中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (47): 8817-8820.doi: 10.3969/j.issn.1673-8225.2011.47.019

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

镍钛形状记忆合金表面改性后的血液相容性

路  坦1，田  博2，张江峰1，吴大鹏1，徐海斌1   

  1. 1新乡医学院第一附属医院骨外科，河南省新乡市  453100
    2贵州大学材料科学与冶金工程学院，贵州省贵阳市550003
  • 收稿日期:2011-07-04 修回日期:2011-09-19 出版日期:2011-11-19 发布日期:2011-11-19
  • 作者简介:路坦★，男，1982年生，河南省林州市人，汉族，硕士研究生，医师，主要从事脊柱外科及骨组织工程的研究。 lutan1982@163.com

Effect of surface treatment on the hemocompatibility of Ni-Ti shape memory alloy

Lu Tan1, Tian Bo2, Zhang Jiang-feng1, Wu Da-peng1, Xu Hai-bin1   

  1. 1Department of Orthopedic Surgery, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang  453100, Henan Province, China
    2College of Materials Science and Metallurgy Engineering, Guizhou University, Guiyang  550003, Guizhou Province, China
  • Received:2011-07-04 Revised:2011-09-19 Online:2011-11-19 Published:2011-11-19
  • About author:Lu Tan★, Studying for master’s degree, Department of Orthopedic Surgery, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, Henan Province, China lutan1982@163.com

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534

被引次数

5

摘要：

背景：镍钛形状记忆合金植入人体内必需要有很好的生物相容性和生物安全性。
目的：观察分析镍钛形状记忆合金表面改性后对其生物相容性的影响。
方法：将镍钛形状记忆合金随机分为两组，经阴极电沉积法处理的材料为实验组，未经处理的为空白组，通过扫描电镜观察实验组材料表面的变化，并测定材料的溶血率和动态凝血时间。体外培养骨髓基质干细胞，与两组材料复合培养，通过MTT法检测两组材料中细胞存活数量。
结果与结论：镍钛形状记忆合金表面改性后，表面出现由很多的纳米级颗粒紧密聚集形成的Ti-O膜，实验组材料的溶血率下降，凝血时间延长，两组材料与骨髓基质干细胞复合培养第2，4，6天，实验组吸光度比空白组明显增高(P < 0.05)。说明镍钛形状记忆合金经阴极电沉积法表面改性后具有较好的生物相容性和生物安全性。

关键词: 镍钛形状记忆合金, 阴极电沉积, 溶血率, 动态凝血时间, 组织相容性

Abstract:

BACKGROUND: Implantable Ni-Ti shape memory alloys must have better biocompatibility and biological security.
OBJECTIVE: To investigate the effect of surface treatment on the biocompatibility of Ni-Ti shape memory alloy.
METHODS: Ni-Ti shape memory alloy was randomly divided into two groups: experiment group’s materials were surface-treated by cathode electrodeposition; the others not treated were belonged to blank group. We observed the changes of material surface by scanning electron microscope and evaluated the hemolysis rate and kinetic coagulation time. The bone marrow stromal stem cells were cultured with two groups’ materials in vitro, and then we evaluated the MTT value of the two groups.
RESULTS AND CONCLUSION: After surface treatment of Ti-Ni shape memory alloy, there were many nano-size particles on its surface that formatting Ti-O. In the experimental group, the hemolysis rate was decreased and the kinetic coagulation time was prolonged. The MTT values in the experimental group were significantly higher than those in the blank group at the 2nd, 4th and 6th days after co-culture (P < 0.05). Ni-Ti shape memory alloy treated by cathode electrodeposition has the better biocompatibility and biological security.

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