中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (21): 3933-3935.doi: 10.3969/j.issn.1673-8225.2012.21.031

• 生物材料基础实验 basic experiments of biomaterials • 上一篇    下一篇

口服榄香烯微乳的制备与表征***☆

刘星言1，曾昭武1，刘  宏1，周广林2，丁元林1   

  1. 1广东医学院，广东省东莞市  523808；2杭州师范大学，浙江省杭州市  310012
  • 收稿日期:2011-11-20 修回日期:2012-02-22 出版日期:2012-05-20 发布日期:2012-05-20
  • 通讯作者: 丁元林，博士，教授，广东医学院，广东省东莞市 523808 artgreenking@126.com
  • 作者简介:刘星言☆，女，1977年生，湖南省湘潭市人，汉族，博士，助理研究员，主要从事纳米医药研究工作。lxy0428@126.com
  • 基金资助:

    国家青年自然基金项目(81001647)；广东省自然科学基金项目(9151051501000035)；中国博士后科学基金面上项目(20100471757)。

Preparation and characterization of an oral microemulsion of elemene

Liu Xing-yan1, Zeng Zhao-wu1, Liu Hong1, Zhou Guang-lin2, Ding Yuan-lin1   

  1. 1Guangdong Medical College, Dongguan  523808, Guangdong Province, China; 2Hangzhou Normal University, Hangzhou  310012, Zhejiang Province, China
  • Received:2011-11-20 Revised:2012-02-22 Online:2012-05-20 Published:2012-05-20
  • Contact: Ding Yuan-lin, Doctor, Professor, Guangdong Medical College, Dongguan 523808, Guangdong Province, China artgreenking@126.com
  • About author:Liu Xing-yan☆, Doctor, Assistant investigator, Guangdong Medical College, Dongguan 523808, Guangdong Province, China lxy0428@126.com
  • Supported by:

    National Natural Science Foundation for the Youth, No.81001647*; Natural Science Foundation of Guangdong Province, No.9151051501000035*; China Postdoctoral Science Foundation, No. 20100471757*

PDF

338

被引次数

7

摘要：

背景：研究显示，微乳可保护稳定性差的药物，增加难溶性药物的溶解度，提高生物利用度，控制药物释放及减少用药个体差异等。其主要缺点在于需要较多的表面活性剂和助表面活性剂，对人体的安全性是一个重要挑战。
目的：探讨榄香烯微乳的制备方法，并对其结构与性能进行表征。
方法：榄香烯药物直接作为油相，吐温80作为表面活性剂，乙醇、丙二醇、甘油作为助表面活性剂，采用超声法制备成榄香烯微乳。
结果与结论：榄香烯微乳粒径为(67±13) nm，Zeta电位为(3.2±0.4) mV，pH值为5.16，黏度为6 mPa•s，表面张力为      31.7 mN/m。榄香烯微乳中β-榄香烯含量为(8.273±0.018) g/L，平均包封率为(99.81±0.24)%。结果可见该方法制备的榄香烯微乳粒径小，分布窄，呈弱酸性，黏度低，表面张力较低，体系稳定性好，适用于口服给药。

关键词: 榄香烯, 微乳, 口服, 制备, 表征

Abstract:

BACKGROUND: Several studies have shown that microemulsion can protect the drugs with poor stability and increase the solubility of water-insoluble drugs, as well as improve the biological availability. Furthermore, it can control drug release and reduce the individual differences in drug administration. However, it needs more surfactants and cosurfactants, and it is a challenge for human safety. 
OBJECTIVE: To investigate the preparation of an elemene microemulsion and characterize its structures and properties.
METHODS: Elemene was used as the oil phase and polysorbate 80 (Tween 80) was used as a surfactant. Besides, ethanol, propylene glycol and glycerol were used as cosurfactants. The elemene microemulsion was prepared by ultrasonication method in an ultrasonic bath.
RESULTS AND CONCLUSION: The elemene microemulsion was characterized as a particle size of (67±13) nm, a zeta potential of (3.2±0.4) mv, a pH value of 5.16, a viscosity of 6 mPa•s and a surface tension of 31.7 mN/m. β-elemene content in the elemene microemulsion was (8.273±0.018) mg/mL and its average entrapment efficiency was (99.81±0.24)%. These findings suggest that the elemene microemulsion prepared by this method is characterized by small particle size, narrow distribution, week acid, low viscosity, lower surface tension and good system stability. It is applicable to oral administration.

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