中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (37): 6956-6958.doi: 10.3969/j.issn.1673-8225.2011.37.027

• 组织构建与中医药 tissue construction and traditional Chinese medicine • 上一篇    下一篇

红花黄色素可促进人脐静脉内皮细胞的增殖

孙玉芹1, 2，韩海玲2，宋文刚2，朱玉红3，吕冬燕1，朱艳彬2，何海涛2，姜  欣2   

  1. 1吉林大学基础医学院病理生理学教研室，吉林省长春市 132011
    2北华大学附属医院心脑科，吉林省吉林市 132011
    3吉林市水务集团职工医院，吉林省吉林市 132011
  • 收稿日期:2011-03-06 修回日期:2011-06-18 出版日期:2011-09-10 发布日期:2011-09-10
  • 通讯作者: 孙玉芹，1969年生，女，汉族，北华大学附属医院心脑科，副主任，副教授，硕士生导师。主要从事神经及心脑血管病诊治及基础研究。 1206hhl@sina.com
  • 作者简介:孙玉芹，1969年生，女，汉族，北华大学附属医院心脑科，副主任，副教授，硕士生导师。主要从事神经及心脑血管病诊治及基础研究。 1206hhl@sina.com
  • 基金资助:

    课题受吉林省教育厅“十一五”重大科学技术攻关项目(2010123)资助。

Hydroxysafflor yellow A promotes the proliferation of human umbilical vein endothelial cells

Sun Yu-qin1, 2, Han Hai-ling2, Song Wen-Gang2, Zhu Yu-Hong3, Lü Dong-Yan1, Zhu Yan-bin2, He Hai-tao2, Jiang Xin2   

  1. 1Department of Pathophysiology, School of Basic Medical Sciences, Jilin University, Changchun  130021, Jilin Province, China
    2Department of Cardiology and Brain, Affiliated Hospital of Beihua University, Jilin  132011, Jilin Province, China
    3Workers Hospital of Jilin Water Group Co.,Ltd., Jilin  132011, Jilin Province, China
  • Received:2011-03-06 Revised:2011-06-18 Online:2011-09-10 Published:2011-09-10
  • Contact: Sun Yu-qin, Associate professor, Master’s supervisor, Department of Pathophysiology, School of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin Province, China; Department of Cardiology and Brain, Affiliated Hospital of Beihua University, Jilin 132011, Jilin Province, China 1206hhl@sina.com
  • About author:Sun Yu-qin, Associate professor, Master’s supervisor, Department of Pathophysiology, School of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin Province, China; Department of Cardiology and Brain, Affiliated Hospital of Beihua University, Jilin 132011, Jilin Province, China 1206hhl@sina.com
  • Supported by:

    Major Technology R&D Program of Education Department of Jilin Province during 11th Five-Year Plan Period, No.2010123*

PDF

251

被引次数

6

摘要：

背景：心血管疾病的发生、发展与内皮细胞增生及凋亡有关。
目的：观察红花黄色素对血管内皮细胞模型的保护作用。
方法：体外培养人脐静脉内皮细胞，先采用红花黄色素进行干预，随后采用溶血卵磷脂体外诱导建立人脐静脉内皮细胞损伤模型，并设置对照组。
结果与结论：与对照组比较，溶血卵磷脂干预的人脐静脉内皮细胞增殖减弱(P < 0.05)，细胞凋亡增加(P < 0.05)，一氧化氮浓度降低(P < 0.01)，而经红花黄色素干预后上述现象均可被逆转(P < 0.05)。结果证实，红花黄色素可通过促进内皮细胞增殖，抑制其凋亡并增加一氧化氮浓度对溶血卵磷脂诱导的内皮细胞损伤起保护作用。

关键词: 红花黄色素, 血管内皮细胞, 溶血卵磷脂, 增殖细胞凋亡, 组织工程

Abstract:

BACKGROUND: The occurrence and development of cardiovascular diseases are related to the proliferation and apoptosis of vascular endothelial cells (VECs).
OBJECTIVE: To investigate the protective effects of hydroxysafflor yellow A (HSYA) on human VEC (hVEC) models.
METHODS: The hVECs cultured in vitro were interfered with HSYA and then were established into hVEC injury models by in vitro induction of lysophosphatidyl choline. A control group was set.
RESULTS AND CONCLUSION: Compared with the control group, hVECs proliferation was significantly decreased (P < 0.05), cell apoptosis was significantly increased (P < 0.05) and nitric oxide concentration was significantly decreased (P < 0.01) after lysophosphatidyl choline intervention. However, after treatment with HSYA, these symptoms could be reversed (P < 0.05). Results showed that HSYA could promote the proliferation of hVECs, inhibit cell apoptosis, and increase nitric oxide concentration, exhibiting protective effects on lysophosphatidyl choline-induced injury to hVECs.

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