中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (53): 10052-10055.doi: 10.3969/j.issn.1673-8225.2011.53.042

• 器官移植循证医学 evidence-based medicine of organ transplantation • 上一篇    下一篇

Meek皮肤移植修复烧伤创面效果与临床应用价值的Meta分析

张宪发，梁自乾，赵学凯，丁华荣   

  1. 广西医科大学第一附属医院烧伤整形外科，广西壮族自治区南宁市  530021
  • 收稿日期:2011-07-18 修回日期:2011-07-25 出版日期:2011-12-31 发布日期:2011-12-31
  • 通讯作者: 梁自乾，教授，硕士生导师，广西医科大学第一附属医院烧伤整形外科，广西壮族自治区南宁市 530021 Liangzqian@yahoo.com.cn
  • 作者简介:张宪发★，男，1983年生，山东省汶上县人，汉族，广西医科大学在读硕士，主要从事创伤修复重建和循证医学方面的研究。 zxianfa2003@163.com
  • 基金资助:

    广西研究生教育创新计划基金(2010105981002M187)。

Effectiveness and clinical value of Meek technique for the repair of burn wounds: A Meta-analysis

Zhang Xian-fa, Liang Zi-qian, Zhao Xue-kai, Ding Hua-rong   

  1. Department of Burn and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-07-18 Revised:2011-07-25 Online:2011-12-31 Published:2011-12-31
  • Contact: Liang Zi-qian, Professor, Master’s supervisor, Department of Burn and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China Liangzqian@yahoo.com.cn
  • About author:Zhang Xian-fa★, Studying for master’s degree, Department of Burn and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China zxianfa2003@163.com
  • Supported by:

    the Innovation Program Foundation for Guangxi Postgraduate Education, No. 2010105981002M187*

PDF

478

被引次数

4

摘要：

背景：近年来关于应用Meek植皮修复烧伤创面有较多临床报道，但就其与传统植皮法相比是否更具优势仍存在争议，且临床研究报道多为小样本对照研究，缺乏说服力。
目的：对Meek植皮修复烧伤创面的疗效及临床应用价值进行系统评价。
方法：计算机检索Cochrane协作网数据库(2009年第12期)、PubMed(1990/2010-12)、Ovid数据库(1966/2011-03)，中国生物医学文献数据库(CBM，1979/2010)、万方数据库(1982/2011)和清华同方数据库(CNKI，1979/2010)，收集有关Meek植皮法修复烧伤创面的临床对照实验(CCT)。评价纳入研究的方法学质量并进行资料提取后，采用RevMan 5.1软件进行Meta分析。
结果与结论：共纳入10个临床对照实验，包括198例大面积烧伤患者。相比于对照组，Meek植皮组创面愈合时间、皮片融合时间、手术操作时间、手术操作人数和1%总烧伤面积的治疗费用均明显减少，提示Meek植皮与传统植皮方法相比能明显促进烧伤创面的愈合，并且能减少医疗花费，简化手术操作，具有明显的临床应用价值。

关键词: 烧伤创面, Meek植皮, 修复, 效果, Meta分析

Abstract:

BACKGROUND: There are many clinical reports on Meek technique for the treatment of major burn injuries. However, the advantages of Meek micrografting technique are still controversial compared with traditional skin graft methods. And most of the controlled clinical trials are performed in small sample size. Therefore the results are lack of convincing.
OBJECTIVE: To assess the effectiveness and clinical value of Meek technique in the treatment of severe burn wounds.
METHODS: An online search of Cochrane Library (2009, No.12), PubMed (1990/2010-12), Ovid Data (1966/2011-03), CBM (1979/2010), Wanfang Data (1982/2011) and CNKI (1979/2010) was performed for controlled clinical trials of Meek technique in the treatment of burn wounds. The data was analyzed using the RevMan 5.1 software after quality evaluation of methodology used in retained articles and data extraction.
RESUITS AND CONCLUSION: A total of 10 controlled clinical trials involving 198 cases of severe burn patients were included. Compared with the control group, the wound healing time, skin graft integration time, operation time, number of operators, and the treatment expenses (1% total body surface area, TBSA) of Meek micrografting technique group were reduced significantly. It suggests that compared with traditional skin graft methods, Meek technique can significantly promote the burn wounds healing, reduce medical costs, shorten surgical operation and have high clinical application value.

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