中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (26): 4892-4897.doi: 10.3969/j.issn.1673-8225.2012.26.028

• 骨与关节综述 bone and joint review • 上一篇    下一篇

人工关节假体植入后无菌性松动的发病机制

马玉超1，田 京2   

  1. 1南方医科大学第二临床医学院，广东省广州市 510282；
    2南方医科大学附属珠江医院骨科中心，广东省广州市 510282
  • 收稿日期:2011-11-13 修回日期:2011-12-14 出版日期:2012-06-24 发布日期:2013-11-02
  • 通讯作者: 田京，教授，副主任医师，硕士生导师，南方医科大学附属珠江医院骨科中心，广东省广州市 510282 tian_jing6723@yahoo.com.cn
  • 作者简介:马玉超，女，1990年生，山西省忻州市人，汉族，南方医科大学第二临床医学院2008级临床医学本科双语班。 mycbyts@126.com

Pathogenesis of aseptic prosthesis loosening after artificial prosthesis implantation

Ma Yu-chao1, Tian Jing2   

  1. 1Second Clinical Medical College of Southern Medical University, Guangzhou 510282, Guangdong Province, China;
    2Department of Orthopedics Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China
  • Received:2011-11-13 Revised:2011-12-14 Online:2012-06-24 Published:2013-11-02
  • Contact: Tian Jing, Professor, Associate chief physician, Master’s supervisor, Department of Orthopedics Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China tian_jing6723@yahoo.com.cn
  • About author:Ma Yu-chao, Second Clinical Medical College of Southern Medical University, Guangzhou 510282, Guangdong Province, China mycbyts@126.com

PDF

385

被引次数

12

摘要：

背景：对于人工关节无菌性松动的基础和临床研究很多，但其确切机制仍不甚明确。
目的：综述人工关节假体植入后无菌性松动的发病机制。
方法：由第一作者应用计算机检索PubMed和中国期刊全文数据库2006/2011相关文献。在标题、摘要、关键词中以“artificial prosthesis，aseptic loosening”或“人工关节、无菌性松动”为检索词进行检索。共检索到77篇文献，最终纳入符合标准的文献38篇。
结果与结论：无菌性松动已成为人工关节置换后远期失败的主要原因之一。近年来对人工全髋关节置换后翻修病例回顾性分析的统计显示，无菌性松动位于翻修原因第1位。关于人工关节无菌性松动的机制主要分为机械机制、生物机制及其他机制，它们的共同结果是造成骨吸收、骨溶解，最终导致假体松动。随着研究的进一步深入，以及植入方式及假体材料的不断改进，无菌性松动将最终被最小化，使假体使用寿命更长久。

关键词: 无菌性松动, 机制, 假体, 人工关节, 综述文献

Abstract:

BACKGROUND: There are many clinical researches on aseptic loosening of artificial prosthesis, but the exact pathogenesis is still unclear.
OBJECTIVE: To review the pathogenesis of prosthesis aseptic loosening after artificial prosthesis implantation.
METHODS: A computer-based online search of PubMed and CNKI was performed to search related articles published between 2006 and 2011 with the key words of “artificial prosthesis, aseptic loosening” both in English and Chinese. A total of 77 articles were obtained, and finally 38 articles were included.
RESULTS AND CONCLUSION: Aseptic loosening after long-term total hip replacement is one of the main failure reasons. In the recent years, analysis of revision total hip replacement for failed hip arthroplasty showed that aseptic loosening is the chief reason. The mechanism of aseptic loosening mainly includes mechanical mechanisms, biological and other mechanisms. With further research and the improvement of implantation method and prosthetic materials, aseptic loosening will eventually be minimized, so that the service life of prosthesis will be longer.

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