中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (50): 9477-9480.doi: 10.3969/j.issn.1673-8225.2011.50.041

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

肌肉组织工程研究现状及对运动性肌肉损伤的作用

王鹏举   

  1. 上海工程技术大学体育部，上海市  201620
  • 收稿日期:2011-06-10 修回日期:2011-10-10 出版日期:2011-12-10 发布日期:2011-12-10
  • 作者简介:王鹏举★，男，1974年生，上海市人，汉族，2010年华东师范大学体育学院毕业，硕士，讲师，主要从事体育教育训练学研究。 caokneelift@139.com

Research status and effect of muscle tissue engineering on exercise-induced muscle injury

Wang Peng-ju   

  1. Department of Sports, Shanghai University of Engineering Science, Shanghai  201620, China
  • Received:2011-06-10 Revised:2011-10-10 Online:2011-12-10 Published:2011-12-10
  • About author:Wang Peng-ju★, Master, Lecturer, Department of Sports, Shanghai University of Engineering Science, Shanghai 201620, China caokneelift@139.com

PDF

454

被引次数

2

摘要：

背景：高水平快节奏的体育运动比赛中容易造成肌肉运动损伤，肌肉组织工程为其修复带来希望。
目的：综述肌肉组织工程研究的现状，为运动性肌肉损伤组织工程学研究提供理论基础。
方法：以“tissue engineering, anterior cruciate ligament repair, biological material scaffold, cytokines, seed cells”为关键词，采用计算机检索Pubmed数据库中1994-01/2010-12的相关文章。纳入与运动性肌肉损伤及肌肉组织工程相关的文章；排除重复研究或Meta分析类文章。
结果与结论：共纳入15篇文献，目前的研究重点包括肌肉组织工程重建、细胞外基质复合材料、肌肉组织工程种子细胞的来源、基质支架4个方面。目前的研究表明肌肉组织工程对运动性肌肉损伤的治疗有良好的应用前景。但在实际应用中，肌肉组织工程的种子细胞的选择、支架材料的构建、细胞外基质复合材料研究和组织的相容性等仍是肌肉组织工程学方面的难点问题。

关键词: 生物支架材料, 细胞因子, 种子细胞, 细胞外基质, 运动性肌肉损伤, 肌肉组织工程

Abstract:

BACKGROUND: High levels of fast-paced sports game is likely to cause muscle damage which is hopeful to repair because of muscle tissue engineering.
OBJECTICE: To review the research status of muscle tissue engineering for tissue engineering exercise-induced muscle injury studies provide a theoretical basis.
METHODS: The articles from PubMed database between January 1994 and December 2010 were retrieved by computer with the key words of “tissue engineering, anterior cruciate ligament repair, biological material scaffold, cytokines, seed cells.” Articles related to exercise-induced muscle damage and muscle tissue engineering were included. Meta-analysis an duplicate studies were excluded.
RESULTS AND CONCLUSION: A total of 15 literatures were included. Current researches projects in four areas include rebuilding muscle tissue, extracellular matrix composite materials, muscle tissue engineering seed cells sources, matrix scaffold. Current researches show that exercise-induced muscle tissue engineering for the treatment of muscle injuries has a good prospect. However, in practice applications, muscle tissue-engineered seed cells selection, scaffold construction, extracellular matrix composite materials research and organizational compatibility are the still the difficult problems of muscle tissue engineering.

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