中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (38): 7209-7212.doi: 10.3969/j.issn.1673-8225.2011.38.043

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

不同双联抗血小板治疗时间对FIREBIRD支架置入患者的影响

郭予洁，韦金儒   

  1. 柳州市人民医院(广西医科大学第五附属医院)心内科，广西壮族自治区柳州市  
    545006
  • 收稿日期:2010-12-29 修回日期:2011-03-14 出版日期:2011-09-17 发布日期:2011-09-17
  • 通讯作者: 韦金儒，博士，主任医师，柳州市人民医院(广西医科大学第五附属医院)心内科，广西壮族自治区柳州市 545006
  • 作者简介:郭予洁★，女， 1979年生，广西壮族自治区柳州市人，汉族，2009年广西医科大学毕业，硕士，主治医师，主要从事冠心病及先天性心脏病研究。 X.guoyujie@163.com

Effects of different dual antiplatelet therapies periods on patients with coronary heart disease treated by firebird stents

Guo Yu-jie, Wei Jin-ru   

  1. Department of Cardiology, Liuzhou People’s Hospital, the Fifth Affiliated Hospital, Guangxi Medical University, Liuzhou  545006, Guangxi Zhuang Autonomous Region, China
  • Received:2010-12-29 Revised:2011-03-14 Online:2011-09-17 Published:2011-09-17
  • Contact: Wei Jin-ru, Doctor, Chief physician, Department of Cardiology, Liuzhou People’s Hospital, the Fifth Affiliated Hospital, Guangxi Medical University, Liuzhou 545006, Guangxi Zhuang Autonomous Region, China
  • About author:Guo Yu-jie★, Master, Attending physician, Department of Cardiology, Liuzhou People’s Hospital, the Fifth Affiliated Hospital, Guangxi Medical University, Liuzhou 545006, Guangxi Zhuang Autonomous Region, China X.guoyujie@163.com

PDF

266

被引次数

3

摘要：

背景：研究表明，支架内血栓直接影响了药物洗脱支架置入后近远期疗效。
目的：观察分析不同时间的双联抗血小板治疗对Firebird支架置入后冠心病患者心血管不良事件发生率的影响。
方法：选择置入Firebird国产雷帕霉素洗脱支架的患者1 107例，分为阿司匹林+硫酸氯吡格雷3月以内、3~6个月、< 6~12个月组，记录患者心血管不良事件发生率，药物不良反应的发生率及材料宿主反应。
结果与结论：实际随访例数为1 059例(共置入支架1 431枚)，随访时间由7~59个月不等，临床随访率为95.7%。3月以内、3~6个月、< 6~12个月组患者主要心血管不良事件(MACE)发生率分别为8.9%，7.7%，4.4%，差异有显著性意义。3组患者心力衰竭、急性心肌梗死、再次血运重建和主要心脏事件发生率差异均有显著性意义(P < 0.05或< 0.01)，< 6~12个月组发生率最低。各组患者均未发生材料宿主反应。提示，国产Firebird雷帕霉素洗脱支架置入后延长口服氯吡格雷时间至12个月甚至更长患者心血管事件的发生率降低，且不增加药物不良事件的发生率。

关键词: 药物洗脱支架, 氯吡格雷, 心血管不良事件, 药物不良反应, 雷帕霉素

Abstract:

BACKGROUND: The stent thrombosis has a direct impact on the immediate and long-term outcomes following drug eluting stents implantation.
OBJECTIVE: To evaluate the effects of different dual antiplatelet therapies periods on the incidence of cardiovascular adverse events in patients with coronary heart disease treated by Firebird stents
METHODS: A total of 1 107 consecutive patients with coronary artery disease who received Firebird stent implantation were selected. These patients were divided into three groups based on the time of applying asprin and clopidogrel. Major adverse cardiac events (MACE), drug adverse effect and host response to materials were recorded.
RESULTS AND CONCLUSION: 1 059 cases with 1 431 stents were followed up for 7-59 months, and clinical follow-up rate was 95.7%. Rate of MACE occurrence in the group of applying asprin and clopidogrel over 6 months (4.4%) were much lower than other groups (8.9% and 7.7%), there was significant difference among these groups (P < 0.05). Rate of non-fatal myocardial infarction, heart fail, target vessel revascularization and bleeding occurrence in the group of applying asprin and clopidogrel over 6 months were much lower than other groups, there was significant difference among these groups (P < 0.05 or < 0.01). There was no host response to materials in the three groups. The clinical follow-ups showed that the group of applying asprin and clopidogrel until 12 months has a definite clinical efficacy in the patients with coronary artery disease who received Firebird stent implantation, which could reduce the occurrence of MACEs.

中图分类号: