中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (2): 339-342.doi: 10.3969/j.issn.1673-8225.2011.02.037

• 组织构建综述 tissue construction review • 上一篇    下一篇

骨保护素和碱性成纤维细胞生长因子在牙周组织再生中的应用

何世海1，陈乔尔1, 2   

  1. 1安徽医科大学口腔医学院附属口腔医院，安徽省合肥市  230032
    2安徽省口腔疾病研究省级实验室，安徽省合肥市230032
  • 收稿日期:2010-09-02 修回日期:2010-10-09 出版日期:2011-01-08 发布日期:2011-01-08
  • 通讯作者: 陈乔尔，教授，主任医师，硕士生导师，安徽医科大学口腔医学院附属口腔医院，安徽省合肥市 230032； 安徽省口腔疾病研究省级实验室，安徽省合肥市230032 chqe0111@163.com
  • 作者简介:何世海★，男，1970年生，河北省承德市人，汉族，安徽医科大学口腔医学院在读硕士，主治医师，主要从事口腔颌面肿瘤和口腔组织病理方面的研究。 heshihai1970@ sina.com
  • 基金资助:

    常州市社会发展科技计划资金资助(CS20092023)，项目名称“共表达骨保护素和成纤维细胞生长因子重组腺病毒治疗重症牙周病的实验研究”。

Application of osteoprotegerin and basic fibroblast growth factor in periodontal regeneration

He Shi-hai1, Chen Qiao-er1, 2   

  1. 1Stomatology Hospital, College of Stomatology, Anhui Medical University, Hefei  230032, Anhui Province, China
    2Anhui Provincial Laboratory of Oral Disease Research, Hefei  230032, Anhui Province, China
  • Received:2010-09-02 Revised:2010-10-09 Online:2011-01-08 Published:2011-01-08
  • Contact: Chen Qiao-er, Professor, Chief physician, Master’s supervisor, Stomatology Hospital, College of Stomatology, Anhui Medical University, Hefei 230032, Anhui Province, China; Anhui Provincial Laboratory of Oral Disease Research, Hefei 230032, Anhui Province, China chqe0111@163.com
  • About author:He Shi-hai★, Studying for mater’s degree, Attending physician, Stomatology Hospital, College of Stomatology, Anhui Medical University, Hefei 230032, Anhui Province, China heshihai1970@sina. com
  • Supported by:

    the Science and Technology Plan for Society Development of Changzhou City, No. CS20092023

PDF

383

被引次数

17

摘要：

背景：利用组织工程和基因治疗技术，联合应用骨保护素和碱性成纤维细胞生长因子可以促进牙周组织修复再生，是治疗重症牙周病的新方法。
目的：探讨联合应用骨保护素和碱性成纤维细胞生长因子以促进牙周组织修复再生的理论依据。
方法：应用计算机检索PubMed数据库(1996/2009)和中国知网数据库(1999/2009)，分别以“osteoprotegerin，basic fibroblast growth factor，tissue engineering, gene therapy，periodontal regeneration”和“骨保护素、碱性成纤维细胞生长因子、组织工程、基因治疗、牙周组织修复再生”为检索词，通过阅读标题和摘要进行初筛，排除较陈旧和重复研究文献，保留符合纳入标准的文献29篇。
结果与结论：使牙槽骨、牙周膜和牙骨质获得再生，形成牙周新附着一直是口腔医学研究的热点。骨保护素是一种能阻止破骨细胞分化、促进骨形成的关键因子。碱性成纤维细胞生长因子在胚胎发育，血管生成，骨的形成和修复，促进细胞增生等有广泛的作用。2者都可促进牙周组织的修复和再生。组织工程技术和基因治疗技术的出现显著促进了牙周组织修复再生研究的发展，有选择地复合这2种生长因子促进牙周支持组织的再生和修复可成为治疗牙周病的一种新方法。

关键词: 骨保护素, 碱性成纤维细胞生长因子, 牙周组织修复再生, 基因治疗, 组织工程

Abstract:

BACKGROUND: Combination of osteoprotegerin and basic fibroblast growth factor can improve periodontal regeneration applying tissue engineering and gene therapy.
OBJECTIVE: To summarize theoretical basis for applying osteoprotegerin and basic fibroblast growth factor to improve periodontal regeneration.
METHODS: Relevant articles in PubMed (1996-2009) and CNKI (1999-2009) were searched by computer with the key words of “osteoprotegerin, basic fibroblast growth factor, tissue engineering, gene therapy, periodontal regeneration”. Articles addressing originality identification, reliability, general analysis, and high correlation were included. Exclusive criteria: repetitive and obsolescent articles. A total of 29 articles were reserved for review.
RESULTS AND CONCLUSION: How to obtain periodontal regeneration and to form new attachment is constantly hot spot in oral medicine research. Osteoprotegerin is a key factor in preventing osteoclasts differentiation and promoting bone formation. Basic fibroblast growth factor has extensive effects on embryo development, vascularization, bone restoration, cellular proliferation, and so on. Tissue engineering and gene therapy motivated the studies of periodontal regeneration progress. The selection of osteoprotegerin and basic fibroblast growth factor might be a method of treating periodontal diseases.

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