中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (50): 9410-9414.doi: 10.3969/j.issn.1673-8225.2011.50.025

• 组织构建与中医药 tissue construction and traditional Chinese medicine • 上一篇    下一篇

电针抑制骨性关节炎的炎症反应及延缓关节软骨退变

吴明霞1，李西海2，吴广文2，李  俐1，陈文列3，刘献祥2   

  1. 1福建中医药大学附属第二人民医院针灸科，福建省福州市 350003
    2福建中医药大学中西医结合研究院，福建省福州市  350003
    3福建省中西医结合老年性疾病重点实验室，福建省福州市 350108
  • 收稿日期:2011-07-05 修回日期:2011-10-12 出版日期:2011-12-10 发布日期:2011-12-10
  • 通讯作者: 刘献祥，博士，教授，福建中医药大学中西医结合研究院，福建省福州市 350003
  • 作者简介:吴明霞☆，女，1965年生，福建省福州市人，汉族，2010年福建中医药大学毕业，博士，主任医师，教授，主要从事中西医结合防治骨性关节炎的工作。 wumingxiafz@163.com
  • 基金资助:

    上海市科学技术委员会科研项目(08DZ1973200),上海市卫生局中医药科研基金课题(2008L010A)。

Electro-acupuncture treatment inhibits inflammatory reaction and postpones articular cartilage degeneration in osteoarthritis

Wu Ming-xia1, Li Xi-hai2, Wu Guang-wen2, Li Li1, Chen Wen-lie3, Liu Xian-xiang2   

  1. 1Department of Acupuncture and Moxibustion, Second Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350003, Fujian Province, China
    2Fujian Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350003, Fujian Province, China
    3Fujian Integrative Medicine Key Laboratory of Senile Disease, Fuzhou 350108, Fujian Province, China
  • Received:2011-07-05 Revised:2011-10-12 Online:2011-12-10 Published:2011-12-10
  • Contact: Liu Xian-xiang, Doctor, Professor, Fujian Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350003, Fujian Province, China liuxianxiang@163.com
  • About author:Wu Ming-xia☆, Doctor, Chief physician, Professor, Department of Acupuncture and Moxibustion, Second Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350003, Fujian Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 30873277*; Chen Ke-ji Integrative Medicine Development Foundation, No. CKJ2008003* 

PDF

467

被引次数

13

摘要：

背景：研究表明基质金属蛋白酶3在关节软骨退变和破坏中有重要意义。
目的：观察长针透刺与透明质酸钠治疗大鼠膝骨关节炎后，大鼠化膜组织中基质金属蛋白酶3含量变化。
方法：SD大鼠通过膝关节腔内注射1.6%木瓜蛋白酶溶液并驱赶大鼠活动建立膝骨关节炎模型。造模2周后随机分为3组，长针透刺组用直径0.30 mm、长125 mm规格的毫针透刺大鼠犊鼻穴和膝眼穴；药物治疗组关节腔内注射透明质酸钠；模型组不干预。并设立不造模的正常组。
结果与结论：治疗4周后，模型组大鼠滑膜组织基质金属蛋白酶3含量较正常组显著升高(P < 0.05)，长针透刺组、药物治疗组基质金属蛋白酶3含量较模型组显著降低(P < 0.05)，长针透刺组与药物组相近(P > 0.05)。证实长针透刺疗法能有效纠正膝骨关节炎模型大鼠化膜组织中基质金属蛋白酶3的异常表达，这也可能是长针透刺治疗膝骨关节炎的作用原理之一。

关键词: 骨性关节炎, 电针, 细胞因子, 关节软骨, 退变, 骨组织构建

Abstract:

BACKGROUND: Several studies have shown that electro-acupuncture (EA) can effectively alleviate the clinical symptoms of osteoarthritis.
OBJECTIVE: To investigate the mechanism by which EA treatment inhibits osteoarthritis inflammation and protects the function of articular cartilage.
METHODS: SD rat models of osteoarthritis were established by double knee joint cavity injection of papain. Osteoarthritis rat models were treated with EA at EX-LE4 and EX-LE5 for 5, 15 and 30 minutes per day.
RESULTS AND CONCLUSION: Compared with the model group, substance P in blood and interleukin 1, interleukin 6, tumor necrosis factor α, matrix metalloproteinase 3 concentrations in synovial fluid were significantly reduced, leptin in blood and matrix metalloproteinase 1 in synovial fluid were significantly increased (P < 0.05), and the degree of cartilage degeneration was significantly alleviated (P < 0.05, P < 0.01) in osteoarthritis rat models after treatment with EA for 15 and 30 minutes per day  (P < 0.05). These results showed that EA can effectively alleviate the inflammatory reaction and postpone articular cartilage degeneration in osteoarthritis. 

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