中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (4): 671-674.doi: 10.3969/j.issn.1673-8225.2011.04.024

• 骨与关节图像与影像 bone and joint imaging • 上一篇    下一篇

正常犬肺动脉三维CT重建中不同剂量对比剂的比较

李国策1,王志铭2,雷  振1,钱  颖2,徐  娜1,张  军1,郑石磊1   

  1. 1辽宁医学院附属第一医院放射线科,辽宁省锦州市   121001
    2辽宁医学院附属第三医院,辽宁省锦州市    121001
  • 收稿日期:2010-09-26 修回日期:2010-11-02 出版日期:2011-01-22 发布日期:2011-01-22
  • 通讯作者: 王志铭,教授,硕士生导师,辽宁医学院附属第三医院,辽宁省锦州市 121001 zhiming1012005@yahoo.com.cn
  • 作者简介:李国策★,男,1982年生,河北省沧县人,汉族,辽宁医学院在读硕士,主要从事CT诊断及图像处理方面研究。 liguocewy@163.com
  • 基金资助:

    辽宁省自然科学基金项目(2009526),课题名称:低浓度低剂量碘对比剂降低肾脏损害的实验研究。

Comparison of different dose contrast media in three-dimensional CT reconstruction of healthy canine pulmonary artery

Li Guo-ce1, Wang Zhi-ming2, Lei Zhen1, Qian Ying2, Xu Na1, Zhang Jun1, Zheng Shi-lei1   

  1. 1Department of Radiology, First Affiliated Hospital of Liaoning Medical University, Jinzhou  121000, Liaoning Province, China
    2Third Affiliated Hospital of Liaoning Medical University, Jinzhou  121000, Liaoning Province, China
  • Received:2010-09-26 Revised:2010-11-02 Online:2011-01-22 Published:2011-01-22
  • Contact: Wang zhi-ming, Professor, Master’s supervisor, Third Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China zhiming1012005@ yahoo.com.cn
  • About author:Li Guo-ce★, Studying for master’s degree, Department of Radiology, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China liguocewy@163.com
  • Supported by:

    Liaoning Provincial Natural Science Foundation, No. 2009526*

摘要:

背景:行CT血管成像时,需要静脉注入碘对比剂,并且随着对比剂应用剂量的增大,对患者带来的危害也相应增大。
目的:验证低剂量对比剂在多层螺旋CT肺动脉成像中的可行性。
方法:12只健康家犬参照临床上人的碘海醇(300 mgI/mL)使用剂量,根据《药理实验中动物间和动物与人体间的等效剂量换算》得出相应犬的3个剂量组分别为碘海醇2.40 mL/kg,2.02 mL/kg,1.62 mL/kg组。12只犬分别接受3种剂量各1次,每次实验扫描间隔时间至少48 h,共进行36次CT扫描。根据原始图像、容积重现像和最大密度投影像,对3种方案肺动脉分支的显示情况、肺动脉边缘清晰程度及肺静脉充盈程度进行评分,并测量肺动脉内对比剂的浓度。
结果与结论:3种方案均能清晰显示犬肺动脉4级分支,血管边缘清晰,显示程度评分各组差异无显著性意义(P > 0.05)。3种方案肺静脉显影程度均较低,与肺动脉有很好的密度对比,各组差异无显著性意义(P > 0.05)。3种方案肺动脉内的对比剂浓度均维持在较高的水平,差异无显著性意义(P > 0.05)。提示低剂量对比剂在多层螺旋CT犬肺动脉成像中是可行的,图像质量可以满足临床诊断要求,从而为临床应用低剂量对比剂行肺动脉成像提供实验依据。

关键词: 肺动脉, 对比剂, 体层摄影, 血管造影, 数字化影像技术

Abstract:

BACKGROUND: CT angiograph needs that the contrast media injects into vein, and the greater the dose of contrast media, the greater the hazard to patients.
OBJECTIVE: To validate the feasibility of low dose contrast media in spiral CT pulmonary artery angiograph. 
METHODS: A total of 12 healthy canis familiaris with reference to iohexol dose of human in clinic, according to “equivalent dose conversion of animals and between animals and humans in pharmacological experiments”, which got the corresponding three dose groups: iohexol 2.40 mL/kg group, iohexol 2.02 mL/kg group, iohexol 1.62 mL/kg group. Twelve canis familiaris were treated with 3 kinds of doses for once; scan interval of each experiment was at least 48 hours, a total of 36 CT scans. Pulmonary artery branch conditions, pulmonary vein edge clarity, and filling degree of pulmonary vein of 3 proposals were scored by original image, volume recurrence image, and maximum intensity projection image, and the concentration of contrast media in pulmonary artery was measured
RESULTS AND CONCLUSION: Three kinds of proposals can clearly show 4 branches of canines’ pulmonary artery, the edge of vascular is clear. There was no significant difference in each group (P > 0.05). The degree of pulmonary vein imaging was lowered, and had a good density comparison with pulmonary artery; there was no significant difference in each group (P > 0.05). The concentration of contrast media in pulmonary artery maintained at a high level, there was no significant difference (P> 0.05). It is indicated that it is feasible to use low dose contrast media in multislice spiral CT pulmonary artery angiograph of canines, the image quality can meet the clinical diagnostic requirements to provide the experimental basis of pulmonary artery angiograph with low dose contrast media for clinical application.

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