中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (25): 4659-4662.doi: 10.3969/j.issn.1673-8225.2012.25.020

• 药物控释材料 drug delivery materials • 上一篇    下一篇

榄香烯透皮凝胶的制备及体外透皮性能

刘星言1，刘 宏1，范海珠2，林 晶2，曾昭武1，何志巍1   

  1. 1广东医学院，广东省东莞市523808；
    2杭州师范大学，浙江省杭州市 310012
  • 收稿日期:2011-12-20 修回日期:2012-03-22 出版日期:2012-06-17 发布日期:2013-11-04
  • 通讯作者: 林晶，助理研究员，杭州师范大学，浙江省杭州市 310012 linjing1982@ 163.com 曾昭武，副研究员，广东医学院，广东省东莞市 523808 artgreenking@ 126.com 何志巍，广东医学院，广东省东莞市523808
  • 作者简介:刘星言☆，女，1977年生，湖南省湘潭市人，汉族，2009年中南大学毕业，博士，现任广东医学院中美肿瘤研究所副研究员，主要从事纳米医药的研究。 lxy0428@ 126.com
  • 基金资助:

    国家青年自然基金项目(81001647)；广东省自然科学基金项目(9151051501000035)；浙江省科技厅资助项目(2009C33005)；中国博士后科学基金面上项目(20100471757)

Preparation of elemene transdermal gel and its skin penetration in vitro

Liu Xing-yan1, Liu Hong1, Fan Hai-zhu2, Lin Jing2, Zeng Zhao-wu1, He Zhi-wei1   

  1. 1Guangdong Medical College, Dongguan 523808, Guangdong Province, China;
    2Hangzhou Normal University, Hangzhou 310012, Zhejiang Province, China
  • Received:2011-12-20 Revised:2012-03-22 Online:2012-06-17 Published:2013-11-04
  • Contact: Lin Jing, Assistant investigator, Hangzhou Normal University, Hangzhou 310012, Zhejiang Province, China Zeng Zhao-wu, Associate investigator, Guangdong Medical College, Dongguan 523808, Guangdong Province, China He Zhi-wei, Guangdong Medical College, Dongguan 523808, Guangdong Province, China
  • About author:Liu Xing-yan☆, Doctor, Associate investigator, Guangdong Medical College, Dongguan 523808, Guangdong Province, China lxy0428@126.com

PDF

600

被引次数

3

摘要：

背景：选择合适的载体材料对药物透皮性能的影响是制备榄香烯透皮制剂首先要解决的问题。
目的：建立一种榄香烯透皮凝胶并观察其体外透皮性能。
方法：采用具有良好生物相容性的亲水性高分子材料聚乙烯醇和羧甲基纤维素钠制备榄香烯透皮制剂。在体外透皮实验装置上，用鼠背皮肤为屏障进行经皮渗透实验，高效气相色谱检测榄香烯的经皮渗透量。
结果与结论：聚乙烯醇和羧甲基纤维素钠的使用比例对榄香烯的透皮能力没有显著影响；两种高分子骨架材料在凝胶基质中的浓度对榄香烯透皮能力有一定的影响，以30%含量(聚乙烯醇与羧甲基纤维素钠总量)为最佳。提示此种透皮凝胶可用作榄香烯的良好载体。

关键词: 榄香烯, 透皮, 基质, 凝胶, 性能, 生物材料

Abstract:

BACKGROUND: Effect of choosing a suitable carrier material on elemene transdermal properties is the problem of elemene transdermal preparation and need to be resolved first.
OBJECTIVE: To prepare an elemene transdermal gel and to investigate its skin penetration in vitro.
METHODS: An elemene transdermal gel was prepared by using hydrophilic polymer polyvinyl alcohol and sodium carboxymethyl cellulose each with good biocompatibility. In the experimental installation for skin penetration in vitro, the mouse dorsal skin was isolated as a barrier for percutaneous penetration experiments. Percutaneous infiltration quantity of elemene was detected by high resolution gas chromatography.
RESULTS AND CONCLUSION: The ratio of polyvinyl alcohol and scarboxymethyl cellulose showed no significant effect on the transdermal ability of elemene. But their concentration in the gel matrix had a certain influence on the transdermal ability of elemene, and 30% content (total content of polyvinyl alcohol and sodium carboxymethyl cellulose) was optimal. These findings suggest that this kind of transdermal gel can be used as a good carrier for elemene.

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