中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (50): 9431-.doi: 10.3969/j.issn.1673-8225.2010.50.037

• 组织构建临床实践 • 上一篇    下一篇

中国北方汉族男子FECH基因rs1787997多态与耐力运动敏感性的关联

许亚丽1，胡扬2，任志军3，温  辉4   

  1. 1河南大学体育学院，河南省开封市  475000；2北京体育大学科学研究中心，北京市  100084；3江门市人民医院脑血管疾病科，广东省江门市  529000；  4洛阳市中心医院神经外科，河南省洛阳市  471000
  • 出版日期:2010-12-10 发布日期:2010-12-10
  • 作者简介:许亚丽☆，女，1979年生，河南省禹州市人，汉族，2009年北京体育大学毕业，博士，副教授，主要从事基因选材、高原训练、运动性贫血等方面的研究。 lanxin1979@163.com
  • 基金资助:

    国家科技部课题(2003BA904B04)，课题名称：优秀长跑运动员选材分子遗传学指标的研究。

Association between the rs1787997 polymorphism in FECH gene and motion sensitivity in men of Han nationality in northern China

Xu Ya-li1, Hu Yang2, Ren Zhi-jun3, Wen Hui4   

  1. 1 Physical Education College of Henan University, Kaifeng  475001, Henan Province, China; 2 Scientific Research Center, Beijing Sport University, Beijing  100084, China; 3 Department of Hematology, the People’s Hospital of Jiangmen, Jiangmen  529000, Guangdong Province, China; 4 Department of Neurosurgery, Luoyang Central Hospital, Luoyang  471000, Henan Province, China
  • Online:2010-12-10 Published:2010-12-10
  • About author:Xu Ya-li☆ Doctor, Associate professor, Physical Education College of Henan University, Kaifeng 475001, Henan Province, China lanxin1979@163.com
  • Supported by:

    the Foundation of Ministry of Science and Technology of China, No. 2003BA904B04*

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摘要：

背景：基因多态性与人体的运动能力及运动训练敏感性存在关联。亚铁螯合酶是生物体中血红素合成的最后一个酶，与人体有氧运动能力密切相关。
目的：探讨中国北方汉族男性亚铁螯合酶基因rs1787997多态性与耐力训练敏感性的关联，寻找与有氧耐力训练效果有关的分子标记。
方法：从2003-01入伍的中国武装警察某部队的新兵中选取102名中国北方汉族健康男性受试者，以95%~105%个体无氧阈强度进行5 000 m跑训练，每周3次，共18周，训练前后测定跑节省化等指标。使用PCR-RFLP和测序方法解析亚铁螯合酶基因rs1787997多态性的分布特征，并对该多态性与跑节省化进行关联性分析。
结果与结论：有氧耐力训练后，亚铁螯合酶基因CC基因型受试者在跑节省化时的通气量下降幅度显著高于GG基因型和CG基因型(P < 0.05)。说明在亚铁螯合酶基因rs1787997多态性中，CC基因型对提高跑节省化水平具有较高的训练敏感性，可作为预测有氧耐力训练敏感性的分子标记。

关键词: 亚铁螯合酶, 基因多态性, 有氧运动能力, 跑节省化, 分子标记, 关联分析

Abstract:

BACKGROUND: There is association between gene polymorphism, motor ability and training sensitivity. Ferrochelatase (FECH) is an enzyme that catalyses the terminal step in the biosynthesis of heme, which has been shown to interact with aerobic performance.
OBJECTIVE: To investigate association of rs1787997 polymorphism of FECH gene and motion sensitivity in men of Han nationality in northern China, and to explore a molecular marker in predicting endurance training response.
METHODS: Totally 102 healthy young male soldiers of Han nationality in northern China were recruited to undergo 18-week    5 000-m running with the intensity of 95%-105% anaerobic threshold, 3 times a week. The running economy was measured before and after the protocol. The PCR-RFLP and gene sequencing was used to analyze the distribution of this polymorphism. The association of the polymorphism with initial endurance capacity and endurance training response was analyzed.
RESULTS AND CONCLUSION: After 18-week 5 000-m running, the decreased degree of ventilation at RE in CC genetype was higher than GG and CG genetypes significantly (P < 0.05). In the rs1787997 polymorphism of FECH gene, CC genetype has higher training response in running economy and might be the genetic marker in predicting endurance training response.

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