中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (49): 9285-.doi: 10.3969/j.issn.1673-8225.2010.49.038

• 干细胞学术探讨 • 上一篇    下一篇

中医药参与干细胞研究相关文献的分析

张良登1，2，姚魁武1，王阶1   

  1. 1中国中医科学院广安门医院心内科，北京市 100053；2北京中医药大学针灸推拿学院，北京市 100029
  • 出版日期:2010-12-03 发布日期:2010-12-03
  • 通讯作者: 姚魁武，博士， 副主任医师，中国中医科学院广安门医院心内科，北京市 100053 yaokuiwu@yahoo.com.cn
  • 基金资助:

    首都医学发展科研基金北京医学卫生科技联合攻关项目(SF2007Ⅰ04)。

Traditional Chinese medicine in stem cells study

Zhang Liang-deng 1,2, Yao Kui-wu 1, Wang Jie1   

  1. 1Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing  100053, China; 2School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, Beijing  100029, China
  • Online:2010-12-03 Published:2010-12-03
  • Contact: Yao Kui-wu, Doctor, Associate chief physician, Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China yaokuiwu@yahoo.com.cn
  • Supported by:

     the Beijing Medical Health Science and Technology Association Program of Capital Medical Science Development Scientific Research Foundation, No. SF2007Ⅰ04*

PDF

434

被引次数

9

摘要：

背景：干细胞是再生医学研究的热点，在干细胞培养诱导过程中加入中药干预的文献报道越来越多。 
目的：通过回顾与总结近年来干细胞研究过程中加入中药干预的若干文献，旨在进一步探索中药与干细胞培养、诱导、生长，分化的相关性。 
方法：以“中医药”或“中医” 或“中医学”或“中药”及二次检索词“干细胞”为检索词，检索1991-01/2010-01期间CNKI数据库和《中文科技期刊数据库(全文版)》中收录涉及中药应用于干细胞的细胞学实验或临床研究文献进行检索，提取文献中的中药方剂、干细胞类型、应用意义、作者单位、基金资助等指标，建立数据库，进行频次分析。 
结果与结论：检索到167篇文献，符合纳入标准的文献共31篇。在干细胞培养、诱导、分化，生长中应用的中药，治法上以活血化瘀、益气、补肾填精为常见；名方、时方、验方及中药有效组分得到广泛应用，尤以益气活血、活血化瘀、补肾填精中药应用得较为集中；文献结果描述中体现了中药具有促进干细胞动员、增殖、分化等作用，可使损伤的组织器官得以修复；相关研究主要集中于国内较为发达的区域；基金资助逐年增加，以国家自然科学基金重点资助为主。中药在干细胞培养、诱导过程中的应用，使中医临证思维融合再生思想，使调和阴阳的治疗目标延伸向了干细胞治疗与再生医学的时代。

关键词: 中医药, 干细胞, 再生医学, 基金资助, 文献研究

Abstract:

BACKGROUND: Stem cells are hot topic research in regenerative medicine. More and more literatures on traditional Chinese medicine (TCM) intervention in stem cell culture have been reported.
OBJECTIVE: To further explore the correlation of TCM to culture, induction, growth and differentiation of stem cells by reviewing and summarizing studies of stem cells intervention in TCM recent years.
METHODS: We searched experiments or clinical researches literatures of stem cells intervention in TCM through China National Knowledge Infrastructure and Chinese sci-tech periodical full-text database published from January 1991 to January 2010. The key words were “TCM” or “Chinese materia medica” and second key word “stem cells”. Then, TCM prescriptions, stem cells types, application value, affiliations and funds were extracted, for setting up a database and frequency analysis. 
RESULTS AND CONCLUSION: Totally 167 documents were retrieved, only 31 of which met the inclusion criteria. The usual therapies on stem cells intervention in TCM are that removing stasis and blood circulation, tonifying qi, nourishing kidney and replenish vital essence. There is regularity between TCM therapies and stem cells types. Famous and effective prescriptions and effective TCM components are widely used, especially TCM of notifying qi, removing stasis and blood circulation, nourishing kidney and replenish vital essence. TCM can improve mobilization, proliferation and differentiation of stem cells to repair injured tissues and organs. Fund increased year by year, mainly focused by National Nature Science Foundation of China and related researches have focused on developed regions. There is solid base of theory and clinic of targeted stem cells in TCM. Targeted stem cells in TCM would integrate regenerative thought with clinical thought of TCM, extend the harmony of yin and yang to the era of stem cells and regenerative medicine.

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