中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (49): 9264-.doi: 10.3969/j.issn.1673-8225.2010.49.033

• 干细胞学术探讨 • 上一篇    下一篇

骨髓间充质干细胞对移植免疫的影响

刘银梅，张鹏   

  1. 厦门大学，福建省厦门市  361005
  • 出版日期:2010-12-03 发布日期:2010-12-03
  • 通讯作者: 张鹏，厦门大学，福建省厦门市 361005
  • 作者简介:刘银梅，主要从事血液病学方面的研究。 yinmeiliu@163.com

Effects of bone marrow mesenchymal stem cells on transplantation immunity

Liu Yin-mei, Zhang Peng   

  1. Xiamen University, Xiamen  361005, Fujian Province, China
  • Online:2010-12-03 Published:2010-12-03
  • Contact: Zhang Peng, Xiamen University, Xiamen 361005, Fujian Province, China
  • About author:Liu Yin-mei, Xiamen University, Xiamen 361005, Fujian Province, China yinmeiliu@163.com

PDF

378

被引次数

21

摘要：

背景：近年来研究发现，骨髓间充质干细胞除具有支持体外造血、促进体内造血功能重建外，还具有较低的免疫原性和抑制异体T淋巴细胞增殖的作用，在调节移植免疫方面发挥重要作用，但其机制尚不十分明确。
目的：就近年来关于骨髓间充质干细胞的免疫调节特性及其在造血干细胞移植中的作用简要综述。
方法：由第一作者检索2000/2008 PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)有关骨髓间充质干细胞对移植免疫影响的文章，检索词为“BMSCs，hematopoietic stem cell transplantation，transplantantion immunity”，排除重复性研究。共保留37篇文献归纳总结。
结果与结论：骨髓间充质干细胞是存在于骨髓中除了造血干细胞外的另一种干细胞，在免疫反应中可以逃避免疫识别、抑制免疫反应。骨髓间充质干细胞的免疫抑制作用能有效地运用于造血干细胞移植，降低移植物抗宿主病、促进移植物存活等，有广阔的应用前景。但目前为止尚未能建立鉴定骨髓间充质干细胞的统一标准，至今还未能筛选到骨髓间充质干细胞特异性的标记分子；缺乏安全性评价；影响移植物抗宿主病同时是否影响移植物抗白血病效应；以及对肿瘤细胞生长的影响等问题都有待于进一步的研究才能解决。

关键词: 移植免疫, 骨髓间充质干细胞, 造血干细胞移植, 免疫抑制, 细胞鉴定

Abstract:

BACKGROUND: Recent studies have demonstrated that bone marrow mesenchymal stem cells (BMSCs) can support in vitro hematopoiesis, promote reconstruction of in vivo hematopoietic function, have low immunogenicity and inhibit proliferation of allogenic T lymphocytes, and play important roles in regulating transplantation immunity. However, its mechanism remains unclear.
OBJECTIVE: To summarize the immunoloregulation characteristics of BMSCs and its effects on hematopoietic stem cell transplantation.
METHODS: The first author searched PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) published from 2000 to 2008 for articles on effects of BMSCs on transplantation immunity. The key words were “BMSCs, hematopoietic stem cell transplantation, transplantation immunity”. Repetitive studies were excluded. Finally, 37 articles were included for this review.
RESULTS AND CONCLUSION: BMSCs are stem cells in the bone marrow besides hematopoietic stem cells. In immune reaction, BMSCs can avoid immunological recognition, and suppress immune reaction. The immunesuppressive effects of BMSCs are effectively used in hematopoietic stem cell transplantation, can decrease graft versus host disease, promote graft survival, and have wide application prospect. However, at present, there is no unified standard to identify BMSCs, and the specific marker of BMSCs has not been screened. Some problems should be further investigated such as lack of safety assessment, whether BMSCs affected graft versus leukemia when affected graft versus host disease, as well as the effects on tumor cell growth.

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