中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (48): 9027-9030.doi: 10.3969/j.issn.1673-8225.2011.48.024

• 骨与关节图像与影像 bone and joint imaging • 上一篇    下一篇

正电子发射断层成像/CT观察健康人空腹时不同器官对18F脱氧葡萄糖的摄取

徐  郁1，2，李爱梅3，郭万华3，胡  云1   

  1. 南京大学医学院附属鼓楼医院，1内分泌科，3核医学科，江苏省南京市  210008；2江苏省南通市通州区人民医院，江苏省南通市226300
  • 收稿日期:2011-04-01 修回日期:2011-10-08 出版日期:2011-11-26 发布日期:2011-11-26
  • 通讯作者: 胡云，硕士生导师，教授，南京大学医学院附属鼓楼医院，江苏省南京市210008 huyundr@gmail.com
  • 作者简介:徐郁★，女，1985年生，江苏省南通市人，汉族，硕士，主要从事内分泌临床医学研究。uuxy@sohu.com
  • 基金资助:

    南京市医学重点科技发展项目(ZKX10016)。

Assessment of 18F-fluorodeoxyglucose uptake in different organs detected with positron emission tomography/CT in healthy adults during fasting

Xu Yu1,2, Li Ai-mei3, Guo Wan-hua3, Hu Yun1   

  1. 1Department of Endocrinology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing  210008, Jiangsu Province, China; 2People's Hospital of Tongzhou District, Nantong  226300, Jiangsu Province, China; 3Department of Nuclear Medicine, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing  210008, Jiangsu Province, China
  • Received:2011-04-01 Revised:2011-10-08 Online:2011-11-26 Published:2011-11-26
  • Contact: Hu Yun, Master’s supervisor, Professor, Department of Endocrinology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China huyundr@gmail.com
  • About author:Xu Yu★, Master, Department of Endocrinology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China; People's Hospital of Tongzhou District, Nantong 226300, Jiangsu Province, China uuxy@sohu.com
  • Supported by:

    Nanjing Medical Key Technology Development Project, No. ZKX10016*

PDF

386

摘要：

背景：既往国内外研究中，主要针对肿瘤患者体内葡萄糖的摄取情况，而关于正常人在空腹状态下不同器官对葡萄糖的摄取作用研究很少。
目的：正电子发射断层成像/CT观察健康人在空腹状态下不同器官对18F脱氧葡萄糖的摄取情况，分析空腹时脑、肝、肾、心脏和骨骼肌组织在糖代谢中的相关性。
方法：31例健康成年人空腹抽血测肝肾功能、血糖和血脂，并行正电子发射断层成像/CT检查，测脑、心脏、肝、肾脏和骨骼肌的18F脱氧葡萄糖的平均标准摄入值以及最大标准摄入值。
结果与结论：空腹时脑皮质18F脱氧葡萄糖的平均标准摄入值约是心脏和肾脏的两三倍，是肝脏的4倍左右，是骨骼肌的15倍。肝脏平均标准摄入值与肾脏和骨骼肌的平均标准摄入值呈显著正相关(r=0.406，0.391，P=0.023，0.030)，但肝脏的平均标准摄入值与心和脑的平均标准摄入值无相关性。结果提示空腹状态下脑组织对葡萄糖摄取最多，骨骼肌最少，心脏、肝脏和肾脏居中；空腹状态下肝脏与肾脏和骨骼肌之间对葡萄糖的代谢存在显著相关性。

关键词: 正电子发射断层成像/CT, 18F脱氧葡萄糖, 标准摄入值, 糖代谢, 组织

Abstract:

BACKGROUND: Previous studies in home and aborad were mainly focus on glucose uptake of cancer patient in vivo, but few studies for glucose intake in different organs of normal people under fasting.
OBJECTIVE: To observe 18F-fluorodeoxyglucose (FDG) uptake of different organs in healthy adults under fasting by using positron emission tomography (PET)/CT and to analysis the correlation of glycometabolism and healthy adults with brain, liver, kidney, heart and skeletal muscle tissue.
METHODS: Totally 31 healthy adults were treated with liver and kidney functions, blood glucose and triglyceride conventionally test under fasting. Mean and maximum standardized uptake value (SUV) of 18F-FDG with brain, heart, liver, kidney and skeletal muscle were detected by combined PET/CT scanner.
RESULTS AND CONCLUSION: Under fasting, SUV mean of 18F-FDG in brain was two or three times larger than that in heart and kidney, about four times larger than that in liver and 15 times larger than that in skeletal muscle. There were significant positive interrelationships of SUV mean among skeletal muscle, kidney and liver (r=0.406, 0.391, P=0.023, 0.030), but the SUV mean in kidney was no correlation with the heart and brain. It is indicated that under fasting, the quantity of glucose uptake of brain is greater, while of skeletal muscle is fewer, and of heart, liver, kidney is between the brain and the skeletal muscle tissue. There is a significant correlation of glycometabolism among liver, kidney and skeletal muscle under fasting.

中图分类号: