中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (21): 3919-3923.doi: 10.3969/j.issn.1673-8225.2012.21.028

• 药物控释材料 drug delivery materials • 上一篇    下一篇

聚乙烯醇/丙烯酰胺接枝共聚物水凝胶的制备及表征★

史林峰   

  1. 四川大学望江校区高分子学院，四川省成都市  610064
  • 收稿日期:2012-02-23 修回日期:2012-03-14 出版日期:2012-05-20 发布日期:2012-05-20
  • 作者简介:史林峰★，男，1987年生，河南省周口市人，汉族，四川大学在读硕士，主要从事生物医用高分子材料研究。shijiazhijuechang@163.com

Preparation and characterization of poly(vinyl alcohol-g-acrylamide) hydrogel

Shi Lin-feng   

  1. School of Polymer, Wangjiang Campus of Sichuan University, Chengdu  610064, Sichuan Province, China
  • Received:2012-02-23 Revised:2012-03-14 Online:2012-05-20 Published:2012-05-20
  • About author:Shi Lin-feng★, Studying for master’s degree, School of Polymer, Wangjiang Campus of Sichuan University, Chengdu 610064, Sichuan Province, China shijiazhijuechang@163.com

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913

被引次数

6

摘要：

背景：交联水凝胶主要是使大分子链形成网状结构，网固交联基质，这样所得的水凝胶力学性能和透明性相对较差。
目的：采用自由基聚合机制制备聚乙烯醇/丙烯酰胺接枝共聚物水凝胶。
方法：以聚乙烯醇分子作为主链，聚乙烯醇分子中羟基为接枝点，共价接入丙烯酰胺单体。考察反应温度、时间、单体用量和引发剂用量对产物接枝率的影响，通过红外光谱表征聚乙烯醇/丙烯酰胺接枝共聚物共聚物的化学结构。
结果与结论：接枝聚合反应最佳反应条件：引发剂浓度0.04 mol/L、丙烯酰胺/聚乙烯醇(侧羟基)摩尔比6∶1、在40 ℃条件下反应4 h。经过FTIR分析，确认丙烯酰胺与聚乙烯醇发生了聚合反应；经过平衡溶胀测试，分析了接枝聚合物与聚乙烯醇的溶胀率随温度的变化关系，进一步证实了接枝聚合反应的发生，验证了接枝聚乙烯醇/丙烯酰胺接枝共聚物具有明显的温敏性能。
 

关键词: 聚乙烯醇, 丙烯酰胺, 共聚物, 温敏性, 水凝胶

Abstract:

BACKGROUND: Cross-linking gels are prepared by interpenetrating networking, which are formed by polymeric chains. But hydrogel, got in this way, cannot be good at their properties of physics and transmittance.
OBJECTIVE: To prepare poly(vinyl alcohol-g-acrylamide) hydrogel (PVA-g-PAM) via radical copolymerization.
METHODS: We carried out the graft polymerization of acryl amide (AM) onto poly(vinyl alcohol) (PVA), which was to be the backbone. Factors affecting the grafting yield, such as temperature, time, monomer ratio, and initiator dose, were investigated. The chemical structure of grafted copolymers was verified with Fourier transform infrared spectroscopy (FTIR).
RESULTS AND DISCUSSION: We got the way, most efficient, according to the graft copolymerization: the initiator concentration was 0.04 mol/L, ratio of AM/PVA (hydroxyl) was 6/1, temperature was 40 ℃, and reaction time was 4 hours. It was confirmed that the copolymerization of PVA and AM happened by FTIR; and the PVA-g-PAM hydrogel exhibited obvious thermal sensitivity, which was observed from the swelling ratio.

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