中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (16): 2937-2940.doi: 10.3969/j.issn.1673-8225.2011.16.020

• 生物材料综述 biomaterial review • 上一篇    下一篇

经皮穿刺椎体后凸成形术中骨水泥与硫酸钙应用的对比

白  明，银和平   

  1. 内蒙古医学院第二附属医院微创脊柱外科，内蒙古自治区呼和浩特市  010030
  • 收稿日期:2010-12-12 修回日期:2011-03-16 出版日期:2011-04-16 发布日期:2013-11-11
  • 作者简介:白明★，男，1981年生，内蒙古自治区呼和浩特市人，蒙古族，内蒙古医学院在读硕士，医师，主要从事微创脊柱外科研究。 baiming156@sina.com

Calcium sulfate cement versus polymethylmethacrylate in percutaneous kyphoplasty

Bai Ming, Yin He-ping   

  1. Department of Microinvasive Spinal Surgery, Second Affiliated Hospital of Inner Mongolia Medical College, Hohhot  010030, Inner Mongolia Autonomous Region, China
  • Received:2010-12-12 Revised:2011-03-16 Online:2011-04-16 Published:2013-11-11
  • About author:Bai Ming★, Studying for master’s degree, Physician, Department of Microinvasive Spinal Surgery, Second Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010030, Inner Mongolia Autonomous Region, China baiming156@sina.com

PDF

311

被引次数

6

摘要：

背景：近几年采用球囊扩张椎体后凸成形术治疗老年骨质疏松性椎体压缩骨折获得很好临床疗效，但其使用的传统填充物骨水泥有诸多缺点，而可注射硫酸钙是一种生物相容性好，安全有效的骨替代材料，作为充填强化的方法，弥补了骨水泥的不足。
目的：分析和总结1975年以来骨水泥与可注射硫酸钙在椎体后凸成形术中的应用研究，寻求适合椎体后凸成形术中的理想新型充填材料。
方法：分别以“骨质疏松症，椎体后凸成形术，硫酸钙，骨水泥”，“Osteoporosis、percutaueous kyphoplasty(PKP)、calcium sulfate cement(CSC)、polymethylmethacrylate(PMMA)”为检索词，应用计算机检索万方数据库及PubMed 数据库1975-01/2009-12有关文章。纳入有关椎体后凸成形术填充材料的文献，排除与研究目的无关和内容重复者，保留25篇文献做进一步分析。
结果与结论：目前骨水泥(PMMA)仍是临床上最常用的椎体成形材料，适合应用于严重骨质疏松性椎体骨折的治疗，但还存在骨水泥的渗漏等诸多缺点。可注射硫酸钙作为填充物生物相容性好，是安全有效的骨替代材料，其抗压强度相当于松质骨，可用于负重，无聚热反应(< 30 ℃)，即使渗漏对周围组织及神经的损害很小，可完全被生物降解吸收，具有良好的微孔性，作为支架材料可吸附干细胞、成骨细胞、生物因子或化疗药物，但也存在可注射性差，止痛效果不如骨水泥明显等不足。因此研究开发出一种理想填充材料，供临床使用是今后的一项重要课题。

关键词: 骨质疏松症, 椎体后凸成形术, 硫酸钙, 骨水泥, 综述文献

Abstract:

BACKGROUND: Osteoporosis caused by the vertebral fractures in orthopedic clinical disease is very common; due to pain, kyphosis affects the quality of life of older persons. In recent years using balloon kyphoplasty (PKP) treatment of the disease to obtain good clinical, but its use of traditional bone cement filler has many shortcomings, and injectable calcium sulfate is a biocompatible, safe and effective bone substitute material, as the method of filling enhanced to make up for the lack of bone cement.
OBJECTIVE: By analyzing and summarizing bone cement and injectable calcium sulfate in the kyphoplasty in applied research since 1975, to look for ideal filling materials for kyphoplasty.
METHODS: By using "osteoporosis, percutaueous kyphoplasty (PKP), calcium sulfate cement (CSC), polymethylmethacrylate (PMMA)" as keywords, we retrieved articles published 1975-01/2009-12 included in Wanfang database and PubMed database. Irrelevant and the repetitive contents were excluded. Twenty-five documents retained for further analysis.
RESULTS AND CONCLUSION: Ideal effective implants may be injection shall be of good, can precisely infuse fracture sites, and may reduce the injection pressure; they can rapidly be solidified, have enough mechanical strength, stable, immediately recover vertebral body load capacity; Solidification low temperature, can reduce heat damage to nearby tissue; A good imaging capabilities, can develop during the operation, which precisely control the location and depth of the filler; can be slowly biodegradable; Material origin is widespread, and cheaper prices. At present there is no a filling materials can completely have the above advantages. Therefore, the research to develop a kind of ideal filling materials for clinical use is an important task in the future.

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