中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (32): 6056-6059.doi: 10.3969/j.issn.1673-8225.2011.32.038

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

皮肤源性前体细胞的生物学特性与临床应用

李宗哲1，李  阳1，宗兆文2，张连阳2   

  1. 1解放军第三军医大学学员旅17队，重庆市  400038
    2解放军第三军医大学大坪医院野战外科研究所全军战创伤中心，创伤、烧伤与复合伤国家重点实验室，重庆市  400042
  • 收稿日期:2010-04-02 修回日期:2011-07-14 出版日期:2011-08-06 发布日期:2011-08-06
  • 通讯作者: 张连阳，教授，主任医师，博士生导师，解放军第三军医大学大坪医院野战外科研究所全军战创伤中心，创伤、烧伤与复合伤国家重点实验室，重庆市 400042 hpzhangly@163.com
  • 作者简介:李宗哲☆，男，1986年生，吉林省吉林市人，朝鲜族，解放军第三军医大学在读博士，主要从事干细胞方面的研究。 Zongzhe00@yahoo.com.cn
  • 基金资助:

    国家重点基础研究发展计划(973计划)资助项目(2011CB964701)；创伤烧伤与复合伤国家重点实验室自主课题资助项目(SKLZZ200817)。

Biological characteristics and clinical application of skin-derived precursor cells

Li Zong-zhe1, Li Yang1, Zong Zhao-wen2, Zhang Lian-yang2   

  1. 1The 17th Team of Students’ Group, Third Military Medical University of Chinese PLA, Chongqing  400038, China
    2State Key Laboratory of Trauma, Burns and Combined Injury, Department of Trauma and Injuries, Institute of Surgical Research, Daping Hospital, Third Military Medical University of Chinese PLA, Chongqing  400042, China
  • Received:2010-04-02 Revised:2011-07-14 Online:2011-08-06 Published:2011-08-06
  • Contact: Zhang Lian-yang, Professor, Chief physician, Doctoral supervisor, State Key Laboratory of Trauma, Burns and Combined Injury, Department of Trauma and Injuries, Institute of Surgical Research, Daping Hospital, Third Military Medical University of Chinese PLA, Chongqing 400042, China hpzhangly@163.com
  • About author:Li Zong-zhe☆, Studying for doctorate, the 17th Team of Students’ Group, Third Military Medical University of Chinese PLA, Chongqing 400038, China Zongzhe00@yahoo.com.cn
  • Supported by:

    Major Project of Chinese National Programs for Fundamental Research and Development (973 Program), No. 2011CB964701*; Automatic Research Fund of State Key Laboratory of Trauma, Burns and Combined Injury, No.SKLZZ200817*

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摘要：

背景：皮肤源性前体细胞是一种神经嵴来源的前体细胞，具有多向分化潜能。
目的：对皮肤源性前体细胞的培养分离、生物学特性以及临床应用前景作一综述。
方法：应用计算机检索PubMed数据库2001-01/2011-01相关文献，以“skin-derived precursor cells，skin-derived precursors，SKPs”为检索词；共检索到文献137篇，最终纳入符合标准的文献36篇。
结果与结论：皮肤源性前体细胞具有来源丰富、易于获取和多向分化的潜能等优点，能够分化为在体内外都有功能的Schwann细胞、骨样细胞和胰岛素样细胞等多种细胞类型。其在多种组织修复和疾病治疗，特别是神经损伤再修复中显示了良好的应用前景。但其研究仍存在一些问题，需要进一步深入研究。

关键词: 皮肤源性前体细胞, 成体干细胞, 细胞培养, 细胞治疗, 综述文献

Abstract:

BACKGROUND: Skin-derived precursor cells (SKPs) are a novel population of neural crest-related precursor cells that can be isolated from embryonic and adult skin, and have multiple differential potential.
OBJECTIVE: To review the cultivation, separation, biological characteristics and application prospects of SKPs.
METHODS: The PubMed database was searched for articles published from January 2001 to January 2011. The keywords were “skin-derived precursor cells, skin-derived precursors, SKPs”. The language of articles was limited to English.
RESULTS AND CONCLUSION: SKPs are rich in source, easily available and multi-potent. SKPs can differentiate into Schwann cells, neuronal cells and even islet-like cells that have in vitro and in vivo function. SKPs have a good prospect as an experimental and therapeutic resource for disease modelling and regenerative medicine. However, there are still many problems in application.

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