中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (8): 1417-1420.doi: 10.3969/j.issn.1673-8225.2011.08.021

• 纳米生物材料 nanobiomaterials • 上一篇    下一篇

纳米银凝胶与纳米银水凝胶在模拟体液中的释放特征

周  亮1,2,3，汤京龙2，王春仁2，陈艳梅4，董  喆2，李中良1，邵安良1，周国凤1，奚廷斐1,5   

  1. 1温州医学院信息与工程学院，浙江省温州市  325035
    2中国药品生物制品检定所，北京市 100050
    3海门市人民医院，江苏省海门市  226100
    4北京大学工学院，北京市 100087
    5北京大学深圳研究院，广东省深圳市 518057
  • 收稿日期:2010-11-22 修回日期:2011-01-05 出版日期:2011-02-19 发布日期:2011-02-19
  • 通讯作者: 奚廷斐，博士生导师，研究员，温州医学院信息与工程学院，浙江省温州市 325035；北京大学深圳研究院，广东省深圳市 518057 xitingfei@tom.com
  • 作者简介:周亮★，男，1984年生，湖北省洪湖市人，汉族，温州医学院信息与工程学院在读硕士，主要从事纳米银生物安全性的研究。 cannychow@foxmail.com

Release characteristics of nano-silver gel versus nano-silver hydrogel in simulated body fluid

Zhou Liang1,2,3, Tang Jing-long2, Wang Chun-ren2, Chen Yan-mei4, Dong Zhe2, Li Zhong-liang1, Shao An-liang1, Zhou Guo-feng1, Xi Ting-fei1,5   

  1. 1School of Information & Engineering, Wenzhou Medical College, Wenzhou  325035, Zhejiang Province, China
    2National Institute for the Control of Pharmaceutical and Biological Products, Beijing  100050, China
    3Haimen Municipal People’s Hospital, Haimen  226100, Jiangsu Province, China
    4College of Engineering, Peking University, Beijing  100087, China
    5Shenzhen Research Institute, Peking University, Shenzhen  518057, Guangdong Province, China
  • Received:2010-11-22 Revised:2011-01-05 Online:2011-02-19 Published:2011-02-19
  • Contact: Xi Ting-fei, Doctoral supervisor, Researcher, School of Information & Engineering, Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China; Shenzhen Research Institute, Peking University, Shenzhen 518057, Guangdong Province, China xitingfei@tom.com
  • About author:Zhou Liang★, Studying for master’s degree, School of Information & Engineering, Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China; National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China; Haimen Municipal People’s Hospital, Haimen 226100, Jiangsu Province, China cannychow@foxmail.com

PDF

511

被引次数

9

摘要：

背景：国内外研究显示，纳米银颗粒可在体内迁移、蓄积，并最终导致细胞毒性和基因毒性，且毒性可由于纳米银的蓄积而逐渐扩大。
目的：观察纳米银凝胶和纳米银水凝胶两类产品在模拟体液中的释放特征。
方法：取来自6个厂家的6种纳米银产品(3种纳米银凝胶和3种纳米银水凝胶)，将其浸泡在模拟体液中，提取不同时间点的纳米银凝胶和纳米银水凝胶释放液，利用超高压微波消解系统消解并定容，再用原子吸收光谱仪检测各消解液中的银含量，根据银含量检测结果分析总结两类产品在模拟体液中的释放特征。
结果与结论：3种纳米银凝胶在模拟体液中的释放速率分别为3.59，4.30，1.17 g/min，达到动态平衡的时间分别为40，35，70 min；3种纳米银水凝胶在模拟体液中的释放速率分别为5.14，5.31，4.86 g/s，达到动态平衡的时间均为100 s。提示由于载体基质的不同，纳米银水凝胶的释放速率要明显高于纳米银凝胶；不同纳米银厂家由于工艺的不同，纳米银凝胶的释放速率亦有所不同，而纳米银水凝胶的释放速率区别不大。

关键词: 纳米银凝胶, 纳米银水凝胶, 释放特征, 模拟体液, 生物材料与纳米技术

Abstract:

BACKGROUND: Researches at home and abroad demonstrate that silver nanoparticles can migrate and accumulate in vivo, eventually leading to cytotoxicity and genotoxicity which increases with the accumulation level.   
OBJECTIVE: To observe the release characteristics of nano-silver gel and nano-silver hydrogel in simulated body fluid.
METHODS: Three kinds of nano-silver gel and three kinds of nano-silver hydrogel from six manufacturers were soaked in simulated body fluid, the release liquid was extracted at different time points, and then harvested for silver content analysis by using the extra high pressure microwave and the atom absorption spectrum instrument, at last, the release characteristics of these were analyzed and summarized.
RESULTS AND CONCLUSION: In the simulated body fluid, the release rate of three kinds of nano-silver gel was 3.59, 4.30 and 1.17 g/min respectively, the time to reach dynamic equilibrium was 40, 35, 70 minutes respectively; by comparison, the release rate of three kinds of nano-silver hydrogel was 5.14, 5.31 and 4.86 g/s respectively, the time to reach dynamic equilibrium was all 100 seconds. Due to the difference of carrier matrix, the release rate of nano-silver hydrogel was significantly higher than the nano-silver gel; different manufacturers and different techniques of silver nanoparticles, may lead to altered release rates of nano-silver gel, while the release rate of nano-silver hydrogel was not different.

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