of specimens was observed after treatment. The internal fixator was obtained during the second operation after bone healing, and a small amount of bone samples were obtained from the original bone graft area for the second histological observation and comparison of growth of osteocytes.
RESULTS AND CONCLUSION: Bone samples exhibited active proliferating osteoblasts in new bone tissue, differentiated and mature osteocytes with increased density, trabeculae with increased density, and fibrous tissue with capillary proliferation between trabeculae. Bone defects filled with porous tricalcium phosphate has many advantages, such as the well new bone formation, strong cell proliferation ability and good biocompatibility.

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