中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (26): 4252-4257.doi: 10.3969/j.issn.2095-4344.2017.26.026

• 生物材料综述 biomaterial review • 上一篇    下一篇

葡聚糖作为新型医用敷料的应用研究与前景

王小林1,赵  博2,潘  博1
  

  1. 1中国医学科学院整形外科医院,北京市  100000;2北京博辉瑞进生物科技有限公司,北京市  100000
  • 收稿日期:2017-05-03 出版日期:2017-09-18 发布日期:2017-09-28
  • 通讯作者: 潘博,博士,副主任医师,中国医学科学院整形外科医院,北京市 100000
  • 作者简介:潘博,博士,副主任医师,中国医学科学院整形外科医院,北京市 100000
  • 基金资助:
    国家高技术研究发展计划(863计划)(2015AA033602)

Application and prospect of dextran as a new medical dressing

Wang Xiao-lin1, Zhao Bao2, Pan Bo1
  

  1. 1Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing 100000, China; 2Beijing Bohui Ruijin Biological Technology Limited Company, Beijing 100000, China
  • Received:2017-05-03 Online:2017-09-18 Published:2017-09-28
  • Contact: Pan Bo, M.D., Associate chief physician, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing 100000, China
  • About author:Wang Xiao-lin, Studying for master’s degree, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing 100000, China
  • Supported by:
    the National High-tech Research and Development Program of China (863 Program), No. 2015AA033602

摘要:

文章快速阅读:

 

文题释义:
创伤愈合:指机体遭受外力作用,皮肤等组织出现离断或缺损后的恢复过程,包括各种组织的再生、肉芽组织增生、瘢痕组织形成的复杂组合,表现出各种过程的协同作用。
医用敷料:作为伤口处的覆盖物,在伤口愈合过程中,可以替代受损的皮肤起到暂时性屏障作用,提供有利于创面愈合的环境。医用敷料的使用不仅缩短了创面愈合时间,减少资源的浪费,还显著降低了医疗工作量,满足了患者要求。
 
背景:目前市场上各种新型敷料层出不穷,并呈现多样化、多功能的发展趋势,而尚未有一种敷料能够满足人们对理想创面敷料的需求,这种理想的新敷料仍在探索中。
目的:了解葡聚糖的基本生理功能、自身高分子优势以及与其他高分子、大分子结合的促愈合效果,推进葡聚糖作为新型医用敷料的研究进程。
方法:利用计算机检索CNKI、PubMed、万方医学网、维普数据库从2000年1月到2016年12月的相关文献,中文检索词为“葡聚糖,伤口敷料”,英文检索词为“dressing,dextran,wound healing”。通过文献精读和泛读后得到与葡聚糖和伤口敷料相关的综述类文献以及相关研究文献31篇。
结果与结论:①葡聚糖具有促进伤口愈合、提高免疫力的生理功能,这些生理功能是葡聚糖作为医用敷料的基础;②葡聚糖具有吸水性、生物可降解性、无毒性等高分子优势;③将葡聚糖与其他高分子、大分子结合制备的新型聚合物已通过动物实验发现具有促进伤口愈合的效果。以上几点共同说明了葡聚糖在制备新型医用敷料方面具有广阔的临床前景。

关键词: 生物材料, 材料相容性, 医用敷料, 葡聚糖, 伤口愈合, 研究进展

Abstract:

BACKGROUND: Currently, a variety of new dressings have been on the market, which are diversified and exhibit multifunctional trends. However, ideal wound dressings are still in exploration.
OBJECTIVE: To introduce the basic physiological function and polymer advantage of dextran as well as its effects to promote wound healing in combination with other macromolecule materials, in order to impel the development of dextran as a new medical dressing
METHODS: A computer-based search of CNKI, PubMed, WanFang, VIP databases was performed to retrieve reviews or research articles addressing dextran and medical dressings published from January 2000 to December 2016. The keywords were “dressing, dextran, wound healing” in Chinese and English, respectively. Finally, 31 articles were included in result analysis.
RESULTS AND CONCLUSION: Dextran has the physiological functions of promoting wound healing and immune function. These physiological functions are the basis of dextran as a medical dressing. Additionally, dextran has some polymer advantages, such as water absorption, biodegradability and non-toxicity. It is noteworthy that dextran can be combined with macromolecules to produce new polymer materials that can promote wound healing in animal experiments. Taken together, dextran, as a medical dressing, has a broad clinical prospect in wound healing.

Key words: Biological Dressings, Glucans, Wound Healing, Tissue Engineering

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