中国组织工程研究

中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (2): 316-321.doi: 10.3969/j.issn.2095-4344.2015.02.029

• 组织构建循证医学 evidence-based medicine in tissue construction • 上一篇    下一篇

管状胃与全胃相比较行消化道重建的Meta分析

刘兰波1，齐  海1，郑实谊2   

  1. 1新疆医科大学第二附属医院胸外科，新疆维吾尔自治区乌鲁木齐市  830000；2新疆医科大学第一附属医院胸外科，新疆维吾尔自治区乌鲁木齐市  830000
  • 收稿日期:2014-11-25 出版日期:2015-01-08 发布日期:2015-01-08
  • 通讯作者: 齐海，主任医师，教授，博士生导师，新疆医科大学第二附属医院胸外科，新疆维吾尔自治区乌鲁木齐市 830000
  • 作者简介:刘兰波，男，1987年生，黑龙江省拜泉县人，汉族，新疆医科大学在读硕士，医师，主要从事食管癌治疗的研究。

A Meta-analysis of tubular stomach versus whole stomach for digestive tract reconstruction

Liu Lan-bo1, Qi Hai1, Zheng Shi-yi2   

  1. 1Department of Thoracic Surgery, Second Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China; 2Department of Thoracic Surgery, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
  • Received:2014-11-25 Online:2015-01-08 Published:2015-01-08
  • Contact: Qi Hai, Chief physician, Professor, Doctoral supervisor, Department of Thoracic Surgery, Second Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
  • About author:Liu Lan-bo, Studying for master’s degree, Department of Thoracic Surgery, Second Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China

PDF

742

被引次数

10

摘要：

背景：近10年来国内外学者提出了管状胃替代食管行消化道重建的方法，然而其术后并发症的发生率却一直存在争议。
目的：评价食管癌根治术中管状胃代全胃行消化道重建的临床疗效。
方法：计算机检索PubMed、OVID、CNKI、EBSCO、Science online、万方、超星数字图书馆、中国生物医学文献数据库(CMB)、以及百度和Google搜索引擎，关于食管癌根治术中以管状胃行消化道重建的临床RCT，由两名研究者严格按照纳入标准进行文献筛选，依据Cochrane协助网提供的标准评价文献质量及偏倚风险，采用GRADEprofiler 3.6.1软件评价文献的质量等级，采用Revman5.3软件对数据进行管理和统计分析。
结果与结论：共纳入12篇文献共4 137例患者，合并效应量结果表明管状胃组与全胃组相比较，吻合口瘘发生率、吻合口狭窄发生率两组差异无显著性意义，反流性食管炎发生率及胸胃综合征发生率管状胃组显著少于全胃组。结果表明，管状胃代全胃在食管癌根治术中行消化道重建是一种安全、有效的方法。但是由于纳入的文献仅为英文和中文文献，存在发表偏倚，个别文献样本量较小，尚需大样本高质量的临床RCT试验进一步验证。



中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

关键词: 组织构建, 组织工程, 食管癌根治术, 管状胃, 食管癌, 吻合口瘘, 反流性食管炎, Meta分析

Abstract:

BACKGROUND: Over the past 10 years, scholars have proposed the tubular stomach as an alternative to the whole stomach for digestive tract reconstruction; however, its occurrence rate of postoperative complications has been controversial.
OBJECTIVE: To evaluate the clinical efficacy of tubular stomach versus whole stomach for digestive tract reconstruction in the resection of esophageal carcinoma.
METHODS: The randomized controlled trials about tubular stomach for digestive tract reconstruction in the resection of esophageal carcinoma were searched from PubMed, OVID, CNKI, EBSCO, Science online, Wangfang, Super Star Digital Library, CMB, Baidu and Google search engines. Two searchers screened studies based on the included criteria strictly. Literature quality and bias risk were assessed according to the criteria of Cochrane Collaboration, GRADEprofiler3.6.1 software was used for evaluation of the quality grade, and Revman5.3 for data management and statistical analysis.
RESULTS AND CONCLUSION: Totally 12 randomized controlled trials including 4 137 patients were enrolled. Compared with the whole stomach group, in the tubular stomach group, the incidences of reflux esophagitis and thoracic stomach syndrome were significantly lower, but there was no difference in the incidences of anastomotic leakage and anastomotic stenosis between the two groups. These findings indicate that the tubular stomach as a substitute of the whole stomach for digestive tract reconstruction in the resection of esophageal carcinoma is a safe and effective. However, the literatures included are only in English and Chinese, and there is publication bias and small sample size. Therefore, the large-sample high-quality clinical randomized controlled trials are still needed for further confirmation.



中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

Key words: Esophageal Neoplasms, Anastomotic Leak, Esophagitis, Peptic

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