中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (34): 6421-6430.doi: 10.3969/j.issn.2095-4344.2012.34.030

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

生物材料修复颅骨缺损：10年国际出版文献分析

谭立宇   

  1. 井冈山大学附属医院神经外科， 江西省吉安市 343000
  • 收稿日期:2012-02-08 修回日期:2012-07-20 出版日期:2012-08-19 发布日期:2012-08-19
  • 作者简介:谭立宇，男，1971年生，江西省吉安市人，汉族，1992年江西医学院毕业，副主任医师，主要从事颅脑损伤方面的研究。 tanly@163.com

The 10-year literature analysis of biological materials to repair skull defects

Tan Li-yu   

  1. Department of Neurosurgery, Affiliated Hospital of Jinggangshan University, Ji’an 343000, Jiangxi Province, China
  • Received:2012-02-08 Revised:2012-07-20 Online:2012-08-19 Published:2012-08-19
  • About author:Tan Li-yu, Associate chief physician, Department of Neurosurgery, Affiliated Hospital of Jinggangshan University, Ji’an 343000, Jiangxi Province, China tanly@163.com

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摘要：

背景：随着技术的发展，不同种类颅骨修补材料性能及临床应用效果不尽相同，很多修补材料因自身的种种缺点已经被淘汰，新型的生物材料仍在进一步开发。
目的：探讨颅骨修补材料的研究进展及数据分析结果。
方法：SCI数据库中2002/2011检索有关生物材修复颅骨缺损文献，检索词为“颅骨缺损(skull defect)；修补(repair)；复合材料(material)；钛网(titanium plate)；骨水泥(bone cement)；自体骨(autogenous bone) ；硅橡胶(silicone rubber)；有机玻璃(organic glass or "pmma" or polymethyl methacrylate)”，共检索文献242篇。
结果与结论：颅骨缺损的修复材料甚多，疗效不一，目前主要有自体骨、异体骨、医用高分子材料、钛金属材料、骨水泥以及组织工程复合材料等，采用何种修补材料能将颅骨缺损修复的更加完美是当前国内外学者研究的热点。

关键词: 颅骨缺损, 修补, 复合材料, 钛网, 骨水泥, 自体骨, 硅橡胶, 有机玻璃, 文献计量

Abstract:

BACKGROUND: With technology developing, the properties and clinical effects of various cranioplasty materials are different. Many repairing materials have been eliminated because of their own shortcomings, and the new types of biological materials are still under development.
OBJECTIVE: To explore the progress of cranioplasty materials and to analyze the data results.
METHODS: A retrieval was performed for the literature about biological materials to repair skull defects, published between 2002-01 and 2011-12, using key words of skull defect, repair, material, titanium plate, bone cement, autogenous bone, silicone rubber, organic glass or pmma or polymethyl methacrylate in Science Citation Index (SCI) database.
RESULTS AND CONCLUSION: The repairing materials are various with different effects on skull defect repair. Now, the materials mainly include the autologous bone, allograft bone, medical polymer materials, titanium, bone cement and tissue engineering composites. The focus is what kind of materials can repair skull defects perfectly.

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