中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (37): 7005-7008.doi: 10.3969/j.issn.1673-8225.2011.37.039

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

去神经支配骨骼肌萎缩的多种治疗

陈  波1，陈振兵2，杜远立1   

  1. 1三峡大学人民医院骨科，湖北省宜昌市  443000
    2华中科技大学同济医学院协和医院手外科，湖北省武汉市 430022
  • 收稿日期:2011-04-06 修回日期:2011-07-09 出版日期:2011-09-10 发布日期:2011-09-10
  • 作者简介:陈波★，男，1971年生，湖北省随州市人， 2010年华中科技大学同济医学院毕业，硕士，副主任医师，主要从事创伤外科和手外科的诊治。 chenbo71@ sina.com

Multiple treatments for denervated skeletal muscle atrophy

Chen Bo1, Chen Zhen-bing2, Du Yuan-li1   

  1. 1Department of Orthopedics, People’s Hospital of China Three Gorges University, Yichang  443000, Hubei Province, China
    2Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
  • Received:2011-04-06 Revised:2011-07-09 Online:2011-09-10 Published:2011-09-10
  • About author:Chen Bo★, Master, Associate chief physician, Department of Orthopedics, People’s Hospital of China Three Gorges University, Yichang 443000, Hubei Province, China chenbo71@sina.com

PDF

307

被引次数

6

摘要：

背景：骨骼肌去神经支配后出现肌萎缩和收缩功能的丧失，肌纤维发生与萎缩相关的一系列的形态学和组织学的变化。近年来随着技术水平及理论研究的进展，治疗效果有了较大的提高，但仍未达到满意的效果。
目的：总结并讨论近年来有关去神经支配骨骼肌萎缩的治疗新进展，为肌肉功能的恢复提供理论基础。
方法：由第一作者用计算机检索中国期刊全文数据库(CNKI：2000/2010)和Medline数据库(2000/2010)，检索词分别为“去神经支配，骨骼肌，肌萎缩，治疗”和“denervated，skeletal muscles，atrophy，treatment”。共检索到135篇文章，按纳入和排除标准对文献进行筛选，共纳入30篇文章，从物理治疗、神经修复和植入、细胞移植、药物、基因和中药治疗等方面进行总结和分析。
结果与结论：近年来去神经支配骨骼肌的治疗取得了很大进展，但这些方法只能在一定程度上缓解骨骼肌萎缩，在一段时间内维持肌肉的生理功能。目前研究随着去神经支配骨骼肌萎缩机制的阐明，针对性的治疗措施将会取得更好的效果。

关键词: 去神经支配, 骨骼肌, 肌萎缩, 治疗, 组织工程

Abstract:

BACKGROUND: Following denervation, the loss of contractile function and amyotrophy occur in skeletal muscle, and myofibers show a series of histomorphological changes concerning amyotrophy. With progress in technical levels and theory research, considerable improvement in the treatment effects have been achieved, but it is not satisfactory.
OBJECTIVE: To summarize and discuss the recent progress in treatment methods of denervated skeletal muscles atrophy and provide theoretical evidence for recovery of muscle function.
METHODS: A computer-based retrieval was performed by the first author in the CNKI and Medline databases to search papers published between 2000 and 2010 using key words “denervated, skeletal muscles, atrophy, treatment” in Chinese and English languages. A total of 135 papers were retrieved. According to inclusion and exclusion criteria, 30 papers were included in the final analysis. These included papers were summarized and analyzed from the aspects of physiotherapy, nerve repair and implantation, cell transplantation, drug, gene and traditional Chinese medicine treatment.
RESULTS AND CONCLUSION: Great progress has been recently made in treatment of denervated skeletal muscles. However, the methods used can only alleviate skeletal muscle atrophy to an extent and maintain muscular physiological function for a time period. The mechanism underlying denervated skeletal muscle atrophy has been clarified and the corresponding measures would acquire better therapeutic effects.

中图分类号: