中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (48): 9007-9010.doi: 10.3969/j.issn.1673-8225.2010.48.019

• 骨与关节图像与影像 bone and joint imaging • 上一篇    下一篇

功能性磁共振成像与针刺研究的基线选择　

陈尚杰1，2，彭淑明3，许明辉2，张家维3，石学敏◇2   

  1. 1深圳市宝安人民医院康复科，广东省深圳市  518101；2天津中医药大学，天津市   300193；3广州中医药大学，广东省广州市 510006
  • 出版日期:2010-11-26 发布日期:2010-11-26
  • 作者简介:陈尚杰☆，男，1970年，江西省九江市人，汉族，2007年广州中医药大学毕业，博士，副主任医师，主要从事针灸的脑功能成像研究。 csjme@163.com
  • 基金资助:

    中国博士后基金(20090460700)；深圳市科技计划项目(200902159)。

Selection of the baseline in functional MRI study of acupuncture

Chen Shang-jie 1, 2, Peng Shu-ming3, Xu Ming-hui2, Zhang Jia-wei3, Shi Xue-min2   

  1. 1 Department of Rehabilitation, Baoan People’s Hospital of Shenzhen, Shenzhen  510170, Guangdong Province, China; 2 Tianjin University of Traditional Chinese Medicine, Tianjin  300193, China; 3 Guangzhou University of Traditional Chinese Medicine, Guangzhou  51006, Guangdong Province, China
  • Online:2010-11-26 Published:2010-11-26
  • About author:Chen Shang-jie☆, Doctor, Associate chief physician, Department of Rehabilitation, Baoan People’s Hospital of Shenzhen, Shenzhen 510170, Guangdong Province, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China csjme@163.com
  • Supported by:

     the National Science Foundation for Post-doctoral Scientists of China, No. 20090460700*; the Science and Technology Program of Shenzhen, No. 200902159*

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摘要：

背景：功能性磁共振成像是近年发展起来研究穴位特异性的重要武器。目前大多数的针刺的功能性磁共振成像研究仍采用组块设计，而且绝大多数的都是在入针之后进行功能像扫描，认为入针后的静息段为纯静息，做为基线对照。但这与传统的针灸理论相冲突，因为传统针灸认为入针后也会出现入针效应。
目的：探讨如何选择针刺的功能性磁共振成像研究的基线。 
方法：采用Hui的多组块设计，对入针后的效应进行相关分析，观察入针后是否有脑功能激活。
结果与结论：触觉刺激在刺激完成后，静息阶段不存在明显的脑功能变化；而针刺的入针时会产生一定的脑功能变化，入针后的静息段并非纯静息段。入针后的静息段也许不适于作基线。

关键词: 针刺, 功能磁共振成像, 基线, 脑, 组块设计

Abstract:

BACKGROUND: Functional MRI (fMRI) is important to study acupoint specificity in recent year. Most of fMRI studies of acupuncture utilize the block design, and scanned after the needle is inserted. It is supposed that resting after needle into acupoint is pure rest and can be a baseline control. However, it is conflict with traditional Chinese acupuncture theory which thinks that acupuncture effect occurs after the needle into acupoint.
OBJECTIVE: To investigate how to choose baseline of acupuncture fMRI.
METHODS: Block design in Hui’s method was used. Acupuncture effect after needling into acupoint was analyzed to observe whether there was activation of brain function after needling into acupoint.
RESULTS AND CONCLUSION: It did not produce a certain function after tactile stimulus. But it produced a certain function after needling into acupoint. Rest phase after needling is not pure rest phase and is not a good baseline.

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